Moreira GC, Cipullo JP, Ciorlia LA, Cesarino CB, Vilela-Martin JF. Prevalence of metabolic syndrome: association with risk factors and cardiovascular complications in an urban population. PLoS ONE. 2014;9(9): e105056. https://doi.org/10.1371/journal.pone.0105056.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uzunlulu M, Telci Caklili O, Oguz A. Association between metabolic syndrome and cancer. Ann Nutr Metab. 2016;68(3):173–9. https://doi.org/10.1159/000443743.

Article  CAS  PubMed  Google Scholar 

Tune JD, Goodwill AG, Sassoon DJ, Mather KJ. Cardiovascular consequences of metabolic syndrome. Transl Res. 2017;183:57–70. https://doi.org/10.1016/j.trsl.2017.01.001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chin KY, Wong SK, Ekeuku SO, Pang KL. Relationship between metabolic syndrome and bone health - an evaluation of epidemiological studies and mechanisms involved. Diabetes Metab Syndr Obes. 2020;13(13):3667–90. https://doi.org/10.2147/DMSO.S275560.

Article  PubMed  PubMed Central  Google Scholar 

Regufe VMG, Pinto CMCB, Perez PMVHC. Metabolic syndrome in type 2 diabetic patients: a review of current evidence. Porto Biomed J. 2020;5(6):e101. https://doi.org/10.1097/j.pbj.0000000000000101.

Article  PubMed  PubMed Central  Google Scholar 

Pammer LM, Lamina C, Schultheiss UT, Kotsis F, Kollerits B, Stockmann H, Lipovsek J, Meiselbach H, Busch M, Eckardt KU, Kronenberg F; GCKD Investigators (2021) Association of the metabolic syndrome with mortality and major adverse cardiac events: a large chronic kidney disease cohort. J Intern Med. 290(6):1219–1232. https://doi.org/10.1111/joim.13355.

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr; International Diabetes Federation Task Force on Epidemiology and Prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120(16):1640–1645. https://doi.org/10.1161/CIRCULATIONAHA.109.192644.

Tang X, Wu M, Wu S, Tian Y. Continuous metabolic syndrome severity score and the risk of CVD and all-cause mortality. Eur J Clin Invest. 2022;52(9): e13817. https://doi.org/10.1111/eci.13817.

Article  PubMed  Google Scholar 

Osadebe PO, Odoh EU, Uzor PF. Natural products as potential sources of antidiabetic drugs. JPRI. 2014;4(17):2075–9. https://doi.org/10.9734/BJPR/2014/8382.

Article  Google Scholar 

Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity: a systematic and clinical review. JAMA. 2014;311(1):74–86. https://doi.org/10.1001/jama.2013.281361.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen JB, Gadde KM. Weight Loss Medications in the Treatment of Obesity and Hypertension. Curr Hypertens Rep. 2019;21(2):16. https://doi.org/10.1007/s11906-019-0915-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yanovski SZ, Yanovski JA. Progress in pharmacotherapy for obesity. JAMA. 2021;326(2):129–30. https://doi.org/10.1001/jama.2021.9486.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Müller TD, Clemmensen C, Finan B, DiMarchi RD, Tschöp MH. Anti-obesity therapy: from rainbow pills to polyagonists. Pharmacol Rev. 2018;70(4):712–46. https://doi.org/10.1124/pr.117.014803.

Article  CAS  PubMed  Google Scholar 

Müller TD, Blüher M, Tschöp MH, DiMarchi RD. Anti-obesity drug discovery: advances and challenges. Nat Rev Drug Discov. 2022;21(3):201–23. https://doi.org/10.1038/s41573-021-00337-8.

Article  CAS  PubMed  Google Scholar 

Kabat M, Bobkov I, Kumar S, Grumet M. Trends in mesenchymal stem cell clinical trials 2004–2018: Is efficacy optimal in a narrow dose range? Stem Cells Transl Med. 2020;9(1):17–27. https://doi.org/10.1002/sctm.19-0202.

Article  CAS  PubMed  Google Scholar 

Planat-Benard V, Varin A, Casteilla L. MSCs and inflammatory cells crosstalk in regenerative medicine: concerted actions for optimized resolution driven by energy metabolism. Front Immunol. 2021;30(12): 626755. https://doi.org/10.3389/fimmu.2021.626755.

