Betjes MG. Uremia-Associated Ageing of the Thymus and adaptive Immune responses. Toxins. 2020;12:224.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen G. Immune Dysfunction in Uremia 2020. Toxins. 2020;12:439.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cozzolino M, Mangano M, Stucchi A, Ciceri P, Conte F, Galassi A. Cardiovascular disease in dialysis patients. Nephrol Dial Transplant off Publ Eur Dial Transpl Assoc -. Eur Ren Assoc. 2018;33:iii28–34.

CAS  Google Scholar 

Rocchetti MT, Cosola C, Ranieri E, Gesualdo L. Protein-bound uremic toxins and immunity. Methods Mol Biol Clifton NJ. 2021;2325:215–27.

Article  CAS  Google Scholar 

Wu H, Dong J, Yu H, Wang K, Dai W, Zhang X, et al. Single-cell RNA and ATAC sequencing reveal hemodialysis-related Immune Dysregulation of circulating Immune Cell subpopulations. Front Immunol. 2022;13:878226.

Article  PubMed  PubMed Central  Google Scholar 

Losappio V, Franzin R, Infante B, Godeas G, Gesualdo L, Fersini A, et al. Molecular mechanisms of premature aging in Hemodialysis: the Complex interplay between Innate and Adaptive Immune Dysfunction. Int J Mol Sci. 2020;21:3422.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sampani E, Stangou M, Daikidou D-V, Nikolaidou V, Asouchidou D, Dimitriadis C, et al. Influence of end stage renal disease on CD28 expression and T-cell immunity. Nephrol Carlton Vic. 2021;26:185–96.

Article  CAS  Google Scholar 

Dedeoglu B, de Weerd AE, Huang L, Langerak AW, Dor FJ, Klepper M, et al. Lymph node and circulating T cell characteristics are strongly correlated in end-stage renal disease patients, but highly differentiated T cells reside within the circulation. Clin Exp Immunol. 2017;188:299–310.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiang F, Chen R, Cao X, Shen B, Chen X, Ding X, et al. Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients. BMC Nephrol. 2020;21:271.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiaoyan J, Rongyi C, Xuesen C, Jianzhou Z, Jun J, Xiaoqiang D, et al. The difference of T cell phenotypes in end stage renal disease patients under different dialysis modality. BMC Nephrol. 2019;20:301.

Article  PubMed  PubMed Central  Google Scholar 

van Riemsdijk IC, Baan CC, Loonen EHM, Knoop CJ, Betonico GN, Niesters HGM, et al. T cells activate the tumor necrosis factor-α system during hemodialysis, resulting in tachyphylaxis. Kidney Int. 2001;59:883–92.

Article  PubMed  Google Scholar 

Meier P, Dayer E, Ronco P, Blanc E. Dysregulation of IL-2/IL-2R system alters proliferation of early activated CD4 + T cell subset in patients with end-stage renal failure. Clin Nephrol. 2005;63:8–21.

Article  CAS  PubMed  Google Scholar 

Xiang F, Cao X, Chen X, Zhang Z, Ding X, Zou J, et al. Decreased peripheral Naïve T cell number and its Role in Predicting Cardiovascular and infection events in Hemodialysis patients. Front Immunol. 2021;12:644627.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ducloux D, Legendre M, Bamoulid J, Saas P, Courivaud C, Crepin T. End-stage renal disease-related Accelerated Immune Senescence: is rejuvenation of the Immune System a therapeutic goal? Front Med. 2021;8:720402.

Article  Google Scholar 

Iio K, Kabata D, Iio R, Shibamoto S, Watanabe Y, Morita M, et al. Decreased thymic output predicts progression of chronic kidney disease. Immun Ageing A. 2023;20:8.

Article  CAS  Google Scholar 

Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune–metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14:576–90.

Article  CAS  PubMed  Google Scholar 

Naylor K, Li G, Vallejo AN, Lee W-W, Koetz K, Bryl E, et al. The influence of age on T cell generation and TCR diversity. J Immunol. 2005;174:7446–52.

Article  CAS  PubMed  Google Scholar 

Shawi M, Autexier C. Telomerase, senescence and ageing. Mech Ageing Dev. 2008;129:3–10.

Article  CAS  PubMed  Google Scholar 

Ben-Porath I, Weinberg RA. When cells get stressed: an integrative view of cellular senescence. J Clin Invest. 2004;113:8–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yousefzadeh MJ, Zhao J, Bukata C, Wade EA, McGowan SJ, Angelini LA, et al. Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. Aging Cell. 2020;19:e13094.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herranz N, Gil J. Mechanisms and functions of cellular senescence. J Clin Invest. 2018;128:1238–46.

Article  PubMed  PubMed Central  Google Scholar 

Martínez-Zamudio RI, Dewald HK, Vasilopoulos T, Gittens‐Williams L, Fitzgerald‐Bocarsly P, Herbig U. Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8 + T cells in aging humans. Aging Cell. 2021;20:e13344.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Ibrahim JG et al. Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging. Aging Cell. 2009;8:439–48.

Herzog CA, Asinger RW, Berger AK, Charytan DM, Díez J, Hart RG, et al. Cardiovascular disease in chronic kidney disease. A clinical update from kidney disease: improving global outcomes (KDIGO). Kidney Int. 2011;80:572–86.

Article  PubMed  Google Scholar 

Wang L, Dai Y, Liu S, Lai L, Yan Q, Chen H, et al. Assessment of variation in B-cell receptor heavy chain repertoire in patients with end-stage renal disease by high-throughput sequencing. Ren Fail. 2019;41:1–13.

Article  PubMed  PubMed Central  Google Scholar 

Huang L, Betjes MGH, Klepper M, Langerak AW, Baan CC, Litjens NHR. End-stage renal disease causes skewing in the TCR Vβ-Repertoire primarily within CD8 + T cell subsets. Front Immunol. 2017;8:1826.

Article  PubMed  PubMed Central  Google Scholar 

Huang L, Langerak AW, Wolvers-Tettero ILM, Meijers RWJ, Baan CC, Litjens NHR, et al. End stage renal disease patients have a skewed T cell receptor Vβ repertoire. Immun Ageing. 2015;12:28.

Article  PubMed  PubMed Central  Google Scholar 

Zhang X, Zeng J, Tong Y, Zhang L, Lu X, Zhu S, et al. CDR3 sequences in IgA nephropathy are shorter and exhibit reduced diversity. FEBS Open Bio. 2020;10:2702–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Cui Y, Zhang Y, Liu Z, Zhang Q, Wu W, et al. A comprehensive study of immunology repertoires in both preoperative stage and postoperative stage in patients with colorectal cancer. Mol Genet Genomic Med. 2019;7:e504.

Article  PubMed  PubMed Central  Google Scholar 

Ahmed M, Lanzer KG, Yager EJ, Adams PS, Johnson LL, Blackman MA. Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice. J Immunol. 2009;182:784–92.

Article  CAS  PubMed  Google Scholar 

Libby P, Egan D, Skarlatos S. Roles of Infectious agents in atherosclerosis and Restenosis1. Circulation. 1997;96:4095–103.

Article  CAS  PubMed  Google Scholar 

Zal B, Kaski JC, Arno G, Akiyu JP, Xu Q, Cole D, et al. Heat-shock protein 60-Reactive CD4 + CD28null T cells in patients with Acute Coronary syn