Akira, S. 2013. Pathogen recognition receptors and innate immunity. Xenotransplantation 20 (5): 351–351.

Google Scholar 

Zhang, Y., and C. Liang. 2016. Innate recognition of microbial-derived signals in immunity and inflammation. Sci China Life Sci. 59 (12): 1210–1217.

Article  CAS  PubMed  Google Scholar 

Alandijany, T. 2019. Host Intrinsic and Innate Intracellular Immunity During Herpes Simplex Virus Type 1 (HSV-1) Infection. Frontiers in Microbiology 10: 2611.

Article  PubMed  PubMed Central  Google Scholar 

Hertzog, J., and J. Rehwinkel. 2020. Regulation and inhibition of the DNA sensor cGAS. EMBO Reports 21 (12): e51345.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hopfner, K.P., and V. Hornung. 2020. Molecular mechanisms and cellular functions of cGAS-STING signalling. Nature Reviews Molecular Cell Biology 21 (9): 501–521.

Article  CAS  PubMed  Google Scholar 

Zhang, B.C., R. Nandakumar, L.S. Reinert, J. Huang, A. Laustsen, et al. 2020. STEEP mediates STING ER exit and activation of signaling. Nature Immunology 21 (8): 868–879.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong, B., Y. Yang, S. Li, Y.Y. Wang, Y. Li, et al. 2008. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29 (4): 538–550.

Article  CAS  PubMed  Google Scholar 

Motwani, M., S. Pesiridis, and K.A. Fitzgerald. 2019. DNA sensing by the cGAS-STING pathway in health and disease. Nature Reviews Genetics 20 (11): 657–674.

Article  CAS  PubMed  Google Scholar 

Zhang, X., X.C. Bai, and Z.J. Chen. 2020. Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway. Immunity 53 (1): 43–53.

Article  CAS  PubMed  Google Scholar 

You, H., Y. Lin, F. Lin, M. Yang, J. Li, et al. 2020. beta-Catenin is required for the cGAS/STING signaling pathway but antagonized by the Herpes Simplex Virus 1 US3 Protein. Journal of Virology 94 (5).

Zhu, H., R. Zhang, L. Yi, Y.D. Tang, and C. Zheng. 2022. UNC93B1 attenuates the cGAS-STING signaling pathway by targeting STING for autophagy-lysosome degradation. Journal of Medical Virology 94 (9): 4490–4501.

Article  CAS  PubMed  Google Scholar 

Liu, J., C. Qian, and X. Cao. 2016. Post-Translational Modification Control of Innate Immunity. Immunity 45 (1): 15–30.

Article  PubMed  Google Scholar 

Zhang, R., W. Yang, H. Zhu, J. Zhai, M. Xue, et al. 2023. NLRC4 promotes the cGAS-STING signaling pathway by facilitating CBL-mediated K63-linked polyubiquitination of TBK1. Journal of Medical Virology 95 (8): e29013.

Article  CAS  PubMed  Google Scholar 

Davis, M.E., and M.U. Gack. 2015. Ubiquitination in the antiviral immune response. Virology 479: 52–65.

Article  PubMed  Google Scholar 

Zinngrebe, J., A. Montinaro, N. Peltzer, and H. Walczak. 2014. Ubiquitin in the immune system. EMBO Reports 15 (1): 28–45.

Article  CAS  PubMed  Google Scholar 

Zhou, Y., C. He, L. Wang, and B. Ge. 2017. Post-translational regulation of antiviral innate signaling. European Journal of Immunology 47 (9): 1414–1426.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park, Y., H.S. Jin, D. Aki, J. Lee, and Y.C. Liu. 2014. The ubiquitin system in immune regulation. Advances in Immunology 124: 17–66.

Article  PubMed  Google Scholar 

Grumati, P., and I. Dikic. 2018. Ubiquitin signaling and autophagy. Journal of Biological Chemistry. 293 (15): 5404–5413.

Article  CAS  PubMed  Google Scholar 

Yang, B., J. Pei, C. Lu, Y. Wang, M. Shen, et al. 2023. RNF144A promotes antiviral responses by modulating STING ubiquitination. EMBO Rep. 6 24 (12): e57528.

Article  CAS  Google Scholar 

Bhat, S.A., Z. Vasi, R. Adhikari, A. Gudur, A. Ali, et al. 2022. Ubiquitin proteasome system in immune regulation and therapeutics. Current Opinion in Pharmacology 67: 102310.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joazeiro, C.A.P., and A.M. Weissman. 2000. RING finger proteins: Mediators of ubiquitin ligase activity. Cell 102 (5): 549–552.

Article  CAS  PubMed  Google Scholar 

Finley, D. 2009. Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome. Annual Review of Biochemistry. 78: 477–513.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berndsen, C.E., and C. Wolberger. 2014. New insights into ubiquitin E3 ligase mechanism. Nature Structural & Molecular Biology. 21 (4): 301–307.

Article  CAS  Google Scholar 

Tsuchida, T., J. Zou, T. Saitoh, H. Kumar, T. Abe, et al. 2010. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33 (5): 765–776.

Article  CAS  PubMed  Google Scholar 

Zhang, J., M.M. Hu, Y.Y. Wang, and H.B. Shu. 2012. TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. Journal of Biological Chemistry 287 (34): 28646–28655.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong, B., Y. Zhang, B. Tan, T.T. Liu, Y.Y. Wang, et al. 2010. The E3 Ubiquitin Ligase RNF5 Targets Virus-Induced Signaling Adaptor for Ubiquitination and Degradation. Journal of Immunology 184 (11): 6249–6255.

Article  CAS  Google Scholar 

Kong, Z., H. Yin, F. Wang, Z. Liu, X. Luan, et al. 2022. Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity. PLoS Pathogens 18 (5): e1010544.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, X., Z. Yu, Q. Fang, M. Yang, J. Huang, et al. 2022. The transmembrane endoplasmic reticulum-associated E3 ubiquitin ligase TRIM13 restrains the pathogenic-DNA-triggered inflammatory response. Science Advances 8 (4): eabh0496.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun, N., L. Jiang, M. Ye, Y. Wang, G. Wang, et al. 2020. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Protein & Cell 11 (12): 894–914.

Article  CAS  Google Scholar 

Liu, S., X. Cai, J. Wu, Q. Cong, X. Chen, et al. 2015. Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 (6227): aaa2630.

Article  PubMed  Google Scholar 

You, H., S. Zheng, Z. Huang, Y. Lin, Q. Shen, et al. 2019. Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling. mBio 10 (3): e00919-19.

Ma, Z., and B. Damania. 2016. The cGAS-STING Defense Pathway and Its Counteraction by Viruses. Cell Host & Microbe 19 (2): 150–158.

Article  CAS  Google Scholar 

Wang, J., S. Yang, L. Liu, H. Wang, and B. Yang. 2017. HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity. Virus Research 232: 13–21.

Article  CAS  PubMed  Google Scholar 

Li, Y., H. Wu, W. Wu, W. Zhuo, W.X. Liu, et al. 2014. Structural insights into the TRIM family of ubiquitin E3 ligases. Cell Research. 24 (6): 762–765.