Epigenomic heterogeneity as a source of tumour evolution

Ciriello, G. et al. Cancer evolution: a multifaceted affair. Cancer Discov. 14, 36–48 (2024).

Article  CAS  PubMed  Google Scholar 

Marine, J.-C., Dawson, S.-J. & Dawson, M. A. Non-genetic mechanisms of therapeutic resistance in cancer. Nat. Rev. Cancer 20, 743–756 (2020).

Article  CAS  PubMed  Google Scholar 

Hanahan, D. Hallmarks of cancer: new dimensions. Cancer Discov. 12, 31–46 (2022).

Article  CAS  PubMed  Google Scholar 

Rahme, G. J. et al. Modeling epigenetic lesions that cause gliomas. Cell 186, 3674–3685.e14 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaudet, F. et al. Induction of tumors in mice by genomic hypomethylation. Science 300, 489–492 (2003).

Article  CAS  PubMed  Google Scholar 

Parreno, V. et al. Transient loss of Polycomb components induces an epigenetic cancer fate. Nature 629, 688–696 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cimmino, L. et al. Restoration of TET2 function blocks aberrant self-renewal and leukemia progression. Cell 170, 1079–1095.e20 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mack, S. C. et al. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature 506, 445–450 (2014). This report describes a primary tumour arising and dependent solely on chromatin variants (as opposed to mutations).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bertucci, F. et al. Genomic characterization of metastatic breast cancers. Nature 569, 560–564 (2019).

Article  CAS  PubMed  Google Scholar 

Burdett, N. L. et al. Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer. Nat. Genet. 55, 437–450 (2023). This paper demonstrates the mixed genetic and non-genetic evolution of metastatic ovarian cancer.

Article  CAS  PubMed  Google Scholar 

Makohon-Moore, A. P. et al. Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer. Nat. Genet. 49, 358–366 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

McDonald, O. G. et al. Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. Nat. Genet. 49, 367–376 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Preissl, S., Gaulton, K. J. & Ren, B. Characterizing cis-regulatory elements using single-cell epigenomics. Nat. Rev. Genet 24, 21–43 (2023).

Article  CAS  PubMed  Google Scholar 

Casado-Pelaez, M., Bueno-Costa, A. & Esteller, M. Single cell cancer epigenetics. Trends Cancer 8, 820–838 (2022).

Article  CAS  PubMed  Google Scholar 

Nam, A. S., Chaligne, R. & Landau, D. A. Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics. Nat. Rev. Genet. 22, 3–18 (2021).

Article  CAS  PubMed  Google Scholar 

Becker, W. R. et al. Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer. Nat. Genet. 54, 985–995 (2022). This multi-regional sampling study shows that a continuum of epigenomic-state transitions exist during tumorigenesis.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh, H. et al. Hybrid stomach-intestinal chromatin states underlie human Barrett’s metaplasia. Gastroenterology 161, 924–939.e11 (2021).

Article  CAS  PubMed  Google Scholar 

Burdziak, C. et al. Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis. Science 380, eadd5327 (2023). This report shows that heterogeneous cell states are primed for transformation through crosstalk with immune cells and chromatin remodelling.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, L. et al. The phenotypes of proliferating glioblastoma cells reside on a single axis of variation. Cancer Discov. 9, 1708–1719 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guilhamon, P. et al. Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival. eLife 10, e64090 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, L. et al. A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets. Nat. Cancer 3, 1534–1552 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Regner, M. J. et al. A multi-omic single-cell landscape of human gynecologic malignancies. Mol. Cell 81, 4924–4941.e10 (2021).

Article  CAS  PubMed  Google Scholar 

Terekhanova, N. V. et al. Epigenetic regulation during cancer transitions across 11 tumour types. Nature 623, 432–441 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harpaz, N. et al. Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas. Mol. Cell 82, 2696–2713.e9 (2022).

Article  CAS  PubMed  Google Scholar 

Pixberg, C. F. et al. Analysis of DNA methylation in single circulating tumor cells. Oncogene 36, 3223–3231 (2017).

Article  CAS  PubMed  Google Scholar 

Gkountela, S. et al. Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding. Cell 176, 98–112.e14 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, H. et al. Single-cell DNA methylome analysis of circulating tumor cells. Chin. J. Cancer Res. 33, 391–404 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Cheow, L. F. et al. Single-cell multimodal profiling reveals cellular epigenetic heterogeneity. Nat. Methods 13, 833–836 (2016).

Article  CAS  PubMed  Google Scholar 

Chaligne, R. et al. Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states. Nat. Genet. 53, 1469–1479 (2021). This study showcases the use of single-cell multiomics to relate epigenomic changes to cell-state evolution.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson, K. C. et al. Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response. Nat. Genet. 53, 1456–1468 (2021). This study quantifies a DNA methylation disorder and its relationship to tumour evolution in glioma.

Article  CAS  PubMed  PubMed Central 

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