Kehat I, Molkentin JD. Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation. 2010;122(25):2727–35.

Article  PubMed  Google Scholar 

Tanai E, Frantz S. Pathophysiology of heart failure. Compr Physiol. 2011;6(1):187–214.

Google Scholar 

Pitoulis FG, Terracciano CM. Heart plasticity in response to pressure-and volume-overload: a review of findings in compensated and decompensated phenotypes. Front Physiol. 2020;11:92.

Article  PubMed  PubMed Central  Google Scholar 

Dorn GW. The fuzzy logic of physiological cardiac hypertrophy. Hypertension. 2007;49(5):962–70.

Article  CAS  PubMed  Google Scholar 

Khalafbeigui F, Suga H, Sagawa K. Left ventricular systolic pressure-volume area correlates with oxygen consumption. Am J Physiol. 1979;237(5):H566–9.

CAS  PubMed  Google Scholar 

Suga H. Total mechanical energy of a ventricle model and cardiac oxygen consumption. Am J Physiol-Heart Circ Physiol. 1979;236(3):H498–505.

Article  CAS  Google Scholar 

Suga H, Hayashi T, Shirahata M. Ventricular systolic pressure-volume area as predictor of cardiac oxygen consumption. Am J Physiol. 1981;240(1):H39-44.

CAS  PubMed  Google Scholar 

Ohgoshi Y, et al. Sensitivities of cardiac O2 consumption and contractility to catecholamines in dogs. Am J Physiol-Heart Circ Physiol. 1991;261(1):H196–205.

Article  CAS  Google Scholar 

Suga H. Ventricular energetics. Physiol Rev. 1990;70(2):247–77.

Article  CAS  PubMed  Google Scholar 

Burkhoff D, Sagawa K. Ventricular efficiency predicted by an analytical model. Am J Physiol-Reg, Integr Comp Physiol. 1986;250(6):R1021–7.

Article  CAS  Google Scholar 

Asanoi H, Sasayama S, Kameyama T. Ventriculoarterial coupling in normal and failing heart in humans. Circ Res. 1989;65(2):483–93.

Article  CAS  PubMed  Google Scholar 

Kyriacou A, et al. Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally. Int J Cardiol. 2014;171(2):144–52.

Article  PubMed  PubMed Central  Google Scholar 

Schreuder JJ, et al. Acute decrease of left ventricular mechanical dyssynchrony and improvement of contractile state and energy efficiency after left ventricular restoration. J Thorac Cardiovasc Surg. 2005;129(1):138–45.

Article  PubMed  Google Scholar 

Watson WD, et al. Myocardial energy response to glyceryl trinitrate: physiology revisited. Front Physiol. 2021;12: 790525.

Article  PubMed  PubMed Central  Google Scholar 

Scott JV, et al. Right ventricular myocardial energetic model for evaluating right heart function in pulmonary arterial hypertension. Physiol Rep. 2022;10(10): e15136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pironet A, et al. Simulation of left atrial function using a multi-scale model of the cardiovascular system. PLoS ONE. 2013;8(6): e65146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bertero E, Maack C. Metabolic remodelling in heart failure. Nat Rev Cardiol. 2018;15(8):457–70.

Article  CAS  PubMed  Google Scholar 

Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev. 2005;85(3):1093–129.

Article  CAS  PubMed  Google Scholar 

Karwi QG, et al. Loss of metabolic flexibility in the failing heart. Front Cardiovasc Med. 2018;5:68.

Article  PubMed  PubMed Central  Google Scholar 

Balaban RS, et al. Relation between work and phosphate metabolite in the in vivo paced mammalian heart. Science. 1986;232(4754):1121–3.

Article  CAS  PubMed  Google Scholar 

Naumova AV, Weiss RG, Chacko VP. Regulation of murine myocardial energy metabolism during adrenergic stress studied by in vivo 31P NMR spectroscopy. Am J Physiol Heart Circ Physiol. 2003;285(5):H1976–9.

Article  CAS  PubMed  Google Scholar 

Schaefer S, et al. Metabolic response of the human heart to inotropic stimulation: in vivo phosphorus-31 studies of normal and cardiomyopathic myocardium. Magn Reson Med. 1992;25(2):260–72.

Article  CAS  PubMed  Google Scholar 

Saks V, et al. Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands. J Physiol. 2006;577(Pt 3):769–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guzun R, et al. Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiol. 2015;213(1):84–106.

Article  CAS  Google Scholar 

Bose S, et al. Metabolic network control of oxidative phosphorylation: multiple roles of inorganic phosphate. J Biol Chem. 2003;278(40):39155–65.

Article  CAS  PubMed  Google Scholar 

Saks V, et al. Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. J Physiol. 2006;571(2):253–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arad M, Seidman CE, Seidman JG. AMP-activated protein kinase in the heart. Circ Res. 2007;100(4):474–88.

Article  CAS  PubMed  Google Scholar 

Hue L, Taegtmeyer H. The Randle cycle revisited: a new head for an old hat. Am J Physiol-Endocrinol Metab. 2009;297(3):E578–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balaban RS, et al. Role of calcium in metabolic signaling between cardiac sarcoplasmic reticulum and mitochondria in vitro. Am J Physiol Cell Physiol. 2003;284(2):C285–93.

Article  CAS  PubMed  Google Scholar 

Denton RM, McCormack JG. On the role of the calcium transport cycle in heart and other mammalian mitochondria. FEBS Lett. 1980;119(1):1–8.

Article  CAS  PubMed  Google Scholar 

Territo PR, et al. Ca2+ activation of heart mitochondrial oxidative phosphorylation: role of the F0/F1-ATPase. Am J Physiol Cell Physiol. 2000;278(2):C423–35.

Article  CAS  PubMed  Google Scholar 

Angin Y, et al. Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake. Am J Physiol-Endocrinol Metab. 2014;307(2):E225–36.

Article  CAS  PubMed  Google Scholar 

Brandes R, Bers DM. Simultaneous measurements of mitochondrial NADH and Ca2+ during increased work in intact rat heart trabeculae. Biophys J. 2002;83(2):587–604.

Article  CAS