Abbasi R, Nejati V, Rezaie J (2024) Exosomes biogenesis was increased in metformin-treated human ovary cancer cells; possibly to mediate resistance. Cancer Cell Int 24(1):137. https://doi.org/10.1186/s12935-024-03312-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adzhubei I, Jordan DM, Sunyaev SR (2013) Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protocol Hum Gen 76(1):7–20. https://doi.org/10.1002/0471142905.hg0720s76

Article  Google Scholar 

Ajam-Hosseini M, Akhoondi F, Doroudian M (2023) Nano basedoncolytic viruses for cancer therapy. Crit Rev Oncol Hematol 185:103980. https://doi.org/10.1016/j.critrevonc.2023.103980

Almohammai A, Rahbarghazi R, Keyhanmanesh R, Rezaie J, Ahmadi M (2021) Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues. J Inflamm 18:1–9. https://doi.org/10.1186/s12950-021-00275-7

Article  CAS  Google Scholar 

Altıntaş O, Saylan Y (2023) Exploring the versatility of exosomes: a review on isolation, characterization, detection methods, and diverse applications. Anal Chem 95(44):16029–16048. https://doi.org/10.1021/acs.analchem.3c02224

Anzalone AV, Koblan LW, Liu DR (2020) Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors. Nat Biotech 38(7):824–844. https://doi.org/10.1038/s41587-020-0561-9

Article  CAS  Google Scholar 

Azhdari MH, Goodarzi N, Doroudian M, MacLoughlin R (2022) Molecular insight into the therapeutic effects of stem cell-derived exosomes in respiratory diseases and the potential for pulmonary delivery. Int J Molec Sci 23(11):6273. https://doi.org/10.3390/ijms23116273

Article  CAS  Google Scholar 

Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, Szabo G (2011) Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor α (TNFα) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem 286(2):1436–1444. https://doi.org/10.1074/jbc.M110.145870

Article  CAS  PubMed  Google Scholar 

Barrangou R, Fremaux C, Deveau H, Richards M, Boyaval P, Moineau S, Romero DA, Horvath P (2007) CRISPR provides acquired resistance against viruses in prokaryotes. Science 315(5819):1709–1712. https://doi.org/10.1126/science.1138140

Article  CAS  PubMed  Google Scholar 

Batrakova EV, Kim MS (2015) Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Rel 219:396–405. https://doi.org/10.1016/j.jconrel.2015.07.030

Article  CAS  Google Scholar 

Berezhna SY, Supekova L, Sever MJ, Schultz PG, Deniz AA (2011) Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies. Rna 17(10):1831–1845. https://doi.org/10.1261/rna.2523911

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calabrese R, Capriotti E, Fariselli P, Martelli PL, Casadio R (2009) Functional annotations improve the predictive score of human disease-related mutations in proteins. Hum Mutat 30(8):1237–1244. https://doi.org/10.1002/humu.21047

Article  CAS  PubMed  Google Scholar 

Carugo O, Pongor S (2001) A normalized root-mean-spuare distance for comparing protein three-dimensional structures. Protein Sci 10(7):1470–1473. https://doi.org/10.1110/ps.690101

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cecchin R, Troyer Z, Witwer K, Morris KV (2023) Extracellular vesicles: The next generation in gene therapy delivery. Molec Ther 31(5):1–6. https://doi.org/10.1016/j.ymthe.2023.01.021

Article  CAS  Google Scholar 

Chen Q, Shen Y, Zheng J (2021) A review of cystic fibrosis: Basic and clinical aspects. Anim Models Exp Med 4(3):220–232. https://doi.org/10.1002/ame2.12180

Article  Google Scholar 

Chen Z, Xiong M, Tian J, Song D, Duan S, Zhang L (2024) Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review. J Nanobiotechnol 22(1):1–19. https://doi.org/10.1186/s12951-023-02259-6