Article  CAS  Google Scholar 

Rodríguez-Fuentes DE, Fernández-Garza LE, Samia-Meza JA, Barrera-Barrera SA, Caplan AI, Barrera-Saldaña HA. Mesenchymal stem cells current clinical applications: a systematic review. Arch Med Res. 2021;52(1):93–101. https://doi.org/10.1016/j.arcmed.2020.08.006.

Article  CAS  PubMed  Google Scholar 

Santra L, Gupta S, Singh AK, Sahu AR, Gandham RK, Naskar S, Maity SK, Ghosh J, Dhara SK. A comparative analysis of invasive and non-invasive method of bone marrow stromal cell isolation. AJAVA. 2015;10(10):549–55. https://doi.org/10.3923/ajava.2015.549.555.

Article  CAS  Google Scholar 

Weiss ML, Troyer DL. Stem cells in the umbilical cord. Stem Cell Rev. 2006;2(2):155–62. https://doi.org/10.1007/s12015-006-0022-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vangsness CT Jr, Sternberg H, Harris L. Umbilical cord tissue offers the greatest number of harvestable mesenchymal stem cells for research and clinical application: a literature review of different harvest sites. Arthroscopy. 2015;31(9):1836–43. https://doi.org/10.1016/j.arthro.2015.03.014.

Article  PubMed  Google Scholar 

Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019;2(4):22. https://doi.org/10.1038/s41536-019-0083-6.

Article  CAS  Google Scholar 

Musiał-Wysocka A, Kot M, Majka M. The pros and cons of mesenchymal stem cell-based therapies. Cell Transplant. 2019;28(7):801–12. https://doi.org/10.1177/0963689719837897.

Article  PubMed  PubMed Central  Google Scholar 

Bhat S, Viswanathan P, Chandanala S, Prasanna SJ, Seetharam RN. Expansion and characterization of bone marrow derived human mesenchymal stromal cells in serum-free conditions. Sci Rep. 2021;11(1):3403. https://doi.org/10.1038/s41598-021-83088-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muthu S, Bapat A, Jain R, Jeyaraman N, Jeyaraman M. Exosomal therapy-a new frontier in regenerative medicine. Stem Cell Investig. 2021;2(8):7. https://doi.org/10.21037/sci-2020-037.

Article  CAS  Google Scholar 

De Becker A, Riet IV. Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy? World J Stem Cells. 2016;8(3):73–87. https://doi.org/10.4252/wjsc.v8.i3.73.

Article  PubMed  PubMed Central  Google Scholar 

Galleu A, Riffo-Vasquez Y, Trento C, Lomas C, Dolcetti L, Cheung TS, von Bonin M, Barbieri L, Halai K, Ward S, Weng L, Chakraverty R, Lombardi G, Watt FM, Orchard K, Marks DI, Apperley J, Bornhauser M, Walczak H, Bennett C, Dazzi F (2017) Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation. Science Transl Med 9(416):eaam7828. https://doi.org/10.1126/scitranslmed.aam7828

Cheung TS, Galleu A, von Bonin M, Bornhäuser M, Dazzi F. Apoptotic mesenchymal stromal cells induce prostaglandin E2 in monocytes: implications for the monitoring of mesenchymal stromal cell activity. Haematologica. 2019;104(10):e438–41. https://doi.org/10.3324/haematol.2018.214767.

Article  PubMed  PubMed Central  Google Scholar 

Chan AML, Ng AMH, Mohd Yunus MH, Hj Idrus RB, Law JX, Yazid MD, Chin KY, Shamsuddin SA, Mohd Yusof MR, Razali RA, Mat Afandi MA, Hassan MNF, Ng SN, Koh B, Lokanathan Y. Safety study of allogeneic mesenchymal stem cell therapy in animal model. Regen Ther. 2022;17(19):158–65. https://doi.org/10.1016/j.reth.2022.01.008.

Article  CAS  Google Scholar 

Alencar AKN, Pimentel-Coelho PM, Montes GC, da Silva MMC, Mendes LVP, Montagnoli TL, Silva AMS, Vasques JF, Rosado-de-Castro PH, Gutfilen B, Cunha VDMN, Fraga AGM, Silva PMRE, Martins MA, Ferreira TPT, Mendