Burisch J, Zhao M, Odes S, De Cruz P, Vermeire S, Bernstein CN, et al. The cost of inflammatory bowel disease in high-income settings: a Lancet Gastroenterology & Hepatology Commission. Lancet Gastroenterol Hepatol. 2023;8:458–92.
Khan R, Kuenzig ME, Benchimol EI. Epidemiology of pediatric inflammatory Bowel disease. Gastroenterol Clin. 2023;52:483–96.
Andoh A, Nishida A. Molecular basis of intestinal fibrosis in inflammatory Bowel disease. Inflamm Intest Dis. 2023;7:119–27.
Park JM, Kim J, Lee YJ, Bae SU, Lee HW. Inflammatory bowel disease-associated intestinal fibrosis. J Pathol Transl Med. 2023;57:60–6.
Article PubMed PubMed Central Google Scholar
Wang Y, Huang B, Jin T, Ocansey DKW, Jiang J, Mao F. Intestinal fibrosis in inflammatory Bowel disease and the prospects of mesenchymal stem cell therapy. Front Immunol. 2022;13:835005.
Article CAS PubMed PubMed Central Google Scholar
Solitano V, Dal Buono A, Gabbiadini R, Wozny M, Repici A, Spinelli A, et al. Fibro-stenosing Crohn’s Disease: what is new and what is next? J Clin Med. 2023;12:3052.
Article PubMed PubMed Central Google Scholar
Rimola J, Capozzi N. Differentiation of fibrotic and inflammatory component of Crohn’s disease-associated strictures. Intest Res. 2020;18:144–50.
Article PubMed PubMed Central Google Scholar
Yoo JH, Holubar S, Rieder F. Fibrostenotic structures in Crohn’s disease. Intest Res. 2020;18:379–401.
Article PubMed PubMed Central Google Scholar
Alfredsson J, Wick MJ. Mechanism of fibrosis and structure formation in Crohn’s disease. Scand J Immunol. 2020;92:e12990.
Article CAS PubMed PubMed Central Google Scholar
Tavares de Sousa H, Magro F. How to evaluate fibrosis in IBD? Diagnostics. 2023;13:2188.
Article CAS PubMed PubMed Central Google Scholar
Ippolito C, Colucci R, Segnani C, Errede M, Girolamo F, Virgintino D, et al. Fibrotic and vascular remodelling of colonic wall in patients with active ulcerative colitis. J Crohn’s Colitis. 2016;10:1194–204.
Magro F, Sousa HT. Editorial: ulcerative colitis submucosal fibrosis and inflammation: more than just strictures. Aliment Pharmacol Ther. 2018;47:1033–4.
Article CAS PubMed Google Scholar
Goulston SJ, McGovern VJ. The nature of benign strictures in ulcerative colitis. N Engl J Med. 1969;281:290–5.
Article CAS PubMed Google Scholar
de Bruyn JR, Meijer SL, Wildenberg ME, Bemelman WA, van den Brink GR, D’Haens GR. Development of fibrosis in acute and longstanding ulcerative colitis. J Crohns Colitis. 2015;9:966–72.
Wu X, Lin X, Tan J, Liu Z, He J, Hu F, et al. Cellular and molecular mechanisms of intestinal fibrosis. Gut Liver. 2023;17:360–74.
Article CAS PubMed PubMed Central Google Scholar
Hayashi Y, Nakase H. The molecular mechanisms of intestinal inflammation and fibrosis in Crohn’s Disease. Front Physiol. 2022;13:845078.
Article PubMed PubMed Central Google Scholar
Wang J, Lin S, Brown JM, van Wagoner D, Fiocchi C, Rieder F. Novel mechanisms and clinical trial endpoints in intestinal fibrosis. Immunol Rev. 2021;302:211–27.
Article CAS PubMed PubMed Central Google Scholar
Davidson S, Coles M, Thomas T, Kollias G, Ludewig B, Turley S, et al. Fibroblasts as immune regulators in infection, inflammation and cancer. Nat Rev Immunol. 2021;21:704–17.
Article CAS PubMed Google Scholar
Lenti MV, Santacroce G, Broglio G, Rossi CM, Di Sabatino A. Recent advances in intestinal fibrosis. Mol Aspects Med. 2024;96:101251.
Article CAS PubMed Google Scholar
Roeb E. Interleukin-13 (IL-13)—a pleiotropic cytokine involved in wound healing and fibrosis. Int J Mol Sci. 2023;24:12884.
Article CAS PubMed PubMed Central Google Scholar
Lee JH, Massagué J. TGF-β in developmental and fibrogenic EMTs. Semin Cancer Biol. 2022;86:136–45.
Article CAS PubMed PubMed Central Google Scholar
Lovisa S, Genovese G, Danese S. Role of epithelial-to-mesenchymal transition in inflammatory Bowel disease. J Crohns Colitis. 2019;13:659–68.
Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis*. J Biol Chem. 2010;285:20202–12.
Article CAS PubMed PubMed Central Google Scholar
Lin X, Wang Y, Liu Z, Lin S, Tan J, He J, et al. Intestinal strictures in Crohn’s disease: a 2021 update. Therap Adv Gastroenterol. 2022;15:17562848221104952.
Article PubMed PubMed Central Google Scholar
Lin S-N, Mao R, Qian C, Bettenworth D, Wang J, Li J, et al. Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases. Physiol Rev. 2022;102:605–52.
Article CAS PubMed Google Scholar
de Bruyn JR, Becker MA, Steenkamer J, Wildenberg ME, Meijer SL, Buskens CJ, et al. Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn’s disease. PLoS ONE. 2018;13:e0190999.
Article PubMed PubMed Central Google Scholar
Martin JC, Chang C, Boschetti G, Ungaro R, Giri M, Grout JA, et al. Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to Anti-TNF Therapy. Cell. 2019;178:1493-1508.e20.
Article CAS PubMed PubMed Central Google Scholar
Xiong S, Whitehurst CE, Li L, Heo GS, Lai C-W, Jain U, et al. Reverse translation approach generates a signature of penetrating fibrosis in Crohn’s disease that is associated with anti-TNF response. Gut. 2022;71:1289–301.
Article CAS PubMed Google Scholar
Hinz B. The myofibroblast: paradigm for a mechanically active cell. J Biomech. 2010;43:146–55.
Beaven E, Kumar R, Bhatt HN, Esquivel SV, Nurunnabi M. Myofibroblast specific targeting approaches to improve fibrosis treatment. Chem Commun (Camb). 2022;58:13556–71.
Article CAS PubMed Google Scholar
De Salvo C, Ray S, Pizarro TT. Mechanisms and models for intestinal fibrosis in IBD. Dig Dis. 2014;32:26–34.
Grassl GA, Valdez Y, Bergstrom KSB, Vallance BA, Finlay BB. Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis. Gastroenterology. 2008;134:768–80.
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