Alizadeh A, Dyck SM, Karimi-Abdolrezaee S. Myelin damage and repair in pathologic CNS: challenges and prospects. Front Mol Neurosci. 2015;8:35.
Article PubMed PubMed Central Google Scholar
Lassmann H, van Horssen J, Mahad D. Progressive multiple sclerosis: pathology and pathogenesis. Nat Rev Neurol. 2012;8(11):647–56.
Article CAS PubMed Google Scholar
Yao F, Luo Y, Chen Y, Li Y, Hu X, You X, Li Z, Yu S, Tian D, Zheng M, et al. Myelin debris impairs tight junctions and promotes the Migration of Microvascular endothelial cells in the injured spinal cord. Cell Mol Neurobiol. 2023;43(2):741–56.
Article CAS PubMed Google Scholar
Olah M, Amor S, Brouwer N, Vinet J, Eggen B, Biber K, Boddeke HW. Identification of a microglia phenotype supportive of remyelination. GLIA. 2012;60(2):306–21.
Bogie J, Grajchen E, Wouters E, Corrales AG, Dierckx T, Vanherle S, Mailleux J, Gervois P, Wolfs E, Dehairs J et al. Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain. J Exp Med 2020, 217(5).
Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, et al. Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Nat Neurosci. 2020;23(2):194–208.
Article CAS PubMed PubMed Central Google Scholar
Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, van Wijngaarden P, Wagers AJ, Williams A, Franklin R, et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci. 2013;16(9):1211–8.
Article CAS PubMed PubMed Central Google Scholar
Olzmann JA, Carvalho P. Dynamics and functions of lipid droplets. Nat Rev Mol Cell Bio. 2019;20(3):137–55.
Loving BA, Tang M, Neal MC, Gorkhali S, Murphy R, Eckel RH, Bruce KD. Lipoprotein lipase regulates microglial lipid droplet accumulation. Cells Basel. 2021;10(2).
Xu Y, Propson NE, Du S, Xiong W, Zheng H. Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading. P Natl Acad Sci USA. 2021;118(27).
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ. Autophagy regulates lipid metabolism. Nature. 2009;458(7242):1131–5.
Article CAS PubMed PubMed Central Google Scholar
Chung J, Park J, Lai ZW, Lambert TJ, Richards RC, Zhang J, Walther TC, Farese RJ. The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. Nat Cell Biol. 2023;25(8):1101–10.
Article CAS PubMed PubMed Central Google Scholar
Laval T, Ouimet M. A role for lipophagy in atherosclerosis. Nat Rev Cardiol. 2023;20(7):431–2.
Article CAS PubMed Google Scholar
Pu M, Zheng W, Zhang H, Wan W, Peng C, Chen X, Liu X, Xu Z, Zhou T, Sun Q, et al. ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover. Protein Cell. 2023;14(9):653–67.
Wang Z, Zhang H. Join the club: ORP8 is a lipophagy receptor. Protein Cell. 2023;14(9):632–4.
Article PubMed PubMed Central Google Scholar
Haidar M, Loix M, Vanherle S, Dierckx T, Vangansewinkel T, Gervois P, Wolfs E, Lambrichts I, Bogie J, Hendriks J. Targeting lipophagy in macrophages improves repair in multiple sclerosis. Autophagy. 2022;18(11):2697–710.
Article CAS PubMed PubMed Central Google Scholar
Jeffries J, Zhou W, Hsu AY, Deng Q. miRNA-223 at the crossroads of inflammation and cancer. Cancer Lett. 2019;451:136–41.
Article CAS PubMed PubMed Central Google Scholar
Hobert O. Gene regulation by transcription factors and microRNAs. Science. 2008;319(5871):1785–6.
Article CAS PubMed Google Scholar
Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009;11(3):228–34.
Article CAS PubMed Google Scholar
Yang Y, Liang C. MicroRNAs: an emerging player in autophagy. ScienceOpen Res. 2015;2015.
