EZH2-H3K27me3-Mediated Epigenetic Silencing of DKK1 Induces Nucleus Pulposus Cell Pyroptosis in Intervertebral Disc Degeneration by Activating NLRP3 and NAIP/NLRC4

Novais, E.J., V.A. Tran, S.N. Johnston, K.R. Darris, A.J. Roupas, G.A. Sessions, I.M. Shapiro, B.O. Diekman, and M.V. Risbud. 2021. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nature Communications 12: 5213. https://doi.org/10.1038/s41467-021-25453-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xin, J., Y. Wang, Z. Zheng, S. Wang, S. Na, and S. Zhang. 2022. Treatment of intervertebral disc degeneration. Orthopaedic Surgery 14: 1271–1280. https://doi.org/10.1111/os.13254.

Article  PubMed  PubMed Central  Google Scholar 

Bermudez-Lekerika, P., K.B. Crump, S. Tseranidou, A. Nüesch, E. Kanelis, A. Alminnawi, L. Baumgartner, E. Muñoz-Moya, R. Compte, F. Gualdi, L.G. Alexopoulos, L. Geris, K. Wuertz-Kozak, C.L. Le Maitre, J. Noailly, and B. Gantenbein. 2022. Immuno-modulatory effects of intervertebral disc cells. Frontiers in Cell and Developmental Biology 10: 924692. https://doi.org/10.3389/fcell.2022.924692.

Article  PubMed  PubMed Central  Google Scholar 

Mohd Isa, I.L., S.L. Teoh, N.H. Mohd Nor, and S.A. Mokhtar. 2022. Discogenic low back pain: Anatomy, pathophysiology and treatments of intervertebral disc degeneration. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms24010208.

Article  PubMed  PubMed Central  Google Scholar 

Liang, H., R. Luo, G. Li, W. Zhang, Y. Song, and C. Yang. 2022. The proteolysis of ECM in intervertebral disc degeneration. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms23031715.

Article  PubMed  PubMed Central  Google Scholar 

Zhang, W., Y. Gong, X. Zheng, J. Qiu, T. Jiang, L. Chen, F. Lu, X. Wu, F. Cheng, and Z. Hong. 2021. Platelet-derived growth factor-bb inhibits intervertebral disc degeneration via suppressing pyroptosis and activating the MAPK signaling pathway. Frontiers in Pharmacology 12: 799130. https://doi.org/10.3389/fphar.2021.799130.

Article  CAS  PubMed  Google Scholar 

Ge, Y., Y. Chen, C. Guo, H. Luo, F. Fu, W. Ji, C. Wu, and H. Ruan. 2022. Pyroptosis and intervertebral disc degeneration: mechanistic insights and therapeutic implications. Journal of Inflammation Research 15: 5857–5871. https://doi.org/10.2147/jir.S382069.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chao-Yang, G., C. Peng, and Z. Hai-Hong. 2021. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis Cartilage 29: 793–801. https://doi.org/10.1016/j.joca.2021.02.204.

Article  CAS  PubMed  Google Scholar 

Luo, J., Y. Yang, X. Wang, X. Chang, and S. Fu. 2022. Role of pyroptosis in intervertebral disc degeneration and its therapeutic implications. Biomolecules. https://doi.org/10.3390/biom12121804.

Article  PubMed  PubMed Central  Google Scholar 

Tang, G., X. Han, Z. Lin, H. Qian, B. Chen, C. Zhou, Y. Chen, and W. Jiang. 2021. Propionibacterium acnes accelerates intervertebral disc degeneration by inducing pyroptosis of nucleus pulposus cells via the ROS-NLRP3 pathway. Oxidative Medicine and Cellular Longevity 2021: 4657014. https://doi.org/10.1155/2021/4657014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, J., J. Zhang, Y. Zhang, W. Liu, W. Ni, X. Huang, J. Yuan, B. Zhao, H. Xiao, and F. Xue. 2020. Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis. Journal of Cellular and Molecular Medicine 24: 11742–11754. https://doi.org/10.1111/jcmm.15784.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma, H., C. Xie, Z. Chen, G. He, Z. Dai, H. Cai, H. Zhang, H. Lu, H. Wu, X. Hu, K. Zhou, G. Zheng, H. Xu, and C. Xu. 2022. MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis. Cell Death Discovery 8: 209. https://doi.org/10.1038/s41420-022-01002-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao, S.S., F. Cao, N.B. Sam, H.M. Li, Y.T. Feng, J. Ni, P. Wang, X.M. Li, and H.F. Pan. 2022. Dickkopf-1 as a promising therapeutic target for autoimmune diseases. Clinical Immunology 245: 109156. https://doi.org/10.1016/j.clim.2022.109156.

