Croia, C., R. Bursi, D. Sutera, F. Petrelli, A. Alunno, and I. Puxeddu. 2019. One year in review 2019: Pathogenesis of rheumatoid arthritis. Clinical and Experimental Rheumatology 37:347–357.

PubMed  Google Scholar 

Smolen, J.S., J.C. Avila, and D. Aletaha. 2012. Tocilizumab inhibits progression of joint damage in rheumatoid arthritis irrespective of its anti-inflammatory effects: Disassociation of the link between inflammation and destruction. Annals of the Rheumatic Diseases 71:687–693.

Article  PubMed  CAS  Google Scholar 

Aletaha, D., and J.S. Smolen. 2018. Diagnosis and management of rheumatoid arthritis: A review. JAMA 320:1360–1372.

Article  PubMed  Google Scholar 

Tieri, P., X. Zhou, L. Zhu, and C. Nardini. 2014. Multi-omic landscape of rheumatoid arthritis: Re-evaluation of drug adverse effects. Frontiers in Cell and Developmental Biology 2:59.

Article  PubMed  PubMed Central  Google Scholar 

Yang, C., R.D. Williams, J.N. Swerdel, J.R. Almeida, E.S. Brouwer, E. Burn, L. Carmona, K. Chatzidionysiou, T. Duarte-Salles, W. Fakhouri, et al. 2022. Development and external validation of prediction models for adverse health outcomes in rheumatoid arthritis: A multinational real-world cohort analysis. Seminars in Arthritis and Rheumatism 56:152050.

Article  PubMed  CAS  Google Scholar 

Alamanos, Y., P.V. Voulgari, and A.A. Drosos. 2006. Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: A systematic review. Seminars in Arthritis and Rheumatism 36:182–188.

Article  PubMed  Google Scholar 

Okada, Y., D. Wu, G. Trynka, T. Raj, C. Terao, K. Ikari, Y. Kochi, K. Ohmura, A. Suzuki, S. Yoshida, et al. 2014. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506:376–381.

Article  PubMed  CAS  Google Scholar 

Wu, R., L. Long, Q. Zhou, J. Su, W. Su, and J. Zhu. 2021. Identification of hub genes in rheumatoid arthritis through an integrated bioinformatics approach. Journal of Orthopaedic Surgery and Research 16:458.

Article  PubMed  PubMed Central  Google Scholar 

Iwanaga, T., M. Shikichi, H. Kitamura, H. Yanase, and K. Nozawa-Inoue. 2000. Morphology and functional roles of synoviocytes in the joint. Archives of Histology and Cytology 63:17–31.

Article  PubMed  CAS  Google Scholar 

Berumen-Nafarrate, E., I. Leal-Berumen, E. Luevano, F.J. Solis, and E. Munoz-Esteves. 2002. Synovial tissue and synovial fluid. The Journal of Knee Surgery 15:46–48.

PubMed  Google Scholar 

Neumann, E., S. Lefevre, B. Zimmermann, S. Gay, and U. Muller-Ladner. 2010. Rheumatoid arthritis progression mediated by activated synovial fibroblasts. Trends in Molecular Medicine 16:458–468.

Article  PubMed  CAS  Google Scholar 

de Hair, M.J., L.C. Harty, D.M. Gerlag, C. Pitzalis, D.J. Veale, and P.P. Tak. 2011. Synovial tissue analysis for the discovery of diagnostic and prognostic biomarkers in patients with early arthritis. Journal of Rheumatology 38:2068–2072.

Article  PubMed  Google Scholar 

Altobelli, E., P.M. Angeletti, D. Piccolo, and R. De Angelis. 2017. Synovial fluid and serum concentrations of inflammatory markers in rheumatoid arthritis, psoriatic arthritis and osteoarthitis: A systematic review. Current Rheumatology Reviews 13:170–179.

Article  PubMed  CAS  Google Scholar 

Bustamante, M.F., R. Garcia-Carbonell, K.D. Whisenant, and M. Guma. 2017. Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis. Arthritis Research & Therapy 19:110.

Article  Google Scholar 

Yoshitomi, H. 2019. Regulation of immune responses and chronic inflammation by fibroblast-like synoviocytes. Frontiers in Immunology 10:1395.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Loh, C., S.H. Park, A. Lee, R. Yuan, L.B. Ivashkiv, and G.D. Kalliolias. 2019. TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis. Annals of the Rheumatic Diseases 78 (9): 1205–1214.

