Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660.
Article CAS PubMed Google Scholar
Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Zucman-Rossi J, Finn RS. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7(1):6. https://doi.org/10.1038/s41572-020-00240-3.
Rumgay H, Ferlay J, de Martel C, Georges D, Ibrahim AS, Zheng R, Wei W, Lemmens VEPP, Soerjomataram I. Global, regional and national burden of primary liver cancer by subtype. Eur J Cancer. 2022;161:108–18. https://doi.org/10.1016/j.ejca.2021.11.023.
Rashed WM, Kandeil MAM, Mahmoud MO, Ezzat S. Hepatocellular Carcinoma (HCC) in Egypt: a comprehensive overview. J Egypt Natl Canc Inst. 2020;32(1):5. https://doi.org/10.1186/s43046-020-0016-x.
Nordenstedt H, White DL, El-Serag HB. The changing pattern of epidemiology in hepatocellular carcinoma. Dig Liver Dis. 2010;42 Suppl 3(Suppl 3):S206–14. https://doi.org/10.1016/S1590-8658(10)60507-5.
Schinzari V, Barnaba V, Piconese S. Chronic hepatitis B virus and hepatitis C virus infections and cancer: synergy between viral and host factors. Clin Microbiol Infect. 2015;21(11):969–74. https://doi.org/10.1016/j.cmi.2015.06.026.
Article CAS PubMed Google Scholar
Aliyu M, Zohora FT, Anka AU, Ali K, Maleknia S, Saffarioun M, Azizi G. Interleukin-6 cytokine: an overview of the immune regulation, immune dysregulation, and therapeutic approach. Int Immunopharmacol. 2022;111: 109130. https://doi.org/10.1016/j.intimp.2022.109130.
Article CAS PubMed Google Scholar
El-senosy FM, Morsy MM, El-Tokhy HM, ElBagour I, Elhadad SM. Evaluation of serum level of IL-6 in chronic hepatitis C virus infected egyptian patients. Am J Med Sci Medicine. 2018;6(1):5–12. https://doi.org/10.12691/ajmsm-6-1-2.
Gao B. Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease. J Gastroenterol Hepatol. 2012;27 Suppl 2(Suppl 2):89–93. https://doi.org/10.1111/j.1440-1746.2011.07003.x.
Article CAS PubMed Google Scholar
Labenz C, Toenges G, Huber Y, Nagel M, Marquardt JU, Schattenberg JM, Galle PR, Labenz J, Wörns MA. Raised serum Interleukin-6 identifies patients with liver cirrhosis at high risk for overt hepatic encephalopathy. Aliment Pharmacol Ther. 2019;50(10):1112–9. https://doi.org/10.1111/apt.15515.
Article CAS PubMed Google Scholar
Adnan F, Khan NU, Iqbal A, Ali I, Petruzziello A, Sabatino R, Guzzo A, Loquercio G, Botti G, Khan S, Naeem M, Khan MI. Interleukin-6 polymorphisms in HCC patients chronically infected with HCV. Infect Agent Cancer. 2020;15:21. https://doi.org/10.1186/s13027-020-00285-9.
Article CAS PubMed PubMed Central Google Scholar
Elsaid A, Abdel-Aziz AF, Elmougy R, Elwaseef AM. Association of polymorphisms G(-174)C in IL-6 gene and G(-1082)A in IL-10 gene with traditional cardiovascular risk factors in patients with coronary artery disease. Indian J Biochem Biophys. 2014;51(4):282–92.
Giannitrapani L, Soresi M, Balasus D, Licata A, Montalto G. Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma. World J Gastroenterol. 2013;19(16):2449–55. https://doi.org/10.3748/wjg.v19.i16.2449.
Article CAS PubMed PubMed Central Google Scholar
Park BL, Lee HS, Kim YJ, Kim JY, Jung JH, Kim LH, Shin HD. Association between interleukin 6 promoter variants and chronic hepatitis B progression. Exp Mol Med. 2003;35(2):76–82. https://doi.org/10.1038/emm.2003.11.
Article CAS PubMed Google Scholar
Olomolaiye O, Wood NA, Bidwell JL. A novel NlaIII polymorphism in the human IL-6 promoter. Eur J Immunogenet. 1998;25(2–3):267.