Article  Google Scholar 

Dinh PUC, Paudel D, Brochu H, Popowski KD, Gracieux MC, Cores J, Huang K, Hensley MT, Harrell E, Vandergriff AC, George AK (2020) Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. Nat Mommun 11(1):1064. https://doi.org/10.1038/s41467-020-14344-7

Article  CAS  Google Scholar 

Dong B, Wang C, Zhang J, Zhang J, Gu Y, Guo X, Zuo X, Pan H, Hsu ACY, Wang G, Wang F (2021) Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization. Stem Cell Res Ther 12:1–17. https://doi.org/10.1186/s13287-021-02244-6

Article  CAS  Google Scholar 

Doroudian M, Zanganeh S, Abbasgholinejad E, Donnelly SC (2023a) Nanomedicine in lung cancer immunotherapy. Front Bioeng Biotechnol 11:1144653. https://doi.org/10.3389/fbioe.2023.1144653

Article  PubMed  PubMed Central  Google Scholar 

Doroudian M, Armstrong ME, Donnelly SC (2023b) Nano-based therapies for acute and chronic lung diseases. In: Biotechnology applied to inflammatory diseases: Cellular mechanisms and nanomedicine, pp 271–286. https://doi.org/10.1007/978-981-19-8342-9_12

Doyle LM, Wang MZ (2019) Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells 8(7):727. https://doi.org/10.3390/cells8070727

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eltoukhy AA, Chen D, Veiseh O, Pelet JM, Yin H, Dong Y, Anderson DG (2014) Nucleic acid-mediated intracellular protein delivery by lipid-like nanoparticles. Biomaterials 35(24):6454–6461. https://doi.org/10.1016/j.biomaterials.2014.04.014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eulalio A, Behm-Ansmant I, Schweizer D, Izaurralde E (2007) P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Molec Cell Biol 27(11):3970–3981. https://doi.org/10.1128/MCB.00128-07

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Z-S, Zhang C-J, Xia N, Tian H, Li D-Y, Lin J-Q, Xi-Fan Mei CW (2021) Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy. Acta Biomater 126:211–23. https://doi.org/10.1016/j.actbio.2021.03.018

Article  CAS  PubMed  Google Scholar 

Gee P, Lung MS, Okuzaki Y, Sasakawa N, Iguchi T, Makita Y, Hozumi H, Miura Y, Yang LF, Iwasaki M, Wang XH (2020) Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping. Nat Commun 11(1):1334. https://doi.org/10.1038/s41467-020-14957-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghasempour E, Hesami S, Movahed E, Keshel SH, Doroudian M (2022) Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors. Stem Cell Res Ther 13(1):527. https://doi.org/10.1186/s13287-022-03212-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Givens BE, Naguib YW, Geary SM, Devor EJ, Salem AK (2018) Nanoparticle-based delivery of CRISPR/Cas9 genome-editing therapeutics. AAPS J 20:1–22. https://doi.org/10.1208/s12248-018-0267-9

Article  CAS  Google Scholar 

Gonçalves GAR, de Paiva R, M. A. (2017) Gene therapy: advances, challenges and perspectives. Einstein 15(3):369–375. https://doi.org/10.1590/S1679-45082017RB4024

Article  PubMed  PubMed Central  Google Scholar 

Gong C, Tian J, Wang Z, Gao Y, Wu X, Ding X, Qiang L, Li G, Han Z, Yuan Y, Gao S (2019) Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy. J Nanobiotechnol 17:1–18. https://doi.org/10.1186/s12951-019-0526-7

Article  CAS  Google Scholar 

Gori JL, Hsu PD, Maeder ML, Shen S, Welstead GG, Bumcrot D (2015) Delivery and specificity of CRISPR/Cas9 genome editing technologies for human gene therapy. Hum Gene Ther 26(7):443–51. https://doi.org/10.1089/hum.2015.074

Article  CAS  PubMed  Google Scholar 

Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Groβ M, Hofmann N, Geffers R, Skawran B (2014) Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. Hepatology 59(5):1900–1911. https://doi.org/10.1002/hep.26997