Lee WM (2013) Drug-induced acute liver failure. Clin Liver Dis 17(4):575–586 viii

Article  PubMed  Google Scholar 

Bunchorntavakul C, Reddy KR (2018) Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and Acute Liver failure. Clin Liver Dis 22(2):325–346

Article  PubMed  Google Scholar 

Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez FJ (1996) Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271(20):12063–12067

Article  PubMed  CAS  Google Scholar 

Chen C, Krausz KW, Idle JR, Gonzalez FJ (2008) Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. J Biol Chem 283(8):4543–4559

Article  PubMed  CAS  Google Scholar 

Roberts DW, Pumford NR, Potter DW, Benson RW, Hinson JA (1987) A sensitive immunochemical assay for acetaminophen-protein adducts. J Pharmacol Exp Ther 241(2):527–533

PubMed  CAS  Google Scholar 

Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA (2006) Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 131(1):165–178

Article  PubMed  CAS  Google Scholar 

Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A et al (2013) CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. J Hepatol 59(3):495–503

Article  PubMed  CAS  Google Scholar 

Zhang J, Guo J, Yang N, Huang Y, Hu T, Rao C (2022) Endoplasmic reticulum stress-mediated cell death in liver injury. Cell Death Dis. ;13(12)

Wang X, Thomas B, Sachdeva R, Arterburn L, Frye L, Hatcher PG et al (2006) Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress. Proc Natl Acad Sci U S A 103(10):3604–3609

Article  PubMed  PubMed Central  CAS  Google Scholar 

Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC et al (2012) A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. Embo j 31(6):1364–1378

Article  PubMed  PubMed Central  Google Scholar 

Purcell RH, Hall RA (2018) Adhesion G protein-coupled receptors as drug targets. Annu Rev Pharmacol Toxicol 58:429–449

Article  PubMed  CAS  Google Scholar 

Olaniru OE, Persaud SJ (2019) Adhesion G-protein coupled receptors: implications for metabolic function. Pharmacol Ther 198:123–134

Article  PubMed  CAS  Google Scholar 

Zheng T, Sun M, Liu L, Lan Y, Wang L, Lin F (2021) GPR116 overexpression correlates with poor prognosis in gastric cancer. Medicine 100(48):e28059

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tang X, Jin R, Qu G, Wang X, Li Z, Yuan Z et al (2013) GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Galphaq-p63RhoGEF-Rho GTPase pathway. Cancer Res 73(20):6206–6218

Article  PubMed  CAS  Google Scholar 

Wang C, Fan H, Zhang Y (2019) MiR-511-5p functions as a tumor suppressor and a predictive of prognosis in colorectal cancer by directly targeting GPR116. Eur Rev Med Pharmacol Sci 23(14):6119–6130

PubMed  CAS  Google Scholar 

Muthiah I, Rajendran K, Dhanaraj P (2021) In silico molecular docking and physicochemical property studies on effective phytochemicals targeting GPR116 for breast cancer treatment. Mol Cell Biochem 476(2):883–896

Article  PubMed  CAS  Google Scholar 

Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T et al (2013) Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D. PLoS ONE 8(7):e69451

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ariestanti DM, Ando H, Hirose S, Nakamura N (2015) Targeted disruption of Ig-Hepta/Gpr116 causes Emphysema-like symptoms that are Associated with alveolar macrophage activation. J Biol Chem 290(17):11032–11040

Article  PubMed  PubMed Central  CAS  Google Scholar 

Niaudet C, Petkova M, Jung B, Lu S, Laviña B, Offermanns S et al (2019) Adgrf5 contributes to patterning of the endothelial deep layer in retina. Angiogenesis 22(4):491–505

Article  PubMed  PubMed Central  CAS  Google Scholar 

Niaudet C, Hofmann J, Mäe M, Jung B, Gaengel K, Vanlandewijck M et al (2015) Gpr116 receptor regulates distinctive functions in Pneumocytes and Vascular Endothelium. PLoS ONE 10(9):e0137949

Article  PubMed  PubMed Central  Google Scholar 

Zaidman NA, Tomilin VN, Hassanzadeh Khayyat N, Damarla M, Tidmore J, Capen DE et al (2020) Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion. Proc Natl Acad Sci U S A 117(42):26470–26481

Article  PubMed  PubMed Central  CAS  Google Scholar 

Georgiadi A, Lopez-Salazar V, Merahbi RE, Karikari RA, Ma X, Mourão A et al (2021) Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Nat Commun 12(1):2999

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang Y, Wang T, Xiang Q, Li N, Wang J, Liu J et al (2023) GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc–/GSH/GPX4. Cell Biol Toxicol 39(6):3015–3030

Article  PubMed  CAS  Google Scholar 

Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX et al (2019) p53 Up-regulated modulator of apoptosis induction mediates Acetaminophen-Induced Necrosis and Liver Injury in mice. Hepatology 69(5):2164–2179

Article  PubMed  CAS  Google Scholar 

Torres S, Baulies A, Insausti-Urkia N, Alarcon-Vila C, Fucho R, Solsona-Vilarrasa E et al (2019) Endoplasmic reticulum stress-Induced Upregulation of STARD1 promotes Acetaminophen-Induced Acute Liver failure. Gastroenterology 157(2):552–568

Article  PubMed  CAS  Google Scholar 

Wang LX, Zhu XM, Luo YN, Wu Y, Dong N, Tong YL et al (2020) Sestrin2 protects dendritic cells against endoplasmic reticulum stress-related apoptosis induced by high mobility group box-1 protein. Cell Death Dis 11(2):125

Article  PubMed  PubMed Central  CAS  Google Scholar 

Severgnini M, Sherman J, Sehgal A, Jayaprakash NK, Aubin J, Wang G et al (2012) A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development. Cytotechnology 64(2):187–195

Article  PubMed  CAS  Google Scholar 

Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ (2009) Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance Acetaminophen-Induced toxicity. Drug Metab Dispos 37(8):1611–1621

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sénéchal C, Fujita R, Jamet S, Maiga A, Dort J, Orfi Z et al (2022) The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool. Cell Rep 41(7):111645

Article  PubMed  Google Scholar 

Tan S, Li L, Chen T, Chen X, Tao L, Lin X et al (2015) β-Arrestin-1 protects against endoplasmic reticulum stress/p53-upregulated modulator of apoptosis-mediated apoptosis via repressing p-p65/inducible nitric oxide synthase in portal hypertensive gastropathy. Free Radic Biol Med 87:69–83

Article  PubMed  CAS