Petrov, M. S., and D. Yadav. 2019. Global epidemiology and holistic prevention of pancreatitis. Nature reviews Gastroenterology & Hepatology 16 (3): 175–184.

Article  Google Scholar 

Ding, W.X., Ma, X., Kim, S., Wang, S., and H.M. Ni. 2024. Recent insights about autophagy in pancreatitis. eGastroenterology 2(2): e100057.

Boxhoorn, L., R. P. Voermans, S. A. Bouwense, M. J. Bruno, R. C. Verdonk, M. A. Boermeester, H. C. van Santvoort, and M. G. Besselink. 2020. Acute pancreatitis. Lancet (London, England) 396 (10252): 726–734.

Article  PubMed  Google Scholar 

Das, S.L., P. P. Singh, A. R. Phillips, R. Murphy, J. A. Windsor, and M. S. Petrov. 2014. Newly diagnosed diabetes mellitus after acute pancreatitis: A systematic review and meta-analysis. Gut 63 (5): 818–831.

Article  PubMed  Google Scholar 

Gukovskaya, A.S., S. J. Pandol, and I. Gukovsky. 2016. New insights into the pathways initiating and driving pancreatitis. Current Opinion in Gastroenterology 32 (5): 429–435.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Criddle, D. N., E. McLaughlin, J. A. Murphy, O. H. Petersen, and R. Sutton. 2007. The pancreas misled: signals to pancreatitis. Pancreatology : official journal of the International Association of Pancreatology (IAP) [et al] 7 (5–6): 436–446.

Article  PubMed  Google Scholar 

Gukovskaya, A. S., I. Gukovsky, H. Algül, and A. Habtezion. 2017. Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis. Gastroenterology 153 (5): 1212–1226.

Article  CAS  PubMed  Google Scholar 

Zhang, Q., M. Raoof, Y. Chen, Y. Sumi, T. Sursal, W. Junger, K. Brohi, K. Itagaki, and C.J. Hauser. 2010. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464 (7285): 104–107.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oka, T., S. Hikoso, O. Yamaguchi, M. Taneike, T. Takeda, T. Tamai, J. Oyabu, T. Murakawa, H. Nakayama, K. Nishida, et al. 2012. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485 (7397): 251–255.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong, Z., S. Liang, E. Sanchez-Lopez, F. He, S. Shalapour, X.J. Lin, J. Wong, S. Ding, E. Seki, B. Schnabl, et al. 2018. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature 560 (7717): 198–203.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, D., Y. Oyaizu, H. Oyaizu, G.J. Olsen, and C.R. Woese. 1985. Mitochondrial origins. Proceedings of the National Academy of Sciences of the United States of America 82 (13): 4443–4447.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shimada, K., T. R. Crother, J. Karlin, J. Dagvadorj, N. Chiba, S. Chen, V. K. Ramanujan, A. J. Wolf, L. Vergnes, D. M. Ojcius, et al. 2012. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36 (3): 401–414.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishikawa, H., Z. Ma, and G. N. Barber. 2009. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461 (7265): 788–792.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ablasser, A., M. Goldeck, T. Cavlar, T. Deimling, G. Witte, I. Röhl, K.P. Hopfner, J. Ludwig, and V. Hornung. 2013. cGAS produces a 2’-5’-linked cyclic dinucleotide second messenger that activates STING. Nature 498 (7454): 380–384.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao, Q., Y. Wei, S. J. Pandol, L. Li, and A. Habtezion. 2018. STING Signaling Promotes Inflammation in Experimental Acute Pancreatitis. Gastroenterology 154 (6): 1822-1835.e1822.

Article  CAS  PubMed  Google Scholar 

Peng, Y., Yang, Y., Li, Y., Shi, T., Xu, N., Liu, R., Luan, Y., Yao, Y., Yin, C. 2024. Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis. Cellular & Molecular Biology Letters. 29(1): 61.

Chen, H., Lu, X., Xu, B., Cheng, G., Li, Y., Xie, DA-OX. Saikosaponin d protects pancreatic acinar cells against cerulein-induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS-STING pathway. LID - https://doi.org/10.1002/jat.4594 [doi]. (1099–1263 (Electronic)).

Wang, G. J., C. F. Gao, D. Wei, C. Wang, and S. Q. Ding. 2009. Acute pancreatitis: Etiology and common pathogenesis. World Journal of Gastroenterology 15 (12): 1427–1430.

Article  PubMed  PubMed Central  Google Scholar 

Zhang, W., G. Li, R. Luo, J. Lei, Y. Song, B. Wang, L. Ma, Z. Liao, W. Ke, H. Liu, et al. 2022. Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis. Experimental & Molecular Medicine 54 (2): 129–142.

Article  CAS  Google Scholar 

Stoccoro, A. A. O., Coppedè, F. Mitochondrial DNA Methylation and Human Diseases. LID - https://doi.org/10.3390/ijms22094594 LID - 4594. (1422–0067 (Electronic)).

Boyapati, R. K., A. Tamborska, D. A. Dorward, and G. T. Ho. 2017. Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases. F1000Research 6: 169.

Article  PubMed  PubMed Central  Google Scholar 

Yamanouchi, S., D. Kudo, M. Yamada, N. Miyagawa, H. Furukawa, and S. Kushimoto. 2013. Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: Time course and the association with clinical status. Journal of Critical Care 28 (6): 1027–1031.

Article  CAS  PubMed  Google Scholar 

Qin, C., J. Gu, R. Liu, F. Xu, H. Qian, Q. He, and W. Meng. 2017. Release of mitochondrial DNA correlates with peak inflammatory cytokines in patients with acute myocardial infarction. Anatolian Journal of Cardiology 17 (3): 224–228.

CAS  PubMed  Google Scholar 

Gu, X., G. Wu, Y. Yao, J. Zeng, D. Shi, T. Lv, L. Luo, and Y. Song. 2015. Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathway. Free Radical Biology & Medicine 83: 149–158.

Article  CAS  Google Scholar 

Knez, J., V. G. Marrachelli, N. Cauwenberghs, E. Winckelmans, Z. Zhang, L. Thijs, J. Brguljan-Hitij, M. Plusquin, C. Delles, D. Monleon, et al. 2017. Peripheral blood mitochondrial DNA content in relation to circulating metabolites and inflammatory markers: A population study. PLoS ONE 12 (7): e0181036.

Article  PubMed  PubMed Central  Google Scholar 

Wu, L., W. Xu, F. Wang, T. Lv, Z. Yin, and Y. Song. 2018. Plasma mtDNA Analysis Aids in Predicting Pancreatic Necrosis in Acute Pancreatitis Patients: A Pilot Study. Digestive Diseases and Sciences 63 (11): 2975–2982.

Article  CAS  PubMed  Google Scholar 

Bhatia, M. 2005. Inflammatory response on the pancreatic acinar cell injury. Scandinavian journal of surgery : SJS : Official organ for the Finnish Surgical Society and the Scandinavian Surgical Society 94 (2): 97–102.

CAS  PubMed  Google Scholar 

Banks, P. A., T. L. Bollen, C. Dervenis, H. G. Gooszen, C. D. Johnson, M. G. Sarr, G. G. Tsiotos, and S. S. Vege. 2013. Classification of acute pancreatitis–2012: Revision of the Atlanta classification and definitions by international consensus. Gut 62 (1): 102–111.

Article  PubMed  Google Scholar