Macfarlane LA, Murphy PR. MicroRNA: Biogenesis, function and role in Cancer. Curr Genomics 2010;11(7):537–61.
Article CAS PubMed PubMed Central Google Scholar
Lee DH, Park SH, Ahn J, Hong SP, Lee E, Jang YJ, Ha TY, Huh YH, Ha SY, Jeon TI, et al. Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis. Autophagy. 2021;17(9):2415–31.
Article CAS PubMed Google Scholar
Shao W, Wang S, Wang X, Yao L, Yuan X, Huang D, Lv B, Ye Y, Xue H. miRNA-29a inhibits atherosclerotic plaque formation by mediating macrophage autophagy via PI3K/AKT/mTOR pathway. Aging. 2022;14(5):2418–31.
Article CAS PubMed PubMed Central Google Scholar
Ma J, Yang S, Ma A, Pan X, Wang H, Li N, Liu S, Wu M. Expression of miRNA-155 in carotid atherosclerotic plaques of apolipoprotein E knockout (ApoE(-/-)) mice and the interventional effect of rapamycin. Int Immunopharmacol. 2017;46:70–4.
Zhou LQ, Dong MH, Hu ZW, Tang Y, Chu YH, Chen M, Yang S, Chen Z, Wu LJ, Wang W, et al. Staged suppression of microglial autophagy facilitates regeneration in CNS demyelination by enhancing the production of linoleic acid. P Natl Acad Sci USA. 2023;120(1):e2084977176.
Devanney NA, Stewart AN, Gensel JC. Microglia and macrophage metabolism in CNS injury and disease: the role of immunometabolism in neurodegeneration and neurotrauma. Exp Neurol. 2020;329:113310.
Article CAS PubMed PubMed Central Google Scholar
Sen MK, Mahns DA, Coorssen JR, Shortland PJ. The roles of microglia and astrocytes in phagocytosis and myelination: insights from the cuprizone model of multiple sclerosis. GLIA. 2022;70(7):1215–50.
Article CAS PubMed PubMed Central Google Scholar
Bogie JF, Timmermans S, Huynh-Thu VA, Irrthum A, Smeets HJ, Gustafsson JÅ, Steffensen KR, Mulder M, Stinissen P, Hellings N, et al. Myelin-derived lipids modulate macrophage activity by liver X receptor activation. PLoS One. 2012;7(9):e44998.
Article CAS PubMed PubMed Central Google Scholar
Bogie JF, Jorissen W, Mailleux J, Nijland PG, Zelcer N, Vanmierlo T, Van Horssen J, Stinissen P, Hellings N, Hendriks JJ. Myelin alters the inflammatory phenotype of macrophages by activating PPARs. Acta Neuropathol Com. 2013;1:43.
Bogie JF, Stinissen P, Hellings N, Hendriks JJ. Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation. J Neuroinflamm. 2011;8:85.
Zhuang W, Zhang L, Zheng Y, Liu B, Ma C, Zhao W, Liu S, Liu F, Gao C. USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation. Cell Mol Immunol. 2022;19(10):1141–52.
Article CAS PubMed PubMed Central Google Scholar
Festa BP, Siddiqi FH, Jimenez-Sanchez M, Rubinsztein DC. Microglial cytokines poison neuronal autophagy via CCR5, a druggable target. Autophagy 2023:1–3.
Houtman J, Freitag K, Gimber N, Schmoranzer J, Heppner FL, Jendrach M. Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3. EMBO J. 2019;38(4).
Yang L, Gao X, Tian D, Yang W, Xue S, Cao Z, Sun T. Resolvin D2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats. Exp Neurol. 2023;370:114573.
Article CAS PubMed Google Scholar
Amin S, Liu B, Gan L. Autophagy prevents microglial senescence. Nat Cell Biol. 2023;25(7):923–5.
留言 (0)