Unraveling Estrogen and PCSK9’s Roles in Lipid Metabolism Disorders among Ovariectomized Mice

Palmisano BT, Zhu L, Stafford JM. Role of Estrogens in the regulation of liver lipid metabolism. Adv Exp Med Biol. 2017;1043:227–56. https://doi.org/10.1007/978-3-319-70178-3_12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lloyd-Jones D, et al. Heart disease and stroke statistics–2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119(3):480–6. https://doi.org/10.1161/circulationaha.108.191259.

Article  PubMed  Google Scholar 

Wilmot KA, et al. Coronary heart Disease Mortality declines in the United States from 1979 through 2011: evidence for stagnation in young adults, especially women. Circulation. 2015;132(11):997–1002. https://doi.org/10.1161/circulationaha.115.015293.

Article  PubMed  PubMed Central  Google Scholar 

Anagnostis P, et al. Effects of menopause, gender and age on lipids and high-density lipoprotein cholesterol subfractions. Maturitas. 2015;81(1):62–8. https://doi.org/10.1016/j.maturitas.2015.02.262.

Article  CAS  PubMed  Google Scholar 

Roger VL, et al. Heart disease and stroke statistics–2011 update: a report from the American Heart Association. Circulation. 2011;123(4):e18–209. https://doi.org/10.1161/CIR.0b013e3182009701.

Article  PubMed  Google Scholar 

O’Hare EA, et al. Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia. J Lipid Res. 2014;55(11):2242–53. https://doi.org/10.1194/jlr.M046540.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horton JD, Cohen JC, Hobbs HH. PCSK9: a convertase that coordinates LDL catabolism J Lipid Res, 2009;50 Suppl(Suppl):S172-7. https://doi.org/10.1194/jlr.R800091-JLR200.

Roelfsema F, Yang RJ, Veldhuis JD. Differential effects of Estradiol and Progesterone on Cardiovascular Risk factors in Postmenopausal Women. J Endocr Soc. 2018;2(7):794–805. https://doi.org/10.1210/js.2018-00073.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schnatz PF, et al. Effects of Calcium, Vitamin D, and hormone therapy on Cardiovascular Disease Risk factors in the women’s Health Initiative: a Randomized Controlled Trial. Obstet Gynecol. 2017;129(1):121–9. https://doi.org/10.1097/aog.0000000000001774.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jackson KG, et al. Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed. Am J Clin Nutr. 2002;76(5):942–9. https://doi.org/10.1093/ajcn/76.5.942.

Article  CAS  PubMed  Google Scholar 

Parini P, Angelin B, Rudling M. Importance of estrogen receptors in hepatic LDL receptor regulation. Arterioscler Thromb Vasc Biol. 1997;17(9):1800–5. https://doi.org/10.1161/01.atv.17.9.1800.

Article  CAS  PubMed  Google Scholar 

Ribas V, et al. Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. Am J Physiol Endocrinol Metab. 2010;298(2). https://doi.org/10.1152/ajpendo.00504.2009. p. E304-19.

Geary N, et al. Deficits in E2-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-alpha null mice. Endocrinology. 2001;142(11):4751–7. https://doi.org/10.1210/endo.142.11.8504.

Article  CAS  PubMed  Google Scholar 

Li C, et al. Requirement of Sp1 and estrogen receptor alpha interaction in 17beta-estradiol-mediated transcriptional activation of the low density lipoprotein receptor gene expression. Endocrinology. 2001;142(4):1546–53. https://doi.org/10.1210/endo.142.4.8096.

Article  CAS  PubMed  Google Scholar 

Villablanca AC et al. 17beta-estradiol prevents early-stage atherosclerosis in estrogen receptor-alpha deficient female mice J Cardiovasc Transl Res, 2009;2(3):289– 99. https://doi.org/10.1007/s12265-009-9103-z.

Wang Y, et al. Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR. J Lipid Res. 2012;53(9):1932–43. https://doi.org/10.1194/jlr.M028563.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui Q, et al. Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population. Atherosclerosis. 2010;213(2):632–6. https://doi.org/10.1016/j.atherosclerosis.2010.09.027.

Article  CAS  PubMed  Google Scholar 

Fu W, et al. 17β-Estradiol inhibits PCSK9-Mediated LDLR degradation through GPER/PLC activation in HepG2 cells. Front Endocrinol (Lausanne). 2019;10:930. https://doi.org/10.3389/fendo.2019.00930.

Article  PubMed  Google Scholar 

Guo WJ, et al. Contribution of high-fat diet-induced PCSK9 upregulation to a mouse model of PCOS is mediated partly by SREBP2. Reproduction. 2021;162(6):397–410. https://doi.org/10.1530/rep-21-0164.

Article  CAS  PubMed  Google Scholar 

Lakoski SG, et al. Genetic and metabolic determinants of plasma PCSK9 levels. J Clin Endocrinol Metab. 2009;94(7):2537–43. https://doi.org/10.1210/jc.2009-0141.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruscica M, et al. Circulating levels of Proprotein Convertase Subtilisin/Kexin Type 9 and arterial stiffness in a large Population Sample: Data from the Brisighella Heart Study. J Am Heart Assoc. 2017;6(5). https://doi.org/10.1161/jaha.117.005764.

Jeenduang N. Circulating PCSK9 concentrations are increased in postmenopausal women with the metabolic syndrome. Clin Chim Acta. 2019;494:151–6. https://doi.org/10.1016/j.cca.2019.04.067.

Article  CAS  PubMed  Google Scholar 

Cariou B, et al. PCSK9 dominant negative mutant results in increased LDL catabolic rate and familial hypobetalipoproteinemia. Arterioscler Thromb Vasc Biol. 2009;29(12):2191–7. https://doi.org/10.1161/atvbaha.109.194191.

Article  CAS  PubMed  Google Scholar 

Cohen JC, et al. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med. 2006;354(12):1264–72. https://doi.org/10.1056/NEJMoa054013.

Article  CAS  PubMed  Google Scholar 

Rashid S, et al. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A. 2005;102(15):5374–9. https://doi.org/10.1073/pnas.0501652102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ooi TC, et al. Relationship between testosterone, estradiol and circulating PCSK9: cross-sectional and interventional studies in humans. Clin Chim Acta. 2015;446:97–104. https://doi.org/10.1016/j.cca.2015.03.036.

Article  CAS  PubMed  Google Scholar 

Persson L, et al. Importance of proprotein convertase subtilisin/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors. Endocrinology. 2009;150(3):1140–6. https://doi.org/10.1210/en.2008-1281.

Article  CAS  PubMed  Google Scholar 

Ghosh M, et al. Influence of physiological changes in endogenous estrogen on circulating PCSK9 and LDL cholesterol. J Lipid Res. 2015;56(2):463–9. https://doi.org/10.1194/jlr.M055780.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Starr AE, et al. β-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells. Febs j. 2015;282(14):2682–96. https://doi.org/10.1111/febs.13309.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roubtsova A et al. PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2022;1867(12). https://doi.org/10.1016/j.bbalip.2022.159217.

Maarouf N, et al. Unlike estrogens that increase PCSK9 levels post-menopause HSP27 vaccination lowers cholesterol levels and atherogenesis due to divergent effects on PCSK9 and LDLR. Pharmacol Res. 2020;161. https://doi.org/10.1016/j.phrs.2020.105222.

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