The authors acknowledge funding from the European Union Horizon 2020 research and innovation program ‘GLIORESOLVE’ (grant agreement no. 101073386). Funding is further acknowledged from Science Foundation Ireland (grants 18/RI/5759, 20/FFP-P/8884 and 20/FFP-P/8613), the Irish Health Research Board (grants ILP-POR-2019-066 and ILP-POR-2022-007), the Irish Higher Education Authority North South Research Program ‘RADCOL’ and the Luxembourg National Research Fund (C20/BM/14646004/GLASSLUX). Additional financial support is acknowledged from the Beaumont Hospital, Dublin Foundation, Brain Tumour Ireland and a private research funding donation (to A.T.B.).