Martin SS, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, et al. 2024 Heart Disease and Stroke statistics: a report of US and Global Data from the American Heart Association. Circulation. 2024;149(8):e347–913.

Article  Google Scholar 

Libby P. The changing landscape of atherosclerosis. Nature. 2021;592(7855):524–33.

Article  CAS  Google Scholar 

Li H, Cao Z, Wang L, Liu C, Lin H, Tang Y, Yao P. Macrophage subsets and death are responsible for atherosclerotic plaque formation. Front Immunol. 2022;13:843712.

Article  CAS  Google Scholar 

Hou P, Fang J, Liu Z, Shi Y, Agostini M, Bernassola F, Bove P, Candi E, Rovella V, Sica G, et al. Macrophage polarization and metabolism in atherosclerosis. Cell Death Dis. 2023;14(10):691.

Article  Google Scholar 

Oumouna-Benachour K, Hans CP, Suzuki Y, Naura A, Datta R, Belmadani S, et al. Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappab nuclear translocation, and foam cell death. Circulation. 2007;115(18):2442–50.

Article  CAS  Google Scholar 

Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature. 2007;446(7138):916–20.

Article  CAS  Google Scholar 

Hatakeyama S. TRIM family proteins: roles in Autophagy, immunity, and Carcinogenesis. Trends Biochem Sci. 2017;42(4):297–311.

Article  CAS  Google Scholar 

Rajsbaum R, García-Sastre A, Versteeg GA. TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J Mol Biol. 2014;426(6):1265–84.

Article  CAS  Google Scholar 

Liu S, Bi H, Jiang M, Chen Y. An update on the role of TRIM/NLRP3 signaling pathway in atherosclerosis. Biomed Pharmacother. 2023;160:114321.

Article  CAS  Google Scholar 

Nagre N, Cong X, Terrazas C, Pepper I, Schreiber JM, Fu H, et al. Inhibition of macrophage complement receptor CRIg by TRIM72 polarizes innate immunity of the lung. Am J Respir Cell Mol Biol. 2018;58(6):756–66.

Article  CAS  Google Scholar 

Liu Z, Wu C, Pan Y, Liu H, Wang X, Yang Y, Gu M, Zhang Y. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Sci Adv. 2019;5(2):eaav0163.

Article  CAS  Google Scholar 

Lu M, Zhu X, Yang Z, Zhang W, Sun Z, Ji Q, Chen X, Zhu J, Wang C, Nie S. E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages. Mol Immunol. 2019;109:126–33.

Article  CAS  Google Scholar 

Li Z, Liu X, Zhang X, Zhang W, Gong M, Qin X, Luo J, Fang Y, Liu B, Wei Y. TRIM21 aggravates cardiac injury after myocardial infarction by promoting M1 macrophage polarization. Front Immunol. 2022;13:1053171.

Article  CAS  Google Scholar 

Lin H, Jiang M, Liu L, Yang Z, Ma Z, Liu S, et al. The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response. Nat Immunol. 2019;20(7):812–23.

Article  CAS  Google Scholar 

Sun D, Li S, Chen S, Zhang S, Gu Q, Shen Y, Wei F, Wang N. TRIM25 inhibition attenuates inflammation, senescence, and oxidative stress in microvascular endothelial cells induced by hyperglycemia. Graefes Arch Clin Exp Ophthalmol. 2023;262(1):81–91.

Article  Google Scholar 

Gong B, Wang Z, Zhang M, Hu Z, Ren Z, Tang Z, et al. Disturbed P53-MDM2 feedback Loop contributes to thoracic aortic dissection formation and may be a result of TRIM25 overexpression. Ann Vasc Surg. 2017;40:243–51.

Article  Google Scholar 

D’Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B, Serrels A, Parsons M et al. ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning. Development. 2022; 149(13).

Yang J, Zhao Y, Zhang L, Fan H, Qi C, Zhang K, et al. RIPK3/MLKL-Mediated neuronal necroptosis modulates the M1/M2 polarization of Microglia/Macrophages in the ischemic cortex. Cereb Cortex. 2018;28(7):2622–35. https://doi.org/10.1093/cercor/bhy089.

Article  Google Scholar 

Jiao Y, Zhang T, Zhang C, Ji H, Tong X, Xia R, et al. Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. Crit Care. 2021;25(1):356. https://doi.org/10.1186/s13054-021-03775-3.

