These authors contributed equally: Junjiao Yang, Chan-I Chung.

Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA

Junjiao Yang, Chan-I Chung, Hao He, Zhimin Ma, Qian Zhao, Liang He & Xiaokun Shu

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA

Junjiao Yang, Chan-I Chung, Hao He, Zhimin Ma, Qian Zhao, Liang He & Xiaokun Shu

Departments of Neurology, Neurological Surgery, Pediatrics, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA

Jessica Koach & William A. Weiss

Institute for Human Genetics, Departments of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA

Hongjiang Liu, Xiaoyu Yang & Yin Shen

Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

Ambuja Navalkar & Tanja Mittag

Helen Diller Family Comprehensive Center, University of California, San Francisco, San Francisco, CA, USA

Xiaokun Shu