Ali I, Wani WA, Saleem K, Hsieh M-F. Anticancer metallodrugs of glutamic acid sulphonamides: in silico, DNA binding, hemolysis and anticancer studies. RSC Adv. 2014;4(56):29629–41.

Article  CAS  Google Scholar 

Ali I, Wani WA, Haque A, Saleem K. Glutamic acid and its derivatives: candidates for rational design of anticancer drugs. Future Med Chem. 2013;5(8):961–78.

Article  CAS  PubMed  Google Scholar 

Ali I, Aboul-Enein YH, Ghanem A. Enantioselective toxicity and carcinogenesis. Curr Pharm Anal. 2005;1(1):109–25.

Article  CAS  Google Scholar 

Koyama M, Mukhopadhyay P, Schuster IS, Henden AS, Hülsdünker J, Varelias A, Vetizou M, Kuns RD, Robb RJ, Zhang P, et al. MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota. Immunity. 2019;51(5):885-898.e887.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali I, Wani WA, Khan A, Haque A, Ahmad A, Saleem K, Manzoor N. Synthesis and synergistic antifungal activities of a pyrazoline based ligand and its copper(II) and nickel(II) complexes with conventional antifungals. Microb Pathog. 2012;53(2):66–73.

Article  CAS  PubMed  Google Scholar 

Lin D, Hu B, Li P, Zhao Y, Xu Y, Wu D. Roles of the intestinal microbiota and microbial metabolites in acute GVHD. Exp Hematol Oncol. 2021;10(1):49.

Article  PubMed  PubMed Central  Google Scholar 

Hill GR, Teshima T, Gerbitz A, Pan L, Cooke KR, Brinson YS, Crawford JM, Ferrara JL. Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. J Clin Invest. 1999;104(4):459–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrara JLM, Levine JE. A new approach to therapy for acute GVHD. Cell Ther Transplant. 2008;1(1):25–7.

CAS  Google Scholar 

Zhao C, Zhang Y, Zheng H. The effects of interferons on allogeneic T cell response in GVHD: the multifaced biology and epigenetic regulations. Front Immunol. 2021;12: 717540.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lindner S, Miltiadous O, Ramos RJF, Paredes J, Kousa AI, Dai A, Fei T, Lauder E, Frame J, Waters NR, et al. Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease. Nat Microbiol. 2024;9(3):614–30.

Article  CAS  PubMed  Google Scholar 

Koyama M, Hippe DS, Srinivasan S, Proll SC, Miltiadous O, Li N, Zhang P, Ensbey KS, Hoffman NG, Schmidt CR, et al. Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity. Immunity. 2023;56(8):1876-1893.e1878.

Article  CAS  PubMed  Google Scholar 

Gao F, Wu H, Wang L, Zhao Y, Huang H. Altered intestinal microbiome and epithelial damage aggravate intestinal graft-versus-host disease. Gut Microbes. 2023;15(1):2221821.

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Zhang Z, Sun N, Li J, Ma Z, Rao Z, Sun X, Zeng Q, Wu Y, Li J, et al. Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs-NLRC4 association. EMBO Rep. 2022;23(9): e54611.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qing F, Liu Z. Interferon regulatory factor 7 in inflammation, cancer and infection. Front Immunol. 2023;14:1190841.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng H, Zhang YB, Gui JF, Lemon SM, Yamane D. Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses. PLoS Pathog. 2021;17(1): e1009220.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian Y, Meng L, Wang Y, Li B, Yu H, Zhou Y, Bui T, Abraham C, Li A, Zhang Y, et al. Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction. J Clin Invest. 2021. https://doi.org/10.1172/JCI136774.

Article  PubMed  PubMed Central  Google Scholar 

Li Q, Lan P. Activation of immune signals during organ transplantation. Signal Transduct Target Ther. 2023;8(1):110.

Article  PubMed  PubMed Central  Google Scholar 

Gupta P, Barthwal MK. IL-1 β genesis: the art of regulating the regulator. Cell Mol Immunol. 2018;15(11):998–1000.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shrestha B, Walton K, Reff J, Sagatys EM, Tu N, Boucher J, Li G, Ghafoor T, Felices M, Miller JS, et al. Human CD83-targeted chimeric antigen receptor T cells prevent and treat graft-versus-host disease. J Clin Investig. 2020;130(9):4652–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holtan SG, Savid-Frontera C, Walton K, Eaton AA, Demorest C, Hoeschen A, Zhang L, Reid K, Kurian T, Sayegh Z, et al. Human effectors of acute and chronic GVHD overexpress CD83 and predict mortality. Clin Cancer Res. 2023;29(6):1114–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tabellini L, Fan W, Zhao LP, Hansen JA. Identifying biomarkers for acute GVHD. Blood. 2006;108(11):38–38.

Article  Google Scholar 

Son YM, Ahn SM, Jang MS, Moon YS, Kim SH, Cho KK, Han SH, Yun CH. Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus. Biochem Biophys Res Commun. 2008;376(3):599–604.

Article  CAS  PubMed  Google Scholar 

Son YM, Ahn SM, Kim GR, Moon YS, Kim SH, Park YM, Lee WK, Min TS, Han SH, Yun CH. Resistin enhances the expansion of regulatory T cells through modulation of dendritic cells. BMC Immunol. 2010;11:33.

Article  PubMed  PubMed Central  Google Scholar 

Propheter DC, Chara AL, Harris TA, Ruhn KA, Hooper LV. Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium. Proc Natl Acad Sci USA. 2017;114(42):11027–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tarkowski A, Bjersing J, Shestakov A, Bokarewa MI. Resistin competes with lipopolysaccharide for binding to toll-like receptor 4. J Cell Mol Med. 2010;14(6b):1419–31.

Article  CAS  PubMed  Google Scholar 

Cui W, Guo M, Liu D, Xiao P, Yang C, Huang H, Liang C, Yang Y, Fu X, Zhang Y, et al. Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition. Nat Cell Biol. 2024;26(1):124–37.

Article  CAS  PubMed  Google Scholar 

Zhang H, Yang Z, Yuan W, Liu J, Luo X, Zhang Q, Li Y, Chen J, Zhou Y, Lv J, et al. Sustained AhR activity programs memory fate of early effector CD8+ T cells. Proc Natl Acad Sci. 2024;121(11): e2317658121.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Zhou N, Zhou L, Wang J, Zhou Y, Zhang T, Fang Y, Deng J, Gao Y, Liang X, et al. IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor. Nat Immunol. 2021;22(3):358–69.

Article  CAS  PubMed  Google Scholar 

Campesato LF, Budhu S, Tchaicha J, Weng C-H, Gigoux M, Cohen IJ, Redmond D, Mangarin L, Pourpe S, Liu C, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by l-kynurenine. Nat Commun. 2020;11(1):4011.

Article  CAS  PubMed