Locati M, Curtale G, Mantovani A. Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol. 2020;15:123–47.
Article PubMed CAS Google Scholar
Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496:445–55.
Article PubMed PubMed Central CAS Google Scholar
Mantovani A, Garlanda C. Humoral innate immunity and acute-phase proteins. N. Engl J Med. 2023;388:439–52.
Article PubMed PubMed Central CAS Google Scholar
Park MD, Silvin A, Ginhoux F, Merad M. Macrophages in health and disease. Cell. 2022;185:4259–79.
Article PubMed PubMed Central CAS Google Scholar
Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357:539–45.
Article PubMed CAS Google Scholar
Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454:436–44.
Article PubMed CAS Google Scholar
Greten FR, Grivennikov SI. Inflammation and cancer: triggers, mechanisms, and consequences. Immunity. 2019;51:27–41.
Article PubMed PubMed Central CAS Google Scholar
Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, et al. IL-1beta(+) macrophages fuel pathogenic inflammation in pancreatic cancer. Nature. 2023;623:415–22.
Article PubMed CAS Google Scholar
Fridman WH. The tumor microenvironment: prognostic and theranostic impact. Recent advances and trends. Semin Immunol. 2020;48:101416.
Kloosterman DJ, Akkari L. Macrophages at the interface of the coevolving cancer ecosystem. Cell. 2023;186:1627–51.
Article PubMed CAS Google Scholar
Mantovani A, Marchesi F, Jaillon S, Garlanda C, Allavena P. Tumor-associated myeloid cells: diversity and therapeutic targeting. Cell Mol Immunol. 2021;18:566–78.
Article PubMed PubMed Central CAS Google Scholar
Mantovani A, Allavena P, Marchesi F, Garlanda C. Macrophages as tools and targets in cancer therapy. Nat Rev Drug Discov. 2022;21:799–820.
Article PubMed PubMed Central CAS Google Scholar
Joyce JA, Fearon DT. T-cell exclusion, immune privilege, and the tumor microenvironment. Science. 2015;348:74–80.
Article PubMed CAS Google Scholar
Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science. 2013;339:286–91.
Article PubMed PubMed Central CAS Google Scholar
De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell. 2013;23:277–86.
Pittet MJ, Michielin O, Migliorini D. Clinical relevance of tumor-associated macrophages. Nat Rev Clin Oncol. 2022;19:402–21.
Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 2004;21:137–48.
Article PubMed CAS Google Scholar
Kruse B, Buzzai AC, Shridhar N, Braun AD, Gellert S, Knauth K, et al. CD4(+) T-cell-induced inflammatory cell death controls immune-evasive tumors. Nature. 2023;618:1033–40.
Article PubMed PubMed Central CAS Google Scholar
Morad G, Helmink BA, Sharma P, Wargo JA. Hallmarks of response, resistance, and toxicity to immune checkpoint blockade. Cell. 2022;185:576.
Article PubMed CAS Google Scholar
Donadon M, Torzilli G, Cortese N, Soldani C, Di Tommaso L, Franceschini B, et al. Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis. J Exp Med. 2020;217:e20191847.
Article PubMed PubMed Central CAS Google Scholar
Cortese N, Carriero R, Barbagallo M, Putignano AR, Costa G, Giavazzi F, et al. High-resolution analysis of mononuclear phagocytes reveals GPNMB as a prognostic marker in human colorectal liver metastasis. Cancer Immunol Res. 2023;11:405–20.
Article PubMed PubMed Central CAS Google Scholar
Movahedi K, Laoui D, Gysemans C, Baeten M, Stange G, Van den Bossche J, et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 2010;70:5728–39.
Article PubMed CAS Google Scholar
Lavin Y, Kobayashi S, Leader A, Amir ED, Elefant N, Bigenwald C, et al. Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses. Cell. 2017;169:750–65 e17.
Article PubMed PubMed Central CAS Google Scholar
Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nat Med. 2018;24:1277–89.
Article PubMed CAS Google Scholar
Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, et al. Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species. Immunity. 2019;50:1317–34 e10.
Article PubMed PubMed Central CAS Google Scholar
Klemm F, Maas RR, Bowman RL, Kornete M, Soukup K, Nassiri S, et al. Interrogation of the microenvironmental landscape in brain tumors reveals disease-specific alterations of immune cells. Cell. 2020;181:1643–60 e17.
Article PubMed PubMed Central CAS Google Scholar
Friebel E, Kapolou K, Unger S, Nunez NG, Utz S, Rushing EJ, et al. Single-cell mapping of human brain cancer reveals tumor-specific instruction of tissue-invading leukocytes. Cell. 2020;181:1626–42 e20.
Article PubMed CAS Google Scholar
Azizi E, Carr AJ, Plitas G, Cornish AE, Konopacki C, Prabhakaran S, et al. Single-cell map of diverse immune phenotypes in the breast tumor microenvironment. Cell. 2018;174:1293–308 e36.
Article PubMed PubMed Central CAS Google Scholar
Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, et al. Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer. Cell. 2017;171:1611–24 e24.
Article PubMed PubMed Central CAS Google Scholar
Tirosh I, Izar B, Prakadan SM, Wadsworth MH 2nd, Treacy D, et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science. 2016;352:189–96.
留言 (0)