Article  Google Scholar 

Li N, Chen J, Geng C, Wang X, Wang Y, Sun N, et al. Myoglobin promotes macrophage polarization to M1 type and pyroptosis via the RIG-I/Caspase1/GSDMD signaling pathway in CS-AKI. Cell Death Discov. 2022;8(1):90. https://doi.org/10.1038/s41420-022-00894-w.

Article  CAS  Google Scholar 

Wang L, Wang D, Sonzogni O, Ke S, Wang Q, Thavamani A, Batalini F, Stopka SA, Regan MS, Vandal S, et al. PARP-inhibition reprograms macrophages toward an anti-tumor phenotype. Cell Rep. 2022;41(2):111462.

Article  CAS  Google Scholar 

Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, et al. Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. Nat cancer. 2021;2(1):66–82.

Article  CAS  Google Scholar 

Inoue S, Orimo A, Hosoi T, Kondo S, Toyoshima H, Kondo T, et al. Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. Proc Natl Acad Sci U S A. 1993;90(23):11117–21.

Article  CAS  Google Scholar 

Chen JJ, Ren YL, Shu CJ, Zhang Y, Chen MJ, Xu J, et al. JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis. Exp Clin Cancer Res. 2020;39(1):118.

Article  Google Scholar 

Xie Z, Wu XJ, Cheng RW, Cui JH, Yuan ST, Zhou JW, et al. JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice. Acta Pharmacol Sin. 2023;44(4):897–912.

Article  CAS  Google Scholar 

Soldani C, Scovassi AI, Canosi U, Bramucci E, Ardissino D, Arbustini E. Multicolor fluorescence technique to detect apoptotic cells in advanced coronary atherosclerotic plaques. Eur J Histochem. 2005;49(1):47–52.

Article  CAS  Google Scholar 

Tian F, Yao J, Yan M, Sun X, Wang W, Gao W, et al. 5-Aminolevulinic acid-mediated Sonodynamic Therapy inhibits RIPK1/RIPK3-Dependent necroptosis in THP-1-Derived foam cells. Sc Rep. 2016;6:21992.

Article  CAS  Google Scholar 

Colijn S, Muthukumar V, Xie J, Gao S, Griffin CT. Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis. Dis Models Mech. 2020;13(1):dmm041962.

Article  CAS  Google Scholar 

Rasheed A, Robichaud S, Nguyen MA, Geoffrion M, Wyatt H, Cottee ML, et al. Loss of MLKL (mixed lineage kinase Domain-Like protein) decreases necrotic core but increases macrophage lipid Accumulation in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2020;40(5):1155–67.

Article  CAS  Google Scholar 

Adamowicz M, Hailstone R, Demin AA, Komulainen E, Hanzlikova H, Brazina J, et al. XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nat Cell Biol. 2021;23(12):1287–98.

Article  CAS  Google Scholar 

Xu S, Bai P, Little PJ, Liu P. Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications. Med Res Rev. 2014;34(3):644–75.

Article  CAS  Google Scholar 

Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, et al. XRCC1 prevents toxic PARP1 trapping during DNA base excision repair. Mol Cell. 2021;81(14):3018–e303015.

Article  CAS  Google Scholar 

Reber JM, Božić-Petković J, Lippmann M, Mazzardo M, Dilger A, Warmers R, et al. PARP1 and XRCC1 exhibit a reciprocal relationship in genotoxic stress response. Cell Biol Toxicol. 2023;39(1):345–64.

Article  CAS  Google Scholar 

Shyu HY, Shieh JC, Ji-Ho L, Wang HW, Cheng CW. Polymorphisms of DNA repair pathway genes and cigarette smoking in relation to susceptibility to large artery atherosclerotic stroke among ethnic Chinese in Taiwan. J Atheroscler Thromb. 2012;19(4):316–25.

Article  CAS  Google Scholar 

Wang X, Lian Z, Ge Y, Yu D, Li S, Tan K. TRIM25 rescues against Doxorubicin-Induced pyroptosis through promoting NLRP1 ubiquitination. Cardiovasc Toxicol. 2021;21(10):859–68.

Article  CAS  Google Scholar 

Pietrzak J, Płoszaj T, Pułaski Ł, Robaszkiewicz A. EP300-HDAC1-SWI/SNF functional unit defines transcription of some DNA repair enzymes during differentiation of human macrophages. Biochim Biophys Acta Gene Regul Mech. 2019;1862(2):198–208.

Article  CAS  Google Scholar