Tamm I, Horsfall FL Jr. Characterization and separation of an inhibitor of viral hemagglutination present in urine. Proc Soc Exp Biol Med. 1950;74(1):106–8.

Article  CAS  PubMed  Google Scholar 

Chabardès-Garonne D, Mejéan A, Aude JC, Cheval L, Di Stefano A, Gaillard MC, et al. A panoramic view of gene expression in the human kidney. Proc Natl Acad Sci U S A. 2003;100(23):13710–5.

Article  PubMed  PubMed Central  Google Scholar 

Tokonami N, Takata T, Beyeler J, Ehrbar I, Yoshifuji A, Christensen EI, et al. Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC. Kidney Int. 2018;94(4):701–15.

Article  CAS  PubMed  Google Scholar 

Pennica D, Kohr WJ, Kuang WJ, Glaister D, Aggarwal BB, Chen EY, Goeddel DV. Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein. Science. 1987;236(4797):83–8.

Article  CAS  PubMed  Google Scholar 

Easton RL, Patankar MS, Clark GF, Morris HR, Dell A. Pregnancy-associated changes in the glycosylation of tamm-horsfall glycoprotein. Expression of sialyl Lewis(x) sequences on core 2 type O-glycans derived from uromodulin. J Biol Chem. 2000;275(29):21928–38.

Article  CAS  PubMed  Google Scholar 

Micanovic R, Khan S, Janosevic D, Lee ME, Hato T, Srour EF, et al. Tamm-horsfall protein regulates mononuclear phagocytes in the kidney. J Am Soc Nephrol. 2018;29(3):841–56.

Article  CAS  PubMed  Google Scholar 

Micanovic R, LaFavers KA, Patidar KR, Ghabril MS, Doud EH, Mosley AL, et al. The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain. Am J Physiol Renal Physiol. 2022;322(4):F403–18.

Article  PubMed  PubMed Central  Google Scholar 

Schaeffer C, Devuyst O, Rampoldi L. Uromodulin: Roles in Health and Disease. Annu Rev Physiol. 2021;83:477–501.

Article  CAS  PubMed  Google Scholar 

Kipp A, Olinger E. What Does Uromodulin Do? Clin J Am Soc Nephrol. 2020;16(1):150–3.

Article  PubMed  PubMed Central  Google Scholar 

Thielemans R, Speeckaert R, Delrue C, De Bruyne S, Oyaert M, Speeckaert MM. Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases. Diagnostics (Basel). 2023;13(19):3077.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Gentilini D, et al. Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet. 2010;6(10):e1001177.

Article  PubMed  PubMed Central  Google Scholar 

Graham LA, Padmanabhan S, Fraser NJ, Kumar S, Bates JM, Raffi HS, et al. Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension. 2014;63(3):551–8.

Article  CAS  PubMed  Google Scholar 

Trudu M, Janas S, Lanzani C, Debaix H, Schaeffer C, Ikehata M, et al. Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat Med. 2013;19(12):1655–60.

Article  CAS  PubMed  Google Scholar 

Bastarache L, Denny JC, Roden DM. Phenome-wide association studies. JAMA. 2022;327(1):75–6.

Article  PubMed  PubMed Central  Google Scholar 

Akwo EA, Chen HC, Liu G, Triozzi JL, Tao R, Yu Z, et al. Phenome-Wide Association Study of UMOD Gene Variants and Differential Associations With Clinical Outcomes Across Populations in the Million Veteran Program a Multiethnic Biobank. Kidney Int Rep. 2022;7(8):1802–18.

Article  PubMed  PubMed Central  Google Scholar 

Batty GD, Gale CR, Kivimäki M, Deary IJ, Bell S. Comparison of risk factor associations in UK Biobank against representative, general population based studies with conventional response rates: prospective cohort study and individual participant meta-analysis. BMJ. 2020;368:m131.

Article  PubMed  PubMed Central  Google Scholar 

Devuyst O, Olinger E, Rampoldi L. Uromodulin: from physiology to rare and complex kidney disorders. Nat Rev Nephrol. 2017;13(9):525–44.

Article  CAS  PubMed  Google Scholar 

Boehm FJ, Zhou X. Statistical methods for Mendelian randomization in genome-wide association studies: A review. Comput Struct Biotechnol J. 2022;20:2338–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davies NM, Holmes MV, Davey SG. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;362:k601.

Article  PubMed  PubMed Central  Google Scholar 

Ponte B, Sadler MC, Olinger E, Vollenweider P, Bochud M, Padmanabhan S, et al. Mendelian randomization to assess causality between uromodulin, blood pressure and chronic kidney disease. Kidney Int. 2021;100(6):1282–91.

Article  CAS  PubMed  Google Scholar 

Turner M, Staplin N. UMOD-ulating CKD risk: untangling the relationship between urinary uromodulin, blood pressure, and kidney disease. Kidney Int. 2021;100(6):1168–70.

Article  CAS  PubMed  Google Scholar 

You R, Chen L, Xu L, Zhang D, Li H, Shi X, et al. High Level of Uromodulin Increases the Risk of Hypertension: A Mendelian Randomization Study. Front Cardiovasc Med. 2021;8:736001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903–13.

Article  PubMed  Google Scholar 

Jian Z, Yuan C, Ma Y. Blood pressure mediated the effects of urinary uromodulin levels on myocardial infarction: a mendelian randomization study. Hypertension. 2022;79(11):2430–8.

Article  CAS  PubMed  Google Scholar 

McCallum L, Lip S, McConnachie A, Brooksbank K, MacIntyre I, Doney A, Llano A, Aman A, Caparrotta TM, Ingram G, Mackenzie IS, Dominiczak AF, MacDonald TM, Webb DJ, Padmanabhan S. UMOD genotype-blinded trial of ambulatory blood pressure response to torasemide. Hypertension. 2024. https://doi.org/10.1161/HYPERTENSIONAHA.124.23122.

Visser FW, Boonstra AH, Titia Lely A, Boomsma F, Navis G. Renal response to angiotensin II is blunted in sodium-sensitive normotensive men. Am J Hypertens. 2008;21(3):323–8.

Article  CAS  PubMed  Google Scholar 

Ponte B, Pruijm M, Ackermann D, Olinger E, Youhanna S, Vogt B, et al. Uromodulin, salt, and 24-hour blood pressure in the general population. Clin J Am Soc Nephrol. 2021;16(5):787–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du MF, Yao S, Zou T, Mu JJ, Zhang XY, Hu GL, et al. Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions. J Clin Hypertens (Greenwich). 2021;23(10):1897–906.

Article  CAS  PubMed  Google Scholar 

Bakhoum CY, Anderson CAM, Juraschek SP, Rebholz CM, Appel LJ, Miller ER, et al. The relationship between urine uromodulin and blood pressure changes: the dash-sodium trial. Am J Hypertens. 2021;34(2):154–6.

Article  CAS  PubMed  Google Scholar 

GenSalt. rationale, design, methods and baseline characteristics of study participants. J Hum Hypertens. 2007;21(8):639–46.

He J, Gu D, Chen J, Jaquish CE, Rao DC, Hixson JE, et al. Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study. J Hypertens. 2009;27(1):48–54.

Article  CAS  PubMed