van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017;17:407–20. https://doi.org/10.1038/nri.2017.36.
Article CAS PubMed Google Scholar
Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the global burden of disease study. Lancet. 2020;395:200–11. https://doi.org/10.1016/s0140-6736(19)32989-7.
Article PubMed PubMed Central Google Scholar
Hattori Y, Hattori K, Suzuki T, Matsuda N. Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: novel therapeutic implications and challenges. Pharmacol Ther. 2017;177:56–66. https://doi.org/10.1016/j.pharmthera.2017.02.040.
Article CAS PubMed Google Scholar
Pinsky MR, Vincent JL, Deviere J, Alegre M, Kahn RJ, Dupont E. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest. 1993;103:565–75. https://doi.org/10.1378/chest.103.2.565.
Article CAS PubMed Google Scholar
Dalli J, Colas RA, Quintana C, et al. Human sepsis eicosanoid and proresolving lipid mediator temporal profiles: correlations with survival and clinical outcomes. Crit Care Med. 2017;45:58–68. https://doi.org/10.1097/ccm.0000000000002014.
Article CAS PubMed PubMed Central Google Scholar
Hara S. Prostaglandin terminal synthases as novel therapeutic targets. Proc Jpn Acad Ser B Phys Biol Sci. 2017;93:703–23. https://doi.org/10.2183/pjab.93.044.
Article CAS PubMed PubMed Central Google Scholar
Lee BH, Inui D, Suh GY, et al. Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Crit Care. 2012;16:R33. https://doi.org/10.1186/cc11211.
Article PubMed PubMed Central Google Scholar
Maehara T, Higashitarumi F, Kondo R, Fujimori K. Prostaglandin F2α receptor antagonist attenuates LPS-induced systemic inflammatory response in mice. FASEB J. 2020;34:15197–207. https://doi.org/10.1096/fj.202001481R.
Article CAS PubMed Google Scholar
Ishii M, Asano K, Namkoong H, et al. CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis. J Immunol. 2012;188:5655–64. https://doi.org/10.4049/jimmunol.1102330.
Article CAS PubMed Google Scholar
Choudhry MA, Ahmad S, Sayeed MM. Role of Ca2+ in prostaglandin E2-induced T-lymphocyte proliferative suppression in sepsis. Infect Immun. 1995;63:3101–5. https://doi.org/10.1128/iai.63.8.3101-3105.1995.
Article CAS PubMed PubMed Central Google Scholar
Ochiai T, Honsawa T, Sasaki Y, Hara S. Prostacyclin Synthase as an ambivalent regulator of inflammatory reactions. Biol Pharm Bull. 2022;45:979–84. https://doi.org/10.1248/bpb.b22-00370.
Article CAS PubMed Google Scholar
Ochiai T, Sasaki Y, Yokoyama C, Kuwata H, Hara S. Absence of prostacyclin greatly relieves cyclophosphamide-induced cystitis and bladder pain in mice. FASEB J. 2021;35:e21952. https://doi.org/10.1096/fj.202101025R.
Article CAS PubMed Google Scholar
Ochiai T, Sasaki Y, Kuwata H, Nakatani Y, Yokoyama C, Hara S. Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity. Biochem Biophys Res Commun. 2021;546:124–9. https://doi.org/10.1016/j.bbrc.2021.02.004.
Article CAS PubMed Google Scholar
Ipseiz N, Pickering RJ, Rosas M, et al. Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway. EMBO J. 2020;39:103454.
Kuwata H, Nakatani E, Tomitsuka Y, et al. Deficiency of long-chain acyl-CoA synthetase 4 leads to lipopolysaccharide-induced mortality in a mouse model of septic shock. FASEB J. 2023;37:e23330. https://doi.org/10.1096/fj.202301314R.
Article CAS PubMed Google Scholar
Liu L, Xu M, Zhang Z, et al. TRPA1 protects mice from pathogenic Citrobacter rodentium infection via maintaining the colonic epithelial barrier function. FASEB J. 2023;37:e22739. https://doi.org/10.1096/fj.202200483RRR.
