Epigenetic profiles in blood and adipose tissue: identifying strong correlations in morbidly obese and non-obese patients

Herrera BM, Keildson S, Lindgren CM (2011) Genetics and epigenetics of obesity. Maturitas 69:41–49. https://doi.org/10.1016/j.maturitas.2011.02.018

Article  PubMed  PubMed Central  Google Scholar 

Pischon T, Boeing H, Hoffmann K et al (2008) General and abdominal adiposity and risk of death in Europe. N Engl J Med 359:2105–2120. https://doi.org/10.1056/NEJMoa0801891

Article  PubMed  Google Scholar 

Samblas M, Milagro FI, Martínez A (2019) DNA methylation markers in obesity, metabolic syndrome, and weight loss. Epigenetics 14:421–444. https://doi.org/10.1080/15592294.2019.1595297

Article  PubMed  PubMed Central  Google Scholar 

Lövkvist C, Dodd IB, Sneppen K, Haerter JO (2016) DNA methylation in human epigenomes depends on local topology of CpG sites. Nucleic Acids Res 44:5123–5132. https://doi.org/10.1093/nar/gkw124

Article  PubMed  PubMed Central  Google Scholar 

Greenberg MVC, Bourc’his D (2019) The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol 20:590–607. https://doi.org/10.1038/s41580-019-0159-6

Article  PubMed  Google Scholar 

Koch A, Joosten SC, Feng Z et al (2018) Author correction: Analysis of DNA methylation in cancer: location revisited. Nat Rev Clin Oncol 15:467. https://doi.org/10.1038/s41571-018-0028-9

Article  PubMed  Google Scholar 

Unnikrishnan A, Freeman WM, Jackson J et al (2019) The role of DNA methylation in epigenetics of aging. Pharmacol Ther 195:172–185. https://doi.org/10.1016/j.pharmthera.2018.11.001

Article  PubMed  Google Scholar 

Roadmap Epigenomics Consortium, Kundaje A, Meuleman W et al (2015) Integrative analysis of 111 reference human epigenomes. Nature 518:317–330. https://doi.org/10.1038/nature14248

Article  PubMed Central  Google Scholar 

Aslibekyan S, Demerath EW, Mendelson M et al (2015) Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference. Obes Silver Spring Md 23:1493–1501. https://doi.org/10.1002/oby.21111

Article  Google Scholar 

Demerath EW, Guan W, Grove ML et al (2015) Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci. Hum Mol Genet 24:4464–4479. https://doi.org/10.1093/hmg/ddv161

Article  PubMed  PubMed Central  Google Scholar 

Dhana K, Braun KVE, Nano J et al (2018) An epigenome-wide association study of obesity-related traits. Am J Epidemiol 187:1662–1669. https://doi.org/10.1093/aje/kwy025

Article  PubMed  PubMed Central  Google Scholar 

Dick KJ, Nelson CP, Tsaprouni L et al (2014) DNA methylation and body-mass index: a genome-wide analysis. Lancet Lond Engl 383:1990–1998. https://doi.org/10.1016/S0140-6736(13)62674-4

Article  Google Scholar 

Mendelson MM, Marioni RE, Joehanes R et al (2017) Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a mendelian randomization approach. PLoS Med 14:e1002215. https://doi.org/10.1371/journal.pmed.1002215

Article  PubMed  PubMed Central  Google Scholar 

Sayols-Baixeras S, Subirana I, Fernández-Sanlés A et al (2017) DNA methylation and obesity traits: an epigenome-wide association study. The REGICOR study. Epigenetics 12:909–916. https://doi.org/10.1080/15592294.2017.1363951

Article  PubMed  PubMed Central  Google Scholar 

Wahl S, Drong A, Lehne B et al (2017) Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature 541:81–86. https://doi.org/10.1038/nature20784

