Gao, Y. et al. Metastasis organotropism: redefining the congenial soil. Dev. Cell 49, 375–391 (2019).
Article CAS PubMed PubMed Central Google Scholar
Conod, A., Silvano, M. & Ruiz, I. A. A. On the origin of metastases: induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm. Cell Rep. 38, 110490 (2022).
Article CAS PubMed Google Scholar
Deng, J. & Fleming, J. B. Inflammation and myeloid cells in cancer progression and metastasis. Front. Cell Dev. Biol. 9, 759691 (2021).
Phan, T. G. & Croucher, P. I. The dormant cancer cell life cycle. Nat. Rev. Cancer 20, 398–411 (2020).
Article CAS PubMed Google Scholar
Heerboth, S. et al. EMT and tumor metastasis. Clin. Transl. Med. 4, 6 (2015).
Article PubMed PubMed Central Google Scholar
Gu, Y., Zhang, Z. & Ten Dijke, P. Harnessing epithelial–mesenchymal plasticity to boost cancer immunotherapy. Cell. Mol. Immunol. 20, 318–340 (2023).
Article CAS PubMed PubMed Central Google Scholar
Peinado, H., Olmeda, D. & Cano, A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7, 415–428 (2007).
Article CAS PubMed Google Scholar
Eckert, M. A. et al. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 19, 372–386 (2011).
Article CAS PubMed PubMed Central Google Scholar
Krebs, A. M. et al. The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Nat. Cell Biol. 19, 518–529 (2017).
Article CAS PubMed Google Scholar
Tang, X., Sui, X., Weng, L. & Liu, Y. SNAIL1: linking tumor metastasis to immune evasion. Front. Immunol. 12, 724200 (2021).
Article CAS PubMed PubMed Central Google Scholar
Fazilaty, H. et al. A gene regulatory network to control EMT programs in development and disease. Nat. Commun. 10, 5115 (2019).
Article PubMed PubMed Central Google Scholar
Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial–mesenchymal transitions in development and disease. Cell 139, 871–890 (2009).
Article CAS PubMed Google Scholar
Xiao, G. Y. et al. EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancer. Proc. Natl Acad. Sci. USA 120, e2220276120 (2023).
Article CAS PubMed PubMed Central Google Scholar
Taki, M. et al. Tumor immune microenvironment during epithelial–mesenchymal transition. Clin. Cancer Res. 27, 4669–4679 (2021).
Article CAS PubMed Google Scholar
Dongre, A. et al. Epithelial-to-mesenchymal transition contributes to immunosuppression in breast carcinomas. Cancer Res. 77, 3982–3989 (2017).
Article CAS PubMed PubMed Central Google Scholar
Song, W., Mazzieri, R., Yang, T. & Gobe, G. C. Translational significance for tumor metastasis of tumor-associated macrophages and epithelial–mesenchymal transition. Front. Immunol. 8, 1106 (2017).
Article PubMed PubMed Central Google Scholar
Grigoriev, I. et al. Rab6 regulates transport and targeting of exocytotic carriers. Dev. Cell 13, 305–314 (2007).
Article CAS PubMed Google Scholar
Kudo-Saito, C., Shirako, H., Takeuchi, T. & Kawakami, Y. Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 15, 195–206 (2009).
Article CAS PubMed Google Scholar
Bates, M. et al. Circulating tumour cells: the good, the bad and the ugly. Biochim. Biophys. Acta Rev. Cancer 1878, 188863 (2023).
Article CAS PubMed Google Scholar
Mullins, R. D. Z., Pal, A., Barrett, T. F., Heft Neal, M. E. & Puram, S. V. Epithelial–mesenchymal plasticity in tumor immune evasion. Cancer Res. 82, 2329–2343 (2022).
Article CAS PubMed PubMed Central Google Scholar
Aiello, N. M. et al. EMT subtype influences epithelial plasticity and mode of cell migration. Dev. Cell 45, 681–695 (2018).
Article CAS PubMed PubMed Central Google Scholar
Pastushenko, I. et al. Identification of the tumour transition states occurring during EMT. Nature 556, 463–468 (2018).
Article CAS PubMed Google Scholar
Li, W. & Kang, Y. Probing the fifty shades of EMT in metastasis. Trends Cancer 2, 65–67 (2016).
Article PubMed PubMed Central Google Scholar
Wang, G. et al. The pan-cancer landscape of crosstalk between epithelial–mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response. NPJ Precis. Oncol. 5, 56 (2021).
Article PubMed PubMed Central Google Scholar
Subhadarshini, S., Markus, J., Sahoo, S. & Jolly, M. K. Dynamics of epithelial–mesenchymal plasticity: what have single-cell investigations elucidated so far? ACS Omega 8, 11665–11673 (2023).
Article CAS PubMed PubMed Central Google Scholar
Parodi, M. et al. Hybrid epithelial–mesenchymal status of lung cancer dictates metastatic success through differential interaction with NK cells. J. Immunother. Cancer 12, e007895 (2024).
Article PubMed PubMed Central Google Scholar
Getu, A. A. et al. New frontiers in immune checkpoint B7-H3 (CD276) research and drug development. Mol. Cancer 22, 43 (2023).
Article CAS PubMed PubMed Central Google Scholar
Kroger, C. et al. Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells. Proc. Natl Acad. Sci. USA 116, 7353–7362 (2019).
Article CAS PubMed PubMed Central Google Scholar
Luond, F. et al. Distinct contributions of partial and full EMT to breast cancer malignancy. Dev. Cell 56, 3203–3221 (2021).
Article CAS PubMed Google Scholar
Yamamoto, A., Doak, A. E. & Cheung, K. J. Orchestration of collective migration and metastasis by tumor cell clusters. Annu. Rev. Pathol. 18, 231–256 (2023).
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