A novel antitumor mechanism of triptonide in colorectal cancer: inducing ferroptosis via the SLC7A11/GPX4 axis

Baidoun F, Elshiwy K, Elkeraie Y, Merjaneh Z, Khoudari G, Sarmini MT, Gad M, Al-Husseini M, Saad A (2021) Colorectal Cancer epidemiology: recent trends and Impact on outcomes. Curr Drug Targets 22:998–1009. https://doi.org/10.2174/1389450121999201117115717

Article  CAS  PubMed  Google Scholar 

Chang Z, Qin W, Zheng H, Schegg K, Han L, Liu X, Wang Y, Wang Z (2021) Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates. Nat Commun 12:1253. https://doi.org/10.1038/s41467-021-21517-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Li J, Kang R, Klionsky DJ, Tang D (2021) Ferroptosis: machinery and regulation. Autophagy 17:2054–2081. https://doi.org/10.1080/15548627.2020.1810918

Article  CAS  PubMed  Google Scholar 

Chen H, Qi Q, Wu N, Wang Y, Feng Q, Jin R, Jiang L (2022) Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer. Redox Biol 55:102426. https://doi.org/10.1016/j.redox.2022.102426

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng Q, Chen M, Liu M, Chen X, Zhu L, Xu J, Xue J, Wu H, Du Y (2022) Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis. Cell Death Dis 13:608. https://doi.org/10.1038/s41419-022-05065-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chinison J, Aguilar JS, Avalos A, Huang Y, Wang Z, Cameron DJ, Hao J (2016) Triptonide effectively inhibits Wnt/beta-Catenin signaling via C-terminal transactivation domain of beta-catenin. Sci Rep 6:32779. https://doi.org/10.1038/srep32779

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong F, Yang P, Wang R, Sun W, Zhang Y, Wang A, Chen M, Chen L, Zhang C, Jiang M (2019) Triptonide acts as a novel antiprostate cancer agent mainly through inhibition of mTOR signaling pathway. Prostate 79:1284–1293. https://doi.org/10.1002/pros.23834

Article  CAS  PubMed  Google Scholar 

Fan A, Wang B, Wang X, Nie Y, Fan D, Zhao X, Lu Y (2021) Immunotherapy in colorectal cancer: current achievements and future perspective. Int J Biol Sci 17:3837–3849. https://doi.org/10.7150/ijbs.64077

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu L, Niu X, Jin R, Xu F, Ding J, Zhang L, Huang Z (2020) Triptonide inhibits metastasis potential of thyroid cancer cells via astrocyte elevated gene-1. Translational cancer Res 9:1195–1204. https://doi.org/10.21037/tcr.2019.12.94

Article  CAS  Google Scholar 

Gao B, Chen J, Han B, Zhang X, Hao J, Giuliano AE, Cui Y, Cui X (2021) Identification of triptonide as a therapeutic agent for triple negative breast cancer treatment. Sci Rep 11:2408. https://doi.org/10.1038/s41598-021-82128-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang W, Chen K, Lu Y, Zhang D, Cheng Y, Li L, Huang W, He G, Liao H, Cai L, Tang Y, Zhao L, Pan M (2021) ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. Neoplasia 23:1227–1239. https://doi.org/10.1016/j.neo.2021.11.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22:266–282. https://doi.org/10.1038/s41580-020-00324-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Q, Peng F, Yan X, Chen Y, Zhou J, Wu S, Jiang W, Jin X, Liang J, Peng C, Pan X (2023) Inhibition of SLC7A11-GPX4 signal pathway is involved in aconitine-induced ferroptosis in vivo and in vitro. J Ethnopharmacol 303:116029. https://doi.org/10.1016/j.jep.2022.116029

Article  CAS  PubMed  Google Scholar 

Liu L, Yang S, Wang H (2021) Alpha-lipoic acid alleviates ferroptosis in the MPP(+) -induced PC12 cells via activating the PI3K/Akt/Nrf2 pathway. Cell Biol Int 45:422–431. https://doi.org/10.1002/cbin.11505

