Pharmacological inhibition of RUNX1 reduces infarct size after acute myocardial infarction in rats and underlying mechanism revealed by proteomics implicates repressed cathepsin levels

Amrute JM, Lai L, Ma P, Koenig AL, Kamimoto K, Bredemeyer A, Shankar TS, Kuppe C, Kadyrov FF, Schulte LJ et al (2023) Defining cardiac functional recovery in end-stage heart failure at single-cell resolution. Nat Cardiovasc Res 2(4):399–416

Article  PubMed  PubMed Central  Google Scholar 

Bhoopathi P, Chetty C, Gujrati M, Dinh DH, Rao JS, Lakka S (2010) Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells. Cell Death Differ 17(10):1529–1539

Article  CAS  PubMed  Google Scholar 

Bulluck H, Yellon DM, Hausenloy DJ (2016) Reducing myocardial infarct size: challenges and future opportunities. Heart (British Cardiac Society) 102(5):341–348

CAS  PubMed  Google Scholar 

Burgener SS, Leborgne NGF, Snipas SJ, Salvesen GS, Bird PI, Benarafa C (2019) Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation. Cell Rep 27(12):3646–3656.e3645

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campden RI, Warren AL, Greene CJ, Chiriboga JA, Arnold CR, Aggarwal D, McKenna N, Sandall CF, MacDonald JA, Yates RM (2022) Extracellular cathepsin Z signals through the α(5) integrin and augments NLRP3 inflammasome activation. J Biol Chem 298(1):101459

Article  CAS  PubMed  Google Scholar 

Chaitanya GV, Alexander JS, Babu PP (2010) PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun Signal 8(1):31

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chareonthaitawee P, Christian TF, Hirose K, Gibbons RJ, Rumberger JA (1995) Relation of initial infarct size to extent of left ventricular remodeling in the year after acute myocardial infarction. J Am Coll Cardiol 25(3):567–573

Article  CAS  PubMed  Google Scholar 

Conus S, Simon HU (2008) Cathepsins: key modulators of cell death and inflammatory responses. Biochem Pharmacol 76(11):1374–1382

Article  CAS  PubMed  Google Scholar 

Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L et al (2012) Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction. Proc Natl Acad Sci U S A 109(36):14592–14597

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Castro MAG, Bunt G, Wouters FS (2016) Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes. Cell Death Discov 2(1):16012

Article  PubMed  PubMed Central  Google Scholar 

Deiss LP, Galinka H, Berissi H, Cohen O, Kimchi A (1996) Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. The EMBO J 15(15):3861–3870

Article  CAS  PubMed  Google Scholar 

Del Buono MG, Montone RA, Rinaldi R, Gurgoglione FL, Meucci MC, Camilli M, Iannaccone G, Sanna T, Pedicino D, Trani C et al (2021) Clinical predictors and prognostic role of high Killip class in patients with a first episode of anterior ST-segment elevation acute myocardial infarction. J Cardiovasc Med 22(7):530–538

Article  Google Scholar 

Del Buono MG, Moroni F, Montone RA, Azzalini L, Sanna T, Abbate A (2022) Ischemic Cardiomyopathy and Heart Failure After Acute Myocardial Infarction. Curr Cardiol Rep 24(10):1505–1515

Article  PubMed  PubMed Central  Google Scholar 

Delgado-Tirado S, Amarnani D, Zhao G, Rossin EJ, Eliott D, Miller JB, Greene WA, Ramos L, Arevalo-Alquichire S, Leyton-Cifuentes D et al (2020) Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy. Sci Rep 10(1):20554

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding X, Zhang C, Chen H, Ren M, Liu X (2022) Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma. Cells 11(24):4108

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elagib KE, Racke FK, Mogass M, Khetawat R, Delehanty LL, Goldfarb AN (2003) RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation. Blood 101(11):4333–4341

Article  CAS  PubMed  Google Scholar 

Elena-Real CA, Díaz-Quintana A, González-Arzola K, Velázquez-Campoy A, Orzáez M, López-Rivas A, Gil-Caballero S, De la Rosa M, Díaz-Moreno I (2018) Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition. Cell Death Dis 9(3):365

Article  PubMed  PubMed Central  Google Scholar 

Eulalio A, Mano M, Dal Ferro M, Zentilin L, Sinagra G, Zacchigna S, Giacca M (2012) Functional screening identifies miRNAs inducing cardiac regeneration. Nature 492(7429):376–381

Article  CAS  PubMed  Google Scholar 

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW et al (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 25(3):486–541

Article  PubMed  PubMed Central  Google Scholar 

Gao K, Zhang F, Chen K, Li W, Guan Y-B, Xu M-L, Chong T, Dai Z-M (2021) Expression patterns and prognostic value of RUNX genes in kidney cancer. Sci Rep 11(1):14934

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia-Dorado D, Ruiz-Meana M, Inserte J, Rodriguez-Sinovas A, Piper HM (2012) Calcium-mediated cell death during myocardial reperfusion. Cardiovasc Res 94(2):168–180

Article  CAS  PubMed  Google Scholar 

Gattenlohner S, Waller C, Ertl G, Bultmann BD, Muller-Hermelink HK, Marx A (2003) NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia. Am J Pathol 163(3):1081–1090

Article  PubMed  PubMed Central  Google Scholar 

Grossmann V, Bacher U, Kohlmann A, Butschalowski K, Roller A, Jeromin S, Dicker F, Kern W, Schnittger S, Haferlach T et al (2012) Expression of CEBPA is reduced in RUNX1-mutated acute myeloid leukemia. Blood Cancer J 2(8):e86–e86

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo H, Ma O, Speck NA, Friedman AD (2012) Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis. Blood 119(19):4408–4418

Article  CAS  PubMed  PubMed Central  Google Scholar 

He W, McCarroll CS, Nather K, Ford K, Mangion K, Riddell A, O'Toole D, Zaeri A, Corcoran D, Carrick D et al (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. Cardiovasc Res 118(6):1535–1547

Article  CAS  PubMed  Google Scholar 

Heimer S, Knoll G, Schulze-Osthoff K, Ehrenschwender M (2019) Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis. Cell Death Dis 10(8):556

Article  PubMed  PubMed Central  Google Scholar 

Heusch G (2020) Myocardial ischaemia–reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17(12):773–789

Article  PubMed  Google Scholar 

Ichikawa M, Asai T, Chiba S, Kurokawa M, Ogawa S (2004) Runx1/AML-1 Ranks as a Master Regulator of Adult Hematopoiesis. Cell Cycle 3(6):720–722

Article  Google Scholar 

Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H et al (2016) Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine 8:117–131

Article  PubMed  PubMed Central 

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