Oyelaran, O. & Gildersleeve, J. C. Glycan arrays: recent advances and future challenges. Curr. Opin. Chem. Biol. 13, 406–413 (2009).
Article CAS PubMed PubMed Central Google Scholar
Cobb, B. A. & Kasper, D. L. Coming of age: carbohydrates and immunity. Eur. J. Immunol. 35, 352–356 (2005).
Article CAS PubMed Google Scholar
Smith, B. A. H. & Bertozzi, C. R. The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans. Nat. Rev. Drug Discov. 20, 217–243 (2021).
Article CAS PubMed PubMed Central Google Scholar
Blixt, O. et al. Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Proc. Natl Acad. Sci. USA 101, 17033–17038 (2004).
Article CAS PubMed PubMed Central Google Scholar
Razi, N. & Varki, A. Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes. Proc. Natl Acad. Sci. USA 95, 7469–7474 (1998).
Article CAS PubMed PubMed Central Google Scholar
Collins, B. E. et al. Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact. Proc. Natl Acad. Sci. USA 101, 6104–6109 (2004).
Article CAS PubMed PubMed Central Google Scholar
Kiessling, L. L. & Grim, J. C. Glycopolymer probes of signal transduction. Chem. Soc. Rev. 42, 4476–4491 (2013).
Article CAS PubMed Google Scholar
Frenz, T. et al. Antigen presenting cell-selective drug delivery by glycan-decorated nanocarriers. Eur. J. Pharm. Biopharm. 95, 13–17 (2015).
Article CAS PubMed Google Scholar
Alam, M. M. et al. Glycan-modified virus-like particles evoke T helper type 1-like immune responses. Acs Nano 15, 309–321 (2021).
Article CAS PubMed Google Scholar
Sojitra, M. et al. Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage. Nat. Chem. Biol. 17, 806–816 (2021).
Article CAS PubMed PubMed Central Google Scholar
Tjhung, K. F. et al. Silent encoding of chemical post-translational modifications in phage-displayed libraries. J. Am. Chem. Soc. 138, 32–35 (2016).
Article CAS PubMed Google Scholar
Lin, C.-L. et al. Chemoenzymatic synthesis of genetically-encoded multivalent liquid N-glycan arrays. Nat. Commun. 14, 5237 (2023).
Article CAS PubMed PubMed Central Google Scholar
Thomas, B. et al. Application of biocatalysis to on-DNA carbohydrate library synthesis. ChemBioChem 18, 858–863 (2017).
Article CAS PubMed Google Scholar
Yan, M. et al. Next-generation glycan microarray enabled by DNA-coded glycan library and next-generation sequencing technology. Anal. Chem. 91, 9221–9228 (2019).
Article CAS PubMed Google Scholar
Kondengaden, S. M. et al. DNA encoded glycan libraries as a next-generation tool for the study of glycan–protein interactions. Preprint at bioRxiv https://doi.org/10.1101/2020.03.30.017012 (2020).
Schmidt, E. N. et al. Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket. Nat. Commun. 14, 2327 (2023).
Article CAS PubMed PubMed Central Google Scholar
Crocker, P. R., Paulson, J. C. & Varki, A. Siglecs and their roles in the immune system. Nat. Rev. Immunol. 7, 255–266 (2007).
Article CAS PubMed Google Scholar
Nicoll, G. et al. Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via Siglec-7-dependent and -independent mechanisms. Eur. J. Immunol. 33, 1642–1648 (2003).
Article CAS PubMed Google Scholar
Jandus, C. et al. Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance. J. Clin. Invest. 124, 1810–1820 (2014).
Article CAS PubMed PubMed Central Google Scholar
Shenoy, G. N. et al. Sialic acid-dependent inhibition of T cells by exosomal ganglioside GD3 in ovarian tumor microenvironments. J. Immunol. 201, 3750–3758 (2018).
Article CAS PubMed Google Scholar
Laubli, H., Nalle, S. C. & Maslyar, D. Targeting the Siglec–sialic acid immune axis in cancer: current and future approaches. Cancer Immunol. Res. 10, 1423–1432 (2022).
Article CAS PubMed PubMed Central Google Scholar
Gray, M. A. et al. Targeted glycan degradation potentiates the anticancer immune response in vivo. Nat. Chem. Biol. 16, 1376–1384 (2020).
Article PubMed PubMed Central Google Scholar
Gonzalez-Gil, A., Li, T. A., Kim, J. & Schnaar, R. L. Human sialoglycan ligands for immune inhibitory Siglecs. Mol. Asp. Med. 90, 101110 (2023).
Jung, J. et al. Carbohydrate sulfation as a mechanism for fine-tuning Siglec ligands. ACS Chem. Biol. 16, 2673–2689 (2021).
Article CAS PubMed Google Scholar
Feinberg, H., Castelli, R., Drickamer, K., Seeberger, P. H. & Weis, W. I. Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins. J. Biol. Chem. 282, 4202–4209 (2007).
Article CAS PubMed Google Scholar
Matochko, W. L., Cory Li, S., Tang, S. K. Y. & Derda, R. Prospective identification of parasitic sequences in phage display screens. Nucleic Acids Res. 42, 1784–1798 (2014).
Article CAS PubMed Google Scholar
Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139–140 (2010).
Article CAS PubMed Google Scholar
Chen, Y., Lun, A. & Smyth, G. From reads to genes to pathways: differential expression analysis of RNA-seq experiments using Rsubread and the edgeR quasi-likelihood pipeline. F1000Research 5, 1438 (2016).
PubMed PubMed Central Google Scholar
Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate—a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57, 289–300 (1995).
Robinson, M. D. & Oshlack, A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 11, R25 (2010).
Article PubMed PubMed Central Google Scholar
Rodrigues, E. et al. A versatile soluble Siglec scaffold for sensitive and quantitative detection of glycan ligands. Nat. Commun. 11, 5091 (2020).
Article CAS PubMed PubMed Central Google Scholar
McCord, K. A. et al. Dissecting the ability of Siglecs to antagonize Fcγ receptors. ACS Cent. Sci. 10, 315–330 (2024).
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