Article  PubMed  CAS  Google Scholar 

Gangishetti, U., S. Ramirez-Perez, K. Jones, A. Arif, H. Drissi, and P. Bhattaram. 2020. Chronic exposure to TNF reprograms cell signaling pathways in fibroblast-like synoviocytes by establishing long-term inflammatory memory. Science and Reports 10 (1): 20297.

Article  CAS  Google Scholar 

Konisti, S., S. Kiriakidis, and E.M. Paleolog. 2012. Hypoxia–a key regulator of angiogenesis and inflammation in rheumatoid arthritis. Nature Reviews Rheumatology 8:153–162.

Article  PubMed  CAS  Google Scholar 

Bartok, B., and G.S. Firestein. 2010. Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis. Immunological Reviews 233:233–255.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Quinonez-Flores, C.M., S.A. Gonzalez-Chavez, and C. Pacheco-Tena. 2016. Hypoxia and its implications in rheumatoid arthritis. Journal of Biomedical Science 23:62.

Article  PubMed  PubMed Central  Google Scholar 

Treissman, J., V. Yuan, J. Baltayeva, H.T. Le, B. Castellana, W.P. Robinson, and A.G. Beristain. 2020. Low oxygen enhances trophoblast column growth by potentiating differentiation of the extravillous lineage and promoting LOX activity. Development 147 (2): dev181263.

Article  PubMed  CAS  Google Scholar 

Jeon, C.H., J.K. Ahn, J.Y. Chai, H.J. Kim, E.K. Bae, S.H. Park, E.Y. Cho, H.S. Cha, K.S. Ahn, and E.M. Koh. 2008. Hypoxia appears at pre-arthritic stage and shows co-localization with early synovial inflammation in collagen induced arthritis. Clinical and Experimental Rheumatology 26:646–648.

PubMed  CAS  Google Scholar 

Dobin, A., C.A. Davis, F. Schlesinger, J. Drenkow, C. Zaleski, S. Jha, P. Batut, M. Chaisson, and T.R. Gingeras. 2013. STAR: Ultrafast universal RNA-seq aligner. Bioinformatics 29:15–21.

Article  PubMed  CAS  Google Scholar 

Liao, Y., G.K. Smyth, and W. Shi. 2014. featureCounts: An efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30:923–930.

Article  PubMed  CAS  Google Scholar 

Langfelder, P., and S. Horvath. 2008. WGCNA: an R package for weighted correlation network analysis. Bmc Bioinformatics 9:1–13.

Article  Google Scholar 

Cheng, L., Y. Hu, J. Sun, M. Zhou, and Q.H. Jiang. 2018. DincRNA: A comprehensive web-based bioinformatics toolkit for exploring disease associations and ncRNA function. Bioinformatics 34:1953–1956.

Article  PubMed  CAS  Google Scholar 

Yu, G.C., L.G. Wang, Y.Y. Han, and Q.Y. He. 2012. clusterProfiler: An R Package for Comparing Biological Themes Among Gene Clusters. Omics-A Journal of Integrative Biology 16:284–287.

Article  PubMed  PubMed Central  CAS  Google Scholar 

von Mering, C., M. Huynen, D. Jaeggi, S. Schmidt, P. Bork, and B. Snel. 2003. STRING: A database of predicted functional associations between proteins. Nucleic Acids Research 31:258–261.

Article  Google Scholar 

Shannon, P., A. Markiel, O. Ozier, N.S. Baliga, J.T. Wang, D. Ramage, N. Amin, B. Schwikowski, and T. Ideker. 2003. Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research 13:2498–2504.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Arnett, F.C., S.M. Edworthy, D.A. Bloch, D.J. McShane, J.F. Fries, N.S. Cooper, L.A. Healey, S.R. Kaplan, M.H. Liang, H.S. Luthra, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis and Rheumatism 31:315–324.

Article  PubMed  CAS  Google Scholar 

Konishi, H., S.E. Kanou, R. Yukimatsu, M. Inui, M. Sato, N. Yamamoto, M. Nakano, and M. Koshiba. 2022. Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A receptor signaling. Scientific Reports 12:6033.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shen, Y., L. Teng, Y.H. Qu, J. Liu, X.D. Zhu, S. Chen, L.F. Yang, Y.H. Huang, Q. Song, and Q. Fu. 2022. Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK sig