Corfield, A. P. Mucins: a biologically relevant glycan barrier in mucosal protection. Biochim. Biophys. Acta 1850, 236–252 (2015).
Article CAS PubMed Google Scholar
Linden, S. K., Sutton, P., Karlsson, N. G., Korolik, V. & McGuckin, M. A. Mucins in the mucosal barrier to infection. Mucosal Immunol. 1, 183–197 (2008).
Article CAS PubMed PubMed Central Google Scholar
Hansson, G. C. Mucins and the microbiome. Annu. Rev. Biochem. 89, 769–793 (2020).
Article CAS PubMed PubMed Central Google Scholar
Steentoft, C. et al. Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology. EMBO J. 32, 1478–1488 (2013).
Article CAS PubMed PubMed Central Google Scholar
Brockhausen, I., Wandall, H. H., Hagen, K. G. T. & Stanley, P. in Essentials of Glycobiology 4th edn (eds Varki A. et al.) 117–128 (Cold Spring Harbor, 2022).
Bagdonaite, I., Pallesen, E. M. H., Nielsen, M. I., Bennett, E. P. & Wandall, H. H. Mucin-type O-GalNAc glycosylation in health and disease. Adv. Exp. Med. Biol. 1325, 25–60 (2021).
Article CAS PubMed Google Scholar
Reily, C., Stewart, T. J., Renfrow, M. B. & Novak, J. Glycosylation in health and disease. Nat. Rev. Nephrol. 15, 346–366 (2019).
Article PubMed PubMed Central Google Scholar
Dube, D. H. & Bertozzi, C. R. Glycans in cancer and inflammation—potential for therapeutics and diagnostics. Nat. Rev. Drug Discov. 4, 477–488 (2005).
Article CAS PubMed Google Scholar
Kufe, D. W. Mucins in cancer: function, prognosis and therapy. Nat. Rev. Cancer 9, 874–885 (2009).
Article CAS PubMed PubMed Central Google Scholar
Martinez-Saez, N., Peregrina, J. M. & Corzana, F. Principles of mucin structure: implications for the rational design of cancer vaccines derived from MUC1-glycopeptides. Chem. Soc. Rev. 46, 7154–7175 (2017).
Article CAS PubMed Google Scholar
Gaidzik, N., Westerlind, U. & Kunz, H. The development of synthetic antitumour vaccines from mucin glycopeptide antigens. Chem. Soc. Rev. 42, 4421–4442 (2013).
Article CAS PubMed Google Scholar
Borgert, A. et al. Deciphering structural elements of mucin glycoprotein recognition. ACS Chem. Biol. 7, 1031–1039 (2012).
Article CAS PubMed PubMed Central Google Scholar
Behren, S. et al. Fucose binding motifs on mucin core glycopeptides impact bacterial lectin recognition. Angew. Chem. Int. Ed. 62, e202302437 (2023).
Marcaurelle, L. A. & Bertozzi, C. R. Recent advances in the chemical synthesis of mucin-like glycoproteins. Glycobiology 12, 69R–77R (2002).
Bello, C. et al. Chemoenzymatic synthesis of glycopeptides to explore the role of mucin 1 glycosylation in cell adhesion. Chembiochem 24, e202200741 (2023).
Article CAS PubMed Google Scholar
Pett, C. et al. Microarray analysis of antibodies induced with synthetic antitumor vaccines: specificity against diverse mucin core structures. Chemistry 23, 3875–3884 (2017).
Article CAS PubMed Google Scholar
Pedersen, J. W. et al. Seromic profiling of colorectal cancer patients with novel glycopeptide microarray. Int. J. Cancer 128, 1860–1871 (2011).
Article CAS PubMed Google Scholar
Naito, S. et al. Generation of novel anti-MUC1 monoclonal antibodies with designed carbohydrate specificities using MUC1 glycopeptide library. ACS Omega 2, 7493–7505 (2017).
Article CAS PubMed PubMed Central Google Scholar
Wandall, H. H. et al. Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes. Cancer Res. 70, 1306–1313 (2010).
Article CAS PubMed PubMed Central Google Scholar
Takagi, J. et al. Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity. Nat. Chem. Biol. 18, 762–773 (2022).
Article CAS PubMed PubMed Central Google Scholar
Liu, D. et al. O-Glycosylation induces amyloid-beta to form new fibril polymorphs vulnerable for degradation. J. Am. Chem. Soc. 143, 20216–20223 (2021).
Article CAS PubMed Google Scholar
Jank, T. et al. Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos. Nat. Commun. 6, 7807 (2015).
Article CAS PubMed Google Scholar
Halim, A. et al. Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid. Proc. Natl Acad. Sci. USA 108, 11848–11853 (2011).
Article CAS PubMed PubMed Central Google Scholar
Steentoft, C. et al. Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines. Nat. Methods 8, 977–982 (2011).
Article CAS PubMed Google Scholar
Hounsell, E. F. et al. Structural analysis of the O-glycosidically linked core-region oligosaccharides of human meconium glycoproteins which express oncofoetal antigens. Eur. J. Biochem. 148, 367–377 (1985).
Article CAS PubMed Google Scholar
Jin, C. et al. Structural diversity of human gastric mucin glycans. Mol. Cell. Proteom. 16, 743–758 (2017).
Kurosaka, A. et al. Structures of the major oligosaccharides from a human rectal adenocarcinoma glycoprotein. J. Biol. Chem. 258, 11594–11598 (1983).
Article CAS PubMed Google Scholar
Capon, C. et al. Structures of O-glycosidically linked oligosaccharides isolated from human meconium glycoproteins. Eur. J. Biochem. 182, 139–152 (1989).
Article CAS PubMed Google Scholar
Madunic, K. et al. Specific (sialyl-)Lewis core 2 O-glycans differentiate colorectal cancer from healthy colon epithelium. Theranostics 12, 4498–4512 (2022).
Article CAS PubMed PubMed Central Google Scholar
Sumi, T. et al. Structural characterization of the trisaccharide chain from the skin mucus glycoprotein of the rainbow trout, Salmo gairdneri. Fish. Physiol. Biochem. 25, 11–17 (2001).
Jin, C. et al. Atlantic salmon carries a range of novel O-glycan structures differentially localized on skin and intestinal mucins. J. Proteome Res. 14, 3239–3251 (2015).
Article CAS PubMed Google Scholar
Padra, J. T. et al. Aeromonas salmonicida growth in response to atlantic salmon mucins differs between epithelial sites, is governed by sialylated and N-acetylhexosamine-containing O-glycans, and is affected by Ca(2). Infect. Immun. 85, e00189-17 (2017).
留言 (0)