Punicalagin as a novel selective aryl hydrocarbon receptor (AhR) modulator upregulates AhR expression through the PDK1/p90RSK/AP-1 pathway to promote the anti-inflammatory response and bactericidal activity of macrophages

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395:200–11.

Article  PubMed  PubMed Central  Google Scholar 

Steinhagen F, Schmidt SV, Schewe JC, Peukert K, Klinman DM, Bode C. Immunotherapy in sepsis - brake or accelerate? Pharmacol Ther. 2020;208:107476.

Article  CAS  PubMed  Google Scholar 

Stockinger B. Shah KA-O, Wincent E: AHR in the intestinal microenvironment: safeguarding barrier function. Nat Rev Gastroenterol Hepatol. 2021;18(8):559–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sládeková L, Mani S, Dvořák Z. Ligands and agonists of the aryl hydrocarbon receptor AhR: Facts and myths. Biochem Pharmacol. 2023;213:115626.

Article  PubMed  Google Scholar 

Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, et al. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature. 2014;511:184–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moura-Alves PA-O, Puyskens AA-O, Stinn AA-O, Klemm M, Guhlich-Bornhof UA-O, Dorhoi A, Furkert J, Kreuchwig A, Protze JA-O, Lozza LA-O, et al. Host monitoring of quorum sensing during Pseudomonas aeruginosa infection. Science. 2019;366:eaaw1629.

Article  CAS  PubMed  Google Scholar 

Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, et al. AhR sensing of bacterial pigments regulates antibacterial defence. Nature. 2014;512:387–92.

Article  CAS  PubMed  Google Scholar 

Shi JA-O, Du TA-O, Wang JA-O, Tang CA-O, Lei M, Yu W, Yang Y, Ma Y, Huang P, Chen H, et al. Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target. Sci Adv. 2023;9:eadf0211.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu J, Luo L, Tian L, Yin S, Ma X, Cheng S, Tang W, Yu J, Ma W, Zhou X, et al. Aryl hydrocarbon receptor promotes IL-10 expression in inflammatory macrophages through Src-STAT3 signaling pathway. Front Immunol. 2018;9:2033.

Article  PubMed  PubMed Central  Google Scholar 

Larigot L, Juricek L, Dairou J, Coumoul X. AhR signaling pathways and regulatory functions. Biochim Open. 2018;7:1–9.

Article  PubMed  PubMed Central  Google Scholar 

Bock KW. Aryl hydrocarbon receptor (AHR)-mediated inflammation and resolution: non-genomic and genomic signaling. Biochem Pharmacol. 2020;182:114220.

Article  CAS  PubMed  Google Scholar 

Safe S, Jin UA-O, Park H, Chapkin RA-O, Jayaraman A. Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs). Int J Mol Sci. 2020;21:6654.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dolciami D, Ballarotto M, Gargaro M, López-Cara LC, Fallarino F, Macchiarulo A. Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs). Eur J Med Chem. 2020;185:111842.

Article  CAS  PubMed  Google Scholar 

Venusova E, Kolesarova A. Horky PA-OX, Slama PA-OX: physiological and immune functions of punicalagin. Nutrients. 2021;13:2150.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pirzadeh M, Caporaso N, Rauf A, Shariati MA, Yessimbekov Z, Khan MU, Imran M, Mubarak MS. Pomegranate as a source of bioactive constituents: a review on their characterization, properties and applications. Crit Rev Food Sci Nutr. 2020;61:982–99.

Article  PubMed  Google Scholar 

Xu X, Yin P, Wan C, Chong X, Liu M, Cheng P, Chen J, Liu F, Xu J. Punicalagin inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4-mediated MAPKs and NF-κB activation. Inflammation. 2014;37:956–65.

Article  CAS  PubMed  Google Scholar 

Xu J, Cao K, Liu X, Zhao L, Feng ZA-O, Liu J. Punicalagin regulates signaling pathways in inflammation-associated chronic diseases. Antioxidants (Basel). 2021;11:29.

Article  PubMed  Google Scholar 

Romeo Y, Zhang X, Roux PP. Regulation and function of the RSK family of protein kinases. Biochem J. 2012;441:553–69.

Article  CAS  PubMed  Google Scholar 

Vázquez-Gómez G, Rocha-Zavaleta L, Rodríguez-Sosa M, Petrosyan P, Rubio-Lightbourn J. Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells. Toxicol Lett. 2018;289:54–62.

Article  PubMed  Google Scholar 

Di Meglio P, Duarte JH, Ahlfors H, Owens ND, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, et al. Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions. Immunity. 2014;40:989–1001.

Article  PubMed  PubMed Central  Google Scholar 

Morales-Bárcenas R, Sánchez-Pérez Y, Santibáñez-Andrade M, Chirino YI, Soto-Reyes E, García-Cuellar CM. Airborne particulate matter (PM(10)) induces cell invasion through Aryl Hydrocarbon Receptor and Activator Protein 1 (AP-1) pathway deregulation in A549 lung epithelial cells. Mol Biol Rep. 2023;50:107–19.

Article  PubMed  Google Scholar 

Ito S, Osaka M, Edamatsu T, Itoh Y, Yoshida M. Crucial Role of the Aryl Hydrocarbon Receptor (AhR) in Indoxyl Sulfate-Induced Vascular Inflammation. J Atheroscler Thromb. 2016;23:960–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang Y, Xiao H, Sun L, Zhang Y, Liu S, Luo B. LMP2A suppresses the role of AHR pathway through ERK signal pathway in EBV-associated gastric cancer. Virus Res. 2021;297:198399.

Article  CAS  PubMed  Google Scholar 

Mohammadi-Bardbori A, Bengtsson J, Rannug U, Rannug A, Wincent E. Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR). Chem Res Toxicol. 2012;25:1878–84.

Article  CAS  PubMed  Google Scholar 

Kimura A, Naka T, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T. Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J Exp Med. 2009;206:2027–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmidt JR, Haupt J, Riemschneider S, Kämpf C, Löffler D, Blumert C, Reiche K, Koehl U, Kalkhof S, Lehmann J. Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages. Front Immunol. 2023;14:1156493.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vogel CF, Khan EM, Leung PS, Gershwin ME, Chang WW, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB. J Biol Chem. 2014;289:1866–75.

Article  CAS  PubMed  Google Scholar 

Schmidt JV, Carver LA, Bradfield CA. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem. 1993;268:22203–9.

Article  CAS  PubMed  Google Scholar 

Schleussner N, Merkel O, Costanza MA-O, Liang HC, Hummel F, Romagnani C, Durek P, Anagnostopoulos I, Hummel M, Jöhrens K, et al. The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma. Leukemia. 2018;32:994–2007.

Article  Google Scholar 

Castro-Mondragon JA-OX, Riudavets-Puig RA-O, Rauluseviciute IA-O, Lemma RA-O, Turchi LA-O, Blanc-Mathieu RA-O, Lucas JA-O, Boddie P, Khan AA-O, Manosalva Pérez NA-O, et al. JASPAR 2022: the 9th

留言 (0)

沒有登入
gif