Article  PubMed  Google Scholar 

Wang X, Pan Y, Zhu H et al (2018) An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression. Clin Epigenetics 10:3. https://doi.org/10.1186/s13148-017-0435-2

Article  PubMed  PubMed Central  Google Scholar 

Xu X, Su S, Barnes VA et al (2013) A genome-wide methylation study on obesity: differential variability and differential methylation. Epigenetics 8:522–533. https://doi.org/10.4161/epi.24506

Article  PubMed  PubMed Central  Google Scholar 

Huang Y-T, Chu S, Loucks EB et al (2016) Epigenome-wide profiling of DNA methylation in paired samples of adipose tissue and blood. Epigenetics 11:227–236. https://doi.org/10.1080/15592294.2016.1146853

Article  PubMed  PubMed Central  Google Scholar 

Ling C, Rönn T (2019) Epigenetics in human obesity and type 2 diabetes. Cell Metab 29:1028–1044. https://doi.org/10.1016/j.cmet.2019.03.009

Article  PubMed  PubMed Central  Google Scholar 

Hannon E, Lunnon K, Schalkwyk L, Mill J (2015) Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics 10:1024–1032. https://doi.org/10.1080/15592294.2015.1100786

Article  PubMed  PubMed Central  Google Scholar 

Walton E, Hass J, Liu J et al (2016) Correspondence of DNA methylation between blood and brain tissue and its application to schizophrenia research. Schizophr Bull 42:406–414. https://doi.org/10.1093/schbul/sbv074

Article  PubMed  Google Scholar 

Ebrahimi P, Luthman H, McGuigan FE, Akesson KE (2021) Epigenome-wide cross-tissue correlation of human bone and blood DNA methylation - can blood be used as a surrogate for bone? Epigenetics 16:92–105. https://doi.org/10.1080/15592294.2020.1788325

Article  PubMed  Google Scholar 

Rojo-Martínez G, Esteva I, de Adana SR et al (2004) Patterns of insulin resistance in the general population of southeast Spain. Diabetes Res Clin Pract 65:247–256. https://doi.org/10.1016/j.diabres.2004.01.004

Article  PubMed  Google Scholar 

Morcillo S, Cardona F, Rojo-Martínez G et al (2005) Association between MspI polymorphism of the APO AI gene and Type 2 diabetes mellitus. Diabet Med 22:782–788. https://doi.org/10.1111/j.1464-5491.2005.01514.x

Article  PubMed  Google Scholar 

Du P, Zhang X, Huang C-C et al (2010) Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics 11:587. https://doi.org/10.1186/1471-2105-11-587

Article  PubMed  PubMed Central  Google Scholar 

Izquierdo AG, Carreira MC, Boughanem H et al (2022) Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss. Eur J Clin Invest 52:e13685. https://doi.org/10.1111/eci.13685

Article  PubMed  Google Scholar 

Houde A-A, Légaré C, Biron S et al (2015) Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women. BMC Med Genet 16:29. https://doi.org/10.1186/s12881-015-0174-1

Article  PubMed  PubMed Central  Google Scholar 

Richmond RC, Sharp GC, Ward ME et al (2016) DNA methylation and BMI: investigating identified methylation sites at HIF3A in a causal framework. Diabetes 65:1231–1244. https://doi.org/10.2337/db15-0996

Article  PubMed  PubMed Central  Google Scholar 

Kuk JL, Church TS, Blair SN, Ross R (2006) Does measurement site for visceral and abdominal subcutaneous adipose tissue alter associations with the metabolic syndrome? Diabetes Care 29:679–684. https://doi.org/10.2337/diacare.29.03.06.dc05-1500

Article  PubMed  Google Scholar 

Zhang X, Chen Q, Sun X et al (2022) Association between MRI-based visceral adipose tissues and metabolic abnormality in a Chinese population: a cross-sectional study. Nutr Metab 19:16. https://doi.org/10.1186/s12986-022-00651-x

Article 

留言 (0)

沒有登入
gif