Article  CAS  PubMed  Google Scholar 

Liu XY, Wei DG, Li RS (2022a) Capsaicin induces ferroptosis of NSCLC by regulating SLC7A11/GPX4 signaling in vitro. Sci Rep 12:11996. https://doi.org/10.1038/s41598-022-16372-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Chen C, Han D, Zhou W, Cui Y, Tang X, Xiao C, Wang Y, Gao Y (2022b) SLC7A11/GPX4 inactivation-mediated ferroptosis contributes to the pathogenesis of Triptolide-Induced Cardiotoxicity. Oxid Med Cell Longev 2022(3192607). https://doi.org/10.1155/2022/3192607

Liu H, Zhang TA, Zhang WY, Huang SR, Hu Y, Sun J (2023) Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway. Exp Neurol 369:114541. https://doi.org/10.1016/j.expneurol.2023.114541

Article  CAS  PubMed  Google Scholar 

Mo X, Hu D, Yuan K, Luo J, Huang C, Xu M (2023) Tetrandrine citrate suppresses lung adenocarcinoma growth via SLC7A11/GPX4-mediated ferroptosis. Discov Oncol 14:85. https://doi.org/10.1007/s12672-023-00691-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piawah S, Venook AP (2019) Targeted therapy for colorectal cancer metastases: a review of current methods of molecularly targeted therapy and the use of tumor biomarkers in the treatment of metastatic colorectal cancer. Cancer 125:4139–4147. https://doi.org/10.1002/cncr.32163

Article  PubMed  Google Scholar 

Shin AE, Giancotti FG, Rustgi AK (2023) Metastatic colorectal cancer: mechanisms and emerging therapeutics. Trends Pharmacol Sci 44:222–236. https://doi.org/10.1016/j.tips.2023.01.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun S, Guo C, Gao T, Ma D, Su X, Pang Q, Zhang R (2022) Hypoxia enhances Glioma Resistance to Sulfasalazine-Induced ferroptosis by upregulating SLC7A11 via PI3K/AKT/HIF-1alpha Axis. Oxid Med Cell Longev 2022(7862430). https://doi.org/10.1155/2022/7862430

Thanikachalam K, Khan G (2019) Colorectal Cancer and Nutrition. Nutrients 11. https://doi.org/10.3390/nu11010164

Wang Y, Zhang Z, Sun W, Zhang J, Xu Q, Zhou X, Mao L (2022a) Ferroptosis in colorectal cancer: potential mechanisms and effective therapeutic targets. Biomed Pharmacother 153:113524. https://doi.org/10.1016/j.biopha.2022.113524

Article  CAS  PubMed  Google Scholar 

Wang Y, Shen Z, Zhao S, Huang D, Wang X, Wu Y, Pei C, Shi S, Jia N, He Y, Wang Z (2022b) Sipeimine ameliorates PM2.5-induced lung injury by inhibiting ferroptosis via the PI3K/Akt/Nrf2 pathway: a network pharmacology approach. Ecotoxicol Environ Saf 239:113615. https://doi.org/10.1016/j.ecoenv.2022.113615

Article  CAS  PubMed  Google Scholar 

Wei R, Zhao Y, Wang J, Yang X, Li S, Wang Y, Yang X, Fei J, Hao X, Zhao Y, Gui L, Ding X (2021) Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. Int J Biol Sci 17:2703–2717. https://doi.org/10.7150/ijbs.59404

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan H, Talty R, Aladelokun O, Bosenberg M, Johnson CH (2023a) Ferroptosis in colorectal cancer: a future target? Br J Cancer 128:1439–1451. https://doi.org/10.1038/s41416-023-02149-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan H, Talty R, Johnson CH (2023b) Targeting ferroptosis to treat colorectal cancer. Trends Cell Biol 33:185–188. https://doi.org/10.1016/j.tcb.2022.11.003

Article  CAS  PubMed  Google Scholar 

Yang A, Qin S, Schulte BA, Ethier SP, Tew KD, Wang GY (2017) MYC inhibition depletes Cancer stem-like cells in Triple-negative breast Cancer. Cancer Res 77:6641–6650. https://doi.org/10.1158/0008-5472.CAN-16-3452

Article  CAS 

留言 (0)

沒有登入
gif