A.D. Luster, R.L. Weinshank, R. Feinman et al., Molecular and biochemical characterization of a novel gamma-interferon-inducible protein. J. Biol. Chem. 263, 12036–12043 (1988)

Article  CAS  PubMed  Google Scholar 

J. Han, M. Wu, Z. Liu, Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy. Front. Immunol. 14, 1190333 (2023)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.E. Darnell, STATs and gene regulation. Science. 277, 1630–1635 (1997)

Article  CAS  PubMed  Google Scholar 

B. Arunachalam, U.T. Phan, H.J. Geuze et al., Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT). Proc Natl Acad Sci U S A. 97, 745– 50 (2000)

R.L. Lackman, A.M. Jamieson, J.M. Griffith et al., Innate immune recognition triggers secretion of lysosomal enzymes by macrophages. Traffic. 8, 1179–1189 (2007)

Article  CAS  PubMed  Google Scholar 

H. Phipps-Yonas, H. Cui, N. Sebastiao et al., Low GILT expression is Associated with poor patient survival in diffuse large B-Cell lymphoma. Front. Immunol. 4, 425 (2013)

Article  PubMed  PubMed Central  Google Scholar 

P.W. O’donnell, A. Haque, M.J. Klemsz et al., Cutting edge: induction of the antigen-processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells is STAT1-dependent but CIITA-independent. J. Immunol. 173, 731–735 (2004)

Article  PubMed  Google Scholar 

K.T. Hastings, Shaping the MHC class II-Restricted peptidome and CD4(+) T cell-mediated immunity. Front. Immunol. 4, 429 (2013)

Article  PubMed  PubMed Central  Google Scholar 

K.T. Hastings, R.L. Lackman, P. Cresswell, Functional requirements for the lysosomal thiol reductase GILT in MHC class II-restricted antigen processing. J. Immunol. 177, 8569–8577 (2006)

Article  CAS  PubMed  Google Scholar 

J.D. Hathaway-Schrader, D. Norton, K. Hastings et al., GILT expression in human melanoma cells enhances Generation of antigenic peptides for HLA class II-Mediated Immune Recognition. Int. J. Mol. Sci. 23, (2022)

A.C. Adams, E.S. Borden, A.M. Macy et al., High GILT expression is Associated with Improved Survival in metastatic melanoma patients treated with Immune Checkpoint Inhibition. Cancers (Basel) 14, (2022)

J. Nguyen, R. Bernert, Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma. Melanoma Res. 26, 125–137 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Chen, Q. Wang, X. Shao et al., Lentivirus mediated γ-interferon-inducible lysosomal thiol reductase (GILT) knockdown suppresses human glioma U373MG cell proliferation. Biochem. Biophys. Res. Commun. 509, 182–187 (2019)

Article  CAS  PubMed  Google Scholar 

C. Ye, W. Zhou, F. Wang et al., Prognostic value of gamma-interferon-inducible lysosomal thiol reductase expression in female patients diagnosed with breast cancer. Int. J. Cancer. 150, 705–717 (2022)

Article  CAS  PubMed  Google Scholar 

Y.-J. Xiang, M.-M. Guo, C.-J. Zhou et al., Absence of gamma-interferon-inducible lysosomal thiol reductase (GILT) is associated with poor disease-free survival in breast cancer patients. PloS One 9, e109449 (2014)

U.T. Phan, B. Arunachalam, P. Cresswell, Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action. J. Biol. Chem. 275, 25907–25914 (2000)

Article  CAS  PubMed  Google Scholar 

K.T. Hastings, P. Cresswell, Disulfide reduction in the endocytic pathway: immunological functions of gamma-interferon-inducible lysosomal thiol reductase. Antioxid. Redox Signal. 15, 657–668 (2011)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Maric, B. Arunachalam, U.T. Phan et al., Defective antigen processing in GILT-free mice. Science. 294, 1361–1365 (2001)

Article  CAS  PubMed  Google Scholar 

K. Honey, M. Duff, C. Beers et al., Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes. J. Biol. Chem. 276, 22573–22578 (2001)

Article  CAS  PubMed  Google Scholar 

R.L. Lackman, P. Cresswell, Exposure of the promonocytic cell line THP-1 to Escherichia coli induces IFN-gamma-inducible lysosomal thiol reductase expression by inflammatory cytokines. J. Immunol. 177, 4833–4840 (2006)

Article  CAS  PubMed  Google Scholar 

C. Watts, Immunology. Antigen presentation–losing its shine in the absence of GILT. Science. 294, 1294–1295 (2001)

Article  CAS  PubMed  Google Scholar 

O.G. Goldstein, L.M. Hajiaghamohseni, S. Amria et al., Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma. Cancer Immunol. Immunother. 57, 1461–1470 (2008)

Article  CAS  PubMed  PubMed Central  Google Scholar 

R. Singh, P. Cresswell, Defective cross-presentation of viral antigens in GILT-free mice. Science. 328, 1394–1398 (2010)

Article  CAS  PubMed  PubMed Central  Google Scholar 

P. Srinivasan, M. Maric, Signal transducer and activator of transcription 1 negatively regulates constitutive gamma interferon-inducible lysosomal thiol reductase expression. Immunology. 132, 209–216 (2011)

Article  CAS  PubMed  PubMed Central  Google Scholar 

C. Watts, Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 15, 821–850 (1997)

Article  CAS  PubMed  Google Scholar 

D.S. Collins, E.R. Unanue, C.V. Harding, Reduction of disulfide bonds within lysosomes is a key step in antigen processing. J. Immunol. 147, 4054–4059 (1991)

Article  CAS  PubMed  Google Scholar 

M.A. Haque, P. Li, S.K. Jackson et al., Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes. J. Exp. Med. 195, 1267–1277 (2002)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.P. Rausch, K.R. Irvine, P.A. Antony et al., GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1. J. Immunol. 185, 2828–2835 (2010)

Article  CAS  PubMed  Google Scholar 

A.L. Ackerman, P. Cresswell, Cellular mechanisms governing cross-presentation of exogenous antigens. Nat. Immunol. 5, 678–684 (2004)

Article  CAS  PubMed  Google Scholar 

H. Li, Y. Wang, M. Ma et al., GILT in tumor cells improves T cell-mediated anti-tumor immune surveillance. Immunol. Lett. 234, (2021)

I. Barjaktarević, A. Rahman, S. Radoja et al., Inhibitory role of IFN-gamma-inducible lysosomal thiol reductase in T cell activation. J. Immunol. 177, 4369–4375 (2006)

Article  PubMed  Google Scholar 

M. Maric, I. Barjaktarevic, B. Bogunovic et al., Cutting edge: developmental up-regulation of IFN-gamma-inducible lysosomal thiol reductase expression leads to reduced T cell sensitivity and less severe autoimmunity. J. Immunol. 182, 746–750 (2009)

Article  CAS  PubMed  Google Scholar 

J.P. Allison, B.W. Mcintyre, D. Bloch, Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. 1982. J. Immunol. 174, 1144–1151 (2005)

CAS  PubMed  Google Scholar 

K. Haskins, R. Kubo, J. White et al., The major histocompatibility complex-restricted antigen receptor on T cells. I. isolation with a monoclonal antibody. J. Exp. Med. 157, 1149–1169 (1983)

Article  CAS  PubMed  Google Scholar 

T. Finkel, Oxidant signals and oxidative stress. Curr. Opin. Cell. Biol. 15, 247–254 (2003)