Berger, J. & Hinglais, N. [Intercapillary deposits of IgA-IgG]. J. Urol. Nephrol. 74, 694–695 (1968).
McGrogan, A., Franssen, C. F. M. & De Vries, C. S. The incidence of primary glomerulonephritis worldwide: a systematic review of the literature. Nephrol. Dial. Transpl. 26, 414–430 (2011).
Schena, F. P. & Nistor, I. Epidemiology of IgA nephropathy: a global perspective. Semin. Nephrol. 38, 435–442 (2018).
Knoppova, B. et al. Pathogenesis of IgA nephropathy: current understanding and implications for development of disease-specific treatment. J. Clin. Med. 10, 4501 (2021).
Article CAS PubMed PubMed Central Google Scholar
Pillebout, E. IgA vasculitis and IgA nephropathy: same disease? J. Clin. Med. 10, 2310 (2021).
Article CAS PubMed PubMed Central Google Scholar
Willey, C. J. et al. The incidence and prevalence of IgA nephropathy in Europe. Nephrol. Dial. Transpl. 38, 2340–2349 (2023).
Barbour, S. J. et al. Individuals of Pacific Asian origin with IgA nephropathy have an increased risk of progression to end-stage renal disease. Kidney Int. 84, 1017–1024 (2013).
Article CAS PubMed Google Scholar
D’Amico, G. & D’Amico, G. Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome. Semin. Nephrol. 24, 179–196 (2004).
Pitcher, D. et al. Long-term outcomes in IgA nephropathy. Clin. J. Am. Soc. Nephrol. 18, 727–738 (2023).
Article PubMed PubMed Central Google Scholar
Floege, J. Recurrent IgA nephropathy after renal transplantation. Semin. Nephrol. 24, 287–291 (2004).
Jarrick, S. et al. Mortality in IgA nephropathy: a nationwide population-based cohort study. J. Am. Soc. Nephrol. 30, 866–876 (2019).
Article PubMed PubMed Central Google Scholar
Hastings, M. C. et al. Life expectancy for patients from the Southeastern United States with IgA nephropathy. Kidney Int. Rep. 3, 99–104 (2018).
Barbour, S. J. et al. Updating the international IgA nephropathy prediction tool for use in children. Kidney Int. 99, 1439–1450 (2021).
Article CAS PubMed Google Scholar
Suzuki, H. et al. The pathophysiology of IgA nephropathy. J. Am. Soc. Nephrol. 22, 1795–1803 (2011).
Article CAS PubMed PubMed Central Google Scholar
Scionti, K., Molyneux, K., Selvaskandan, H., Barratt, J. & Cheung, C. K. New insights into the pathogenesis and treatment strategies in IgA nephropathy. Glomerular Dis. 2, 15–29 (2022).
Allen, A. C. et al. Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients. Kidney Int. 60, 969–973 (2001).
Article CAS PubMed Google Scholar
Allen, A. C., Bailey, E. M., Barratt, J., Buck, K. S. & Feehally, J. Analysis of IgA1 O-glycans in IgA nephropathy by fluorophore-assisted carbohydrate electrophoresis. J. Am. Soc. Nephrol. 10, 1763–1771 (1999).
Article CAS PubMed Google Scholar
Hiki, Y. et al. Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. Kidney Int. 59, 1077–1085 (2001).
Article CAS PubMed Google Scholar
Coppo, R. & Amore, A. Aberrant glycosylation in IgA nephropathy (IgAN). Kidney Int. 65, 1544–1547 (2004).
Article CAS PubMed Google Scholar
Xu, L. X. & Zhao, M. H. Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy. Kidney Int. 68, 167–172 (2005).
Article CAS PubMed Google Scholar
Gharavi, A. G. et al. Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy. J. Am. Soc. Nephrol. 19, 1008–1014 (2008).
Article PubMed PubMed Central Google Scholar
Tomana, M. et al. Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int. 52, 509–516 (1997).
Article CAS PubMed Google Scholar
Tomana, M. et al. Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J. Clin. Invest. 104, 73–81 (1999).
Article CAS PubMed PubMed Central Google Scholar
Knoppova, B. et al. The origin and activities of IgA1-containing immune complexes in IgA nephropathy. Front. Immunol. 7, 117 (2016).
Article PubMed PubMed Central Google Scholar
Cheung, C. K., Dormer, J. P. & Barratt, J. The role of complement in glomerulonephritis — are novel therapies ready for prime time? Nephrol. Dial. Transpl. 38, 1789–1797 (2022).
Kerr, M. A. The structure and function of human IgA. Biochem. J. 271, 285–296 (1990).
Article CAS PubMed PubMed Central Google Scholar
Barratt, J. et al. Why target the gut to treat IgA nephropathy? Kidney Int. Rep. 5, 1620–1624 (2020).
Article PubMed PubMed Central Google Scholar
Perše, M. & Večerić-Haler, Ž. The role of IgA in the pathogenesis of IgA nephropathy. Int. J. Mol. Sci. 20, 6199 (2019).
Article PubMed PubMed Central Google Scholar
He, J.-W. et al. Associations of genetic variants contributing to gut microbiota composition in immunoglobin a nephropathy. mSystems 6, e00819–e00820 (2021).
Article CAS PubMed PubMed Central Google Scholar
Zhao, J. et al. Expansion of Escherichia-Shigella in gut is associated with the onset and response to immunosuppressive therapy of IgA nephropathy. J. Am. Soc. Nephrol. 33, 2276–2292 (2022).
Article CAS PubMed PubMed Central Google Scholar
Lebreton, C. et al. Interactions among secretory immunoglobulin A, CD71, and transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptides. Gastroenterology 143, 698–707.e4 (2012).
Article CAS PubMed Google Scholar
Matysiak-Budnik, T. et al. Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. J. Exp. Med. 205, 143–154 (2008).
Article CAS PubMed PubMed Central Google Scholar
Woof, J. M. & Russell, M. W. Structure and function relationships in IgA. Mucosal Immunol. 4, 590–597 (2011).
留言 (0)