Arroyo V, Ginès P, Gerbes AL, Dudley FJ, Gentilini P, Laffi G, Reynolds TB, Ring-Larsen H, Schölmerich J. Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis International Ascites Club. Hepatology. 1996;23(1):164–76. https://doi.org/10.1002/hep.510230122.
Article CAS PubMed Google Scholar
Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91. https://doi.org/10.3758/bf03193146.
Ntellas P, Chau I. Updates on systemic therapy for hepatocellular carcinoma. Am Soc Clin Oncol Educ Book. 2024;44:e430028. https://doi.org/10.1200/EDBK_430028. American Society of Clinical Oncology. Annual Meeting.
Dai CY, Tsai YS, Chou WW, Liu T, Huang CF, Wang SC, Tsai PC, Yeh ML, Hsieh MY, Huang CI, Vanson Liu SY, Huang JF, Chuang WL, Yu ML. The IL-6/STAT3 pathway upregulates microRNA-125b expression in hepatitis C virus infection. Oncotarget. 2018;9(13):11291–302. https://doi.org/10.18632/oncotarget.24129.
Article PubMed PubMed Central Google Scholar
Shao YY, Lin H, Li YS, Lee YH, Chen HM, Cheng AL, Hsu CH. High plasma interleukin-6 levels associated with poor prognosis of patients with advanced hepatocellular carcinoma. Jpn J Clin Oncol. 2017;47(10):949–53. https://doi.org/10.1093/jjco/hyx103.
Song J, Zhang X, Ge Q, Yuan C, Chu L, Liang HF, Liao Z, Liu Q, Zhang Z, Zhang B. CRISPR/Cas9-mediated knockout of HBsAg inhibits proliferation and tumorigenicity of HBV-positive hepatocellular carcinoma cells. J Cell Biochem. 2018;119(10):8419–31. https://doi.org/10.1002/jcb.27050.
Article CAS PubMed PubMed Central Google Scholar
Xu J, Lin H, Wu G, Zhu M, Li M. IL-6/STAT3 is a promising therapeutic target for hepatocellular carcinoma. Front Oncol. 2021;11:760971. https://doi.org/10.3389/fonc.2021.760971.
Article CAS PubMed PubMed Central Google Scholar
Baran P, Hansen S, Waetzig GH, Akbarzadeh M, Lamertz L, Huber HJ, Ahmadian MR, Moll JM, Scheller J. The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling. J Biol Chem. 2018;293(18):6762–75. https://doi.org/10.1074/jbc.RA117.001163.
Article CAS PubMed PubMed Central Google Scholar
Prenissl N, Lokau J, Rose-John S, Haybaeck J, Garbers C. Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage. Cytokine. 2019;114:1–5. https://doi.org/10.1016/j.cyto.2018.11.023.
Article CAS PubMed Google Scholar
Rose-John S. Interleukin-6 Family Cytokines. Cold Spring Harb Perspect Biol. 2018;10(2):a028415. https://doi.org/10.1101/cshperspect.a028415.
Article CAS PubMed PubMed Central Google Scholar
Sghaier I, Mouelhi L, Rabia NA, Alsaleh BR, Ghazoueni E, Almawi WY, Loueslati BY. Genetic variants in IL-6 and IL-10 genes and susceptibility to hepatocellular carcinoma in HCV infected patients. Cytokine. 2017;89:62–7. https://doi.org/10.1016/j.cyto.2016.10.004.
Article CAS PubMed Google Scholar
Dondeti MF, El-Maadawy EA, Talaat RM. Hepatitis-related hepatocellular carcinoma: insights into cytokine gene polymorphisms. World J Gastroenterol. 2016;22(30):6800–16. https://doi.org/10.3748/wjg.v22.i30.6800.
Article CAS PubMed PubMed Central Google Scholar
Wang X, Yan Z, Ye Q. Interleukin-6 gene polymorphisms and susceptibility to liver diseases: a meta-analysis. Medicine. 2019;98(50):e18408. https://doi.org/10.1097/MD.0000000000018408.
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