Nair N. Epidemiology and pathogenesis of heart failure with preserved ejection fraction. Rev Cardiovasc Med. 2020;21(4):531–40.
Savarese G, Vedin O, D'Amario D, et al. Prevalence and prognostic implications of longitudinal ejection fraction change in heart failure. JACC Heart Fail. 2019;7(4):306–17.
Cuijpers I, Simmonds SJ, van Bilsen M, et al. Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities. Basic Res Cardiol. 2020;115(4):39.
Article PubMed PubMed Central Google Scholar
Boengler K, Leybaert L, Ruiz-Meana M, Schulz R. Connexin 43 in mitochondria: what do we really know about its function? Front Physiol. 2022;13:928934.
Article PubMed PubMed Central Google Scholar
Shin KT, Nie ZW, Zhou W, et al. Connexin 43 knockdown induces mitochondrial dysfunction and affects early developmental competence in porcine embryos. Microsc Microanal. 2020;26(2):287–96.
Article CAS PubMed Google Scholar
Yi DG, Hong S, Huh WK. Mitochondrial dysfunction reduces yeast replicative lifespan by elevating RAS-dependent ROS production by the ER-localized NADPH oxidase Yno1. PLoS One. 2018;13(6):e0198619.
Article PubMed PubMed Central Google Scholar
Mishra S, Kass DA. Cellular and molecular pathobiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2021;18(6):400–23.
Article PubMed PubMed Central Google Scholar
Bode D, Wen Y, Hegemann N, et al. Oxidative stress and inflammatory modulation of Ca(2+) handling in metabolic HFpEF-related left atrial cardiomyopathy. Antioxidants (Basel). 2020;9(9):860.
Article CAS PubMed PubMed Central Google Scholar
Zhu J, Xiong Y, Zhang Y, et al. The molecular mechanisms of regulating oxidative stress-induced ferroptosis and therapeutic strategy in tumors. Oxidative Med Cell Longev. 2020;2020:8810785.
Kajarabille N, Latunde-Dada GO. Programmed cell-death by ferroptosis: antioxidants as mitigators. Int J Mol Sci. 2019;20(19):4968.
Article CAS PubMed PubMed Central Google Scholar
Liu B, Zhao C, Li H, et al. Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis. Biochem Biophys Res Commun. 2018;497(1):233–40.
Article CAS PubMed Google Scholar
Wagner S, Schürmann S, Hein S, Schüttler J, Friedrich O. Septic cardiomyopathy in rat LPS-induced endotoxemia: relative contribution of cellular diastolic Ca(2+) removal pathways, myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan. Basic Res Cardiol. 2015;110(5):507.
Article CAS PubMed Google Scholar
Efentakis P, Varela A, Chavdoula E, et al. Levosimendan prevents doxorubicin-induced cardiotoxicity in time- and dose-dependent manner: implications for inotropy. Cardiovasc Res. 2020;116(3):576–91.
Article CAS PubMed Google Scholar
Yu L, Yuan K, Park BM, Kim SH. Modification of levosimendan-induced suppression of atrial natriuretic peptide secretion in hypertrophied rat atria. Eur J Pharmacol. 2018;829:54–62.
Article CAS PubMed Google Scholar
Rodríguez-González R, Pollesello P, Baluja A, Álvarez J. Effects of Levosimendan on inflammation and oxidative stress pathways in a lipopolysaccharide-stimulated human endothelial cell model. Biol Res Nurs. 2019;21(5):466–72.
Zhao L, Tian L, Wang S, et al. Levosimendan in rats decreases acute kidney injury after cardiopulmonary resuscitation by improving mitochondrial dysfunction. Transl Androl Urol. 2021;10(7):3010–20.
Article PubMed PubMed Central Google Scholar
Burkhoff D, Borlaug BA, Shah SJ, et al. Levosimendan improves hemodynamics and exercise tolerance in PH-HFpEF: results of the randomized placebo-controlled HELP trial. JACC Heart Fail. 2021;9(5):360–70.
Kim S-N, Kwon H-J, Im S-W, et al. Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue. Sci Rep. 2017;7(1):7159.
Article PubMed PubMed Central Google Scholar
Akhmedov AT, Rybin V, Marín-García J. Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart. Heart Fail Rev. 2015;20(2):227–49.
Article CAS PubMed Google Scholar
Dikalova AE, Pandey A, Xiao L, et al. Mitochondrial deacetylase Sirt3 reduces vascular dysfunction and hypertension while Sirt3 depletion in essential hypertension is linked to vascular inflammation and oxidative stress. Circ Res. 2020;126(4):439–52.
Article CAS PubMed Google Scholar
Ren JX, Li C, Yan XL, et al. Crosstalk between oxidative stress and ferroptosis/oxytosis in ischemic stroke: possible targets and molecular mechanisms. Oxidative Med Cell Longev. 2021;2021:6643382.
Schiattarella GG, Altamirano F, Tong D, et al. Nitrosative stress drives heart failure with preserved ejection fraction. Nature. 2019;568(7752):351–6.
Article CAS PubMed PubMed Central Google Scholar
Lam CSP, Arnott C, Beale AL, et al. Sex differences in heart failure. Eur Heart J. 2019;40(47):3859–68c.
MacDonald MR, Petrie MC, Varyani F, et al. Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: An analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme. Eur Heart J. 2008;29(11):1377–85.
Ilieșiu AM, Hodorogea AS. Treatment of heart failure with preserved ejection fraction. Adv Exp Med Biol. 2018;1067:67–87.
Adam M, Meyer S, Knors H, et al. Levosimendan displays anti-inflammatory effects and decreases MPO bioavailability in patients with severe heart failure. Sci Rep. 2015;5:9704.
Article CAS PubMed PubMed Central Google Scholar
Obokata M, Kane GC, Reddy YN, et al. Role of diastolic stress testing in the evaluation for heart failure with preserved ejection fraction: a simultaneous invasive-echocardiographic study. Circulation. 2017;135(9):825–38.
Homme RP, Zheng Y, Smolenkova I, Singh M, Tyagi SC. Remote hind-limb ischemia mechanism of preserved ejection fraction during heart failure. Front Physiol. 2021;12:745328.
Article PubMed PubMed Central Google Scholar
Zhao Y, Wang C, Hong X, et al. Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome. Kidney Int. 2019;95(4):815–29.
Article CAS PubMed PubMed Central Google Scholar
Edwards DN, Salmeron K, Lukins DE, et al. Integrin α5β1 inhibition by ATN-161 reduces neuroinflammation and is neuroprotective in ischemic stroke. J Cereb Blood Flow Metab. 2020;40(8):1695–708.
Article CAS PubMed Google Scholar
Ji M, Cheng J, Zhang D. Oxycodone protects cardiac microvascular endothelial cells against ischemia/reperfusion injury by binding to sigma-1 receptor. Bioengineered. 2022;13(4):9628–44.
Article CAS PubMed PubMed Central Google Scholar
Epifantseva I, Shaw RM. Intracellular trafficking pathways of Cx43 gap
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