Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis

Aayadi H, Mittal SPK, Deshpande A, Gore M, Ghaskadbi SS. Protective effect of geraniin against carbon tetrachloride induced acute hepatotoxicity in Swiss albino mice. Biochem Biophys Res Commun. 2017;487(1):62–7.

Article  CAS  PubMed  Google Scholar 

Adams M, Ettl S, Kunert O, Wube AA, Haslinger E, Bucar F, et al. Antimycobacterial activity of geranylated furocoumarins from Tetradium daniellii. Planta Med. 2006;72(12):1132–5.

Article  CAS  PubMed  Google Scholar 

Ambrosetti D, Holmes G, Mansukhani A, Basilico C. Fibroblast growth factor signaling uses multiple mechanisms to inhibit Wnt-induced transcription in osteoblasts. Mol Cell Biol. 2008;28(15):4759–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ara H, Subedi U, Sharma P, Bhattarai S, Sharma S, Manikandan S, et al. Alteration of cellular energy metabolism through LPAR2-Axin2 axis in gastric cancer. Biomolecules. 2022;12(12):1805.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arioka M, Takahashi-Yanaga F, Sasaki M, Yoshihara T, Morimoto S, Hirata M, et al. Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis. Biochem Pharmacol. 2014;90(4):397–405.

Article  CAS  PubMed  Google Scholar 

Ashrafizadeh M, Ahmadi Z, Farkhondeh T, Samarghandian S. Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities. J Cell Physiol. 2020;235(5):4135–45.

Article  CAS  PubMed  Google Scholar 

Ashrafizadeh M, Rafiei H, Mohammadinejad R, Farkhondeh T, Samarghandian S. Wnt-regulating microRNAs role in gastric cancer malignancy. Life Sci. 2020;250:117547.

Article  CAS  PubMed  Google Scholar 

Aydin S, Kuloglu T, Aydin S, Kalayci M, Yilmaz M, Cakmak T, et al. A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues. Peptides. 2014;61:130–6.

Article  CAS  PubMed  Google Scholar 

Badimon L, Luquero A, Crespo J, Peña E, Borrell-Pages M. PCSK9 and LRP5 in macrophage lipid internalization and inflammation. Cardiovasc Res. 2021;117(9):2054–68.

Article  CAS  PubMed  Google Scholar 

Balemans W, Van Hul W. The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes. Endocrinology. 2007;148(6):2622–9.

Article  CAS  PubMed  Google Scholar 

Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science. 2007;316(5831):1619–22.

Article  CAS  PubMed  Google Scholar 

Boakye YD, Agyare C, Abotsi WK, Ayande PG, Ossei PP. Anti-inflammatory activity of aqueous leaf extract of Phyllanthus muellerianus (Kuntze) Exell. and its major constituent, geraniin. J Ethnopharmacol. 2016;187:17–27.

Article  CAS  PubMed  Google Scholar 

Borrell-Pagès M, Romero JC, Juan-Babot O, Badimon L. Wnt pathway activation, cell migration, and lipid uptake is regulated by low-density lipoprotein receptor-related protein 5 in human macrophages. Eur Heart J. 2011;32(22):2841–50.

Article  PubMed  Google Scholar 

Cai Z, Liu J, Bian H, Cai J. Albiflorin alleviates ovalbumin (OVA)-induced pulmonary inflammation in asthmatic mice. Am J Transl Res. 2019;11(12):7300–9.

CAS  PubMed  PubMed Central  Google Scholar 

Capurro V, Lanfranco M, Summa M, Porceddu PF, Ciampoli M, Margaroli N, et al. The mood stabilizing properties of AF3581, a novel potent GSK-3β inhibitor. Biomed Pharmacother. 2020;128:110249.

Article  CAS  PubMed  Google Scholar 

Carrino M, Quotti Tubi L, Fregnani A, Canovas Nunes S, Barilà G, Trentin L, et al. Prosurvival autophagy is regulated by protein kinase CK1 alpha in multiple myeloma. Cell Death Discov. 2019;5:98.

Article  PubMed  PubMed Central  Google Scholar 

Cederroth CR, Auger J, Zimmermann C, Eustache F, Nef S. Soy, phyto-oestrogens and male reproductive function: a review. Int J Androl. 2010;33(2):304–16.

Article  CAS  PubMed  Google Scholar 

Chen S, Yang L, He S, Yang J, Liu D, Bao Q, et al. Preactivation of β-catenin in osteoblasts improves the osteoanabolic effect of PTH in type 1 diabetic mice. J Cell Physiol. 2020;235(2):1480–93.

Article  CAS  PubMed  Google Scholar 

Chen Z, Zhang Y, Zhao F, Yin C, Yang C, Wang X, et al. Recombinant irisin prevents the reduction of osteoblast differentiation induced by stimulated microgravity through increasing β-catenin expression. Int J Mol Sci. 2020;21(4):1259.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng X, Wei B, Sun L, Hu X, Liang J, Chen Y. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway. Phytother Res. 2016;30(10):1680–8.

Article  CAS  PubMed  Google Scholar 

Cheng J, Shen W, Jin L, Pan J, Zhou Y, Pan G, et al. Treadmill exercise promotes neurogenesis and myelin repair via upregulating Wnt/β-catenin signaling pathways in the juvenile brain following focal cerebral ischemia/reperfusion. Int J Mol Med. 2020;45(5):1447–63.

CAS  PubMed  PubMed Central  Google Scholar 

Cheong JK, Virshup DM. Casein kinase 1: complexity in the family. Int J Biochem Cell Biol. 2011;43(4):465–9.

Article  CAS  PubMed  Google Scholar 

Chu Y, Gao Y, Yang Y, Liu Y, Guo N, Wang L, et al. β-catenin mediates fluoride-induced aberrant osteoblasts activity and osteogenesis. Environ Pollut. 2020;265(Pt A):114734.

Article  CAS  PubMed  Google Scholar 

Compston JE, McClung MR, Leslie WD. Osteoporosis. Lancet. 2019;393(10169):364–76.

Article  CAS  PubMed  Google Scholar 

Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature. 2001;412(6842):86–90.

Article  CAS  PubMed  Google Scholar 

Delany AM, Amling M, Priemel M, Howe C, Baron R, Canalis E. Osteopenia and decreased bone formation in osteonectin-deficient mice. J Clin Invest. 2000;105(7):915–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deldar Abad Paskeh M, Mirzaei S, Ashrafizadeh M, Zarrabi A, Sethi G. Wnt/β-catenin signaling as a driver of hepatocellular carcinoma progression: an emphasis on molecular pathways. J Hepatocell Carcinoma. 2021;8:1415–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Devalaraja S, Jain S, Yadav H. Exotic fruits as therapeutic complements for diabetes, obesity and metabolic syndrome. Food Res Int. 2011;44(7):1856–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding J, Lee SJ, Vlahos L, Yuki K, Rada CC, van Unen V, et al. Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD(4)-selective WNT surrogate in mice. Nat Commun. 2023;14(1):2947.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong B, Simonson L, Vold S, Oldham E, Barten L, Ahmad N, et al. FZD6 promotes melanoma cell invasion but not proliferation by regulating canonical wnt signaling and epithelial-mesenchymal transition. J Invest Dermatol. 2023;143(4):621-29.e6.

Article  CAS 

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