Article CAS PubMed Google Scholar
Takeuchi Y, Kikusui T, Mori Y. Changes in the behavioral parameters following the lipopolysaccharide administration in goats. J Vet Med Sci. 1995;57:1041–4. https://doi.org/10.1292/jvms.57.1041.
Article CAS PubMed Google Scholar
Chen H, Shen Y, Liang Y, Qiu Y, Xu M, Li C. Selexipag improves lipopolysaccharide-induced ARDS on C57BL/6 mice by modulating the cAMP/PKA and cAMP/Epac1 signaling pathways. Biol Pharm Bull. 2022;45:1043–52. https://doi.org/10.1248/bpb.b21-01057.
Article CAS PubMed Google Scholar
Muendlein HI, Connolly WM, Magri Z, et al. ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF. Proc Natl Acad Sci U S A. 2022;119:e2113872119. https://doi.org/10.1073/pnas.2113872119.
Article CAS PubMed PubMed Central Google Scholar
Nassar A, Sharon-Granit Y, Azab AN. Psychotropic drugs attenuate lipopolysaccharide-induced hypothermia by altering hypothalamic levels of inflammatory mediators in rats. Neurosci Lett. 2016;626:59–67. https://doi.org/10.1016/j.neulet.2016.05.019.
Article CAS PubMed Google Scholar
Machado NLS, Bandaru SS, Abbott SBG, Saper CB. EP3R-expressing glutamatergic preoptic neurons mediate inflammatory fever. J Neurosci. 2020;40:2573–88. https://doi.org/10.1523/jneurosci.2887-19.2020.
Article CAS PubMed PubMed Central Google Scholar
Sasaki Y, Kamiyama S, Kamiyama A, et al. Genetic-deletion of cyclooxygenase-2 downstream prostacyclin synthase suppresses inflammatory reactions but facilitates carcinogenesis, unlike deletion of microsomal prostaglandin E synthase-1. Sci Rep. 2015;5:17376. https://doi.org/10.1038/srep17376.
Article CAS PubMed PubMed Central Google Scholar
Toki S, Zhou W, Goleniewska K, et al. Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model. Prostaglandins Other Lipid Mediat. 2018;136:33–43. https://doi.org/10.1016/j.prostaglandins.2018.04.001.
Article CAS PubMed PubMed Central Google Scholar
Zhou W, Zhang J, Goleniewska K, et al. Prostaglandin I2 suppresses proinflammatory chemokine expression, CD4 T cell activation, and STAT6-independent allergic lung inflammation. J Immunol. 2016;197:1577–86. https://doi.org/10.4049/jimmunol.1501063.
Article CAS PubMed Google Scholar
Takahashi Y, Tokuoka S, Masuda T, et al. Augmentation of allergic inflammation in prostanoid IP receptor deficient mice. Br J Pharmacol. 2002;137:315–22. https://doi.org/10.1038/sj.bjp.0704872.
Article CAS PubMed PubMed Central Google Scholar
Misawa H, Ohashi W, Tomita K, et al. Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Toxicol Appl Pharmacol. 2017;334:55–65. https://doi.org/10.1016/j.taap.2017.09.003.
Article CAS PubMed Google Scholar
Kuwano K, Hashino A, Asaki T, et al. 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J Pharmacol Exp Ther. 2007;322:1181–8. https://doi.org/10.1124/jpet.107.124248.
Article CAS PubMed Google Scholar
Abramovitz M, Adam M, Boie Y, et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000;1483:285–93. https://doi.org/10.1016/s1388-1981(99)00164-x.
Article CAS PubMed Google Scholar
Sitbon O, Channick R, Chin KM, et al. Selexipag for the treatment of pulmonary arterial hypertension. N Engl J Med. 2015;373:2522–33. https://doi.org/10.1056/NEJMoa1503184.
留言 (0)