Bhujwalla Z, Kakkad S, Chen Z, Jin J, Hapuarachchige S, Artemov D, et al. Theranostics and metabolotheranostics for precision medicine in oncology. J Magn Reson (San Diego, Calif: 1997). 2018;291:141–51.
Hamperl S, Cimprich KA. The contribution of co-transcriptional RNA: DNA hybrid structures to DNA damage and genome instability. DNA Repair (Amst). 2014;19:84–94.
Article PubMed CAS Google Scholar
Sanz LA, Hartono SR, Lim YW, et al. Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals. Mol Cell. 2016;63(1):167–78.
Article PubMed PubMed Central CAS Google Scholar
Li M, Klungland A. Modifications and interactions at the R-loop. DNA Repair (Amst). 2020;96:102958.
Article PubMed CAS Google Scholar
Niehrs C, Luke B. Regulatory R-loops as facilitators of gene expression and genome stability. Nat Rev Mol Cell Biol. 2020;21(3):167–78.
Article PubMed PubMed Central CAS Google Scholar
Santos-Pereira JM, Aguilera A. R loops: new modulators of genome dynamics and function. Nat Rev Genet. 2015;16(10):583–97.
Article PubMed CAS Google Scholar
Yasuhara T, Kato R, Hagiwara Y, Shiotani B, Yamauchi M, Nakada S, et al. Human rad52 promotes XPG-mediated R-loop processing to initiate transcription-associated homologous recombination repair. Cell. 2018;175(2):558–70.
Article PubMed CAS Google Scholar
Sun Q, Csorba T, Skourti-Stathaki K, Proudfoot NJ, Dean C. R-loop stabilization represses antisense transcription at the arabidopsis FLC locus. Science. 2013;340(6132):619–21.
Article PubMed PubMed Central CAS Google Scholar
Richard P, Manley JL. R Loops and links to human disease. J Mol Biol. 2017;429(21):3168–80.
Article PubMed CAS Google Scholar
Tan SLW, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, et al. A class of environmental and endogenous toxins induces BRCA2 haploinsufficiency and genome instability. Cell. 2017;169(6):1105–18.
Article PubMed PubMed Central CAS Google Scholar
Chen L, Chen JY, Huang YJ, Gu Y, Qiu J, Qian H, et al. The augmented R-Loop is a unifying mechanism for myelodysplastic syndromes induced by high-risk splicing factor mutations. Mol Cell. 2018;69(3):412–25.
Article PubMed PubMed Central CAS Google Scholar
Brickner JR, Garzon JL, Cimprich KA. Walking a tightrope: The complex balancing act of R-loops in genome stability. Mol Cell. 2022;82(12):2267–97.
Article PubMed PubMed Central CAS Google Scholar
Abakir A, Giles TC, Cristini A, et al. N6-methyladenosine regulates the stability of RNA: DNA hybrids in human cells. Nat Genet. 2020;52(1):48–55.
Article PubMed CAS Google Scholar
Liu Z, Gao L, Cheng L, et al. The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications. Exp Mol Med. 2023;55(3):487–501.
Article PubMed PubMed Central CAS Google Scholar
Zaccara S, Ries RJ, Jaffrey SR. Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol. 2023;24(10):770.
Article PubMed CAS Google Scholar
Liu J, Ren D, Du Z, Wang H, Zhang H, Jin Y. mA demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression. Biochem Biophys Res Commun. 2018;502(4):456–64.
Article PubMed CAS Google Scholar
Wang Q, Chen C, Ding Q, et al. METTL3-mediated mA modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. Gut. 2020;69(7):1193–205.
Article PubMed CAS Google Scholar
Ma JZ, Yang F, Zhou CC, et al. METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6 -methyladenosine-dependent primary MicroRNA processing. Hepatology. 2017;65(2):529–43.
Article PubMed CAS Google Scholar
Niu Y, Lin Z, Wan A, et al. RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3. Mol Cancer. 2019;18(1):46. Published 2019 Mar 28.
Paris J, Morgan M, Campos J, et al. Targeting the RNA mA Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019;25(1):137-148.e6.
Article PubMed PubMed Central CAS Google Scholar
Liu J, Eckert MA, Harada BT, et al. m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018;20(9):1074–83.
Article PubMed PubMed Central CAS Google Scholar
Hao L, Wang JM, Liu BQ, et al. m6A-YTHDF1-mediated TRIM29 upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells. Biochim Biophys Acta Mol Cell Res. 2021;1868(1):118878.
Article PubMed CAS Google Scholar
Petermann E, Lan L, Zou L. Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids. Nat Rev Mol Cell Biol. 2022;23(6):444.
Article PubMed CAS Google Scholar
Thomas M, White RL, Davis RW. Hybridization of RNA to double-stranded DNA: formation of R-loops. Proc Natl Acad Sci U S A. 1976;73(7):2294–8.
Article PubMed PubMed Central CAS Google Scholar
García-Muse T, Aguilera A. R Loops: From Physiological to Pathological Roles. Cell. 2019;179(3):604–18.
Hegazy YA, Fernando CM, Tran EJ. The balancing act of R-loop biology: The good, the bad, and the ugly. J Biol Chem. 2020;295(4):905–13.
Lang KS, Hall AN, Merrikh CN, et al. Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis. Cell. 2017;170(4):787-799.e18.
Article PubMed PubMed Central CAS Google Scholar
Stork CT, Bocek M, Crossley MP, et al. Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. Elife. 2016;5:e17548.
Article PubMed PubMed Central Google Scholar
Tresini M, Warmerdam DO, Kolovos P, et al. The core spliceosome as target and effector of non-canonical ATM signalling. Nature. 2015;523(7558):53–8.
Article PubMed PubMed Central CAS Google Scholar
Wellinger RE, Prado F, Aguilera A. Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex. Mol Cell Biol. 2006;26(8):3327–34.
Article PubMed PubMed Central CAS Google Scholar
Tan-Wong SM, Dhir S, Proudfoot NJ. R-Loops Promote Antisense Transcription across the Mammalian Genome. Mol Cell. 2019;76(4):600-616.e6.
留言 (0)