Article  CAS  PubMed  Google Scholar 

Ramli, F.F., and K.Y. Chin. 2020. A review of the potential application of osteocyte-related biomarkers, fibroblast growth factor-23, sclerostin, and dickkopf-1 in predicting osteoporosis and fractures. Diagnostics (Basel). https://doi.org/10.3390/diagnostics10030145.

Article  PubMed  Google Scholar 

Wu, Z.L., Q.Q. Xie, T.C. Liu, X. Yang, G.Z. Zhang, and H.H. Zhang. 2021. Role of the Wnt pathway in the formation, development, and degeneration of intervertebral discs. Pathology, Research and Practice 220: 153366. https://doi.org/10.1016/j.prp.2021.153366.

Article  PubMed  Google Scholar 

Kroon, T., N. Bhadouria, P. Niziolek, D. Edwards 3rd., R. Choi, E.L. Clinkenbeard, A. Robling, and N. Holguin. 2022. Suppression of Sost/Sclerostin and Dickkopf-1 Augment Intervertebral Disc Structure in Mice. Journal of Bone and Mineral Research 37: 1156–1169. https://doi.org/10.1002/jbmr.4546.

Article  CAS  PubMed  Google Scholar 

Xu, X., X. Lan, S. Fu, Q. Zhang, F. Gui, Q. Jin, L. Xie, and Y. Xiong. 2022. Dickkopf-1 exerts protective effects by inhibiting PANoptosis and retinal neovascularization in diabetic retinopathy. Biochemical and Biophysical Research Communications 617: 69–76. https://doi.org/10.1016/j.bbrc.2022.05.001.

Article  CAS  PubMed  Google Scholar 

Duan, R., W. Du, and W. Guo. 2020. EZH2: A novel target for cancer treatment. Journal of Hematology & Oncology 13: 104. https://doi.org/10.1186/s13045-020-00937-8.

Article  CAS  Google Scholar 

Weng, H.R., K. Taing, L. Chen, and A. Penney. 2023. EZH2 methyltransferase regulates neuroinflammation and neuropathic pain. Cells. https://doi.org/10.3390/cells12071058.

Article  PubMed  PubMed Central  Google Scholar 

Jiang, Y., C. Xiang, F. Zhong, Y. Zhang, L. Wang, Y. Zhao, J. Wang, C. Ding, L. Jin, F. He, and H. Wang. 2021. Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis. Theranostics 11: 361–378. https://doi.org/10.7150/thno.46360.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, C., L. Liu, M. Yang, B. Li, J. Yi, X. Ai, Y. Zhang, B. Huang, C. Li, C. Feng, and Y. Zhou. 2020. A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration. Cell Division 15: 2. https://doi.org/10.1186/s13008-020-0060-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang, C., Q. Guo, Y. Jin, J.J. Xu, Z.M. Sun, D.C. Zhu, J.H. Lin, N.F. Tian, L.J. Sun, X.L. Zhang, and Y.S. Wu. 2019. Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9. eBioMedicine 48: 619–629. https://doi.org/10.1016/j.ebiom.2019.10.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, H., G. Hou, J. Yang, W. Chen, L. Guo, Q. Mao, J. Ge, and X. Zhang. 2020. SOX9-activated PXN-AS1 promotes the tumorigenesis of glioblastoma by EZH2-mediated methylation of DKK1. Journal of Cellular and Molecular Medicine 24: 6070–6082. https://doi.org/10.1111/jcmm.15189.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, J., W.Y. Li, Y. Yang, L.Z. Yan, S.Y. Zhang, J. He, and J.X. Wang. 2019. LncRNA XIST facilitates cell growth, migration and invasion via modulating H3 histone methylation of DKK1 in neuroblastoma. Cell Cycle 18: 1882–1892. https://doi.org/10.1080/15384101.2019.1632134.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma, Z., P. Tang, W. Dong, Y. Lu, B. Tan, N. Zhou, J. Hao, J. Shen, and Z. Hu. 2022. SIRT1 alleviates IL-1β induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration. International Immunopharmacology 107: 108671. https://doi.org/10.1016/j.intimp.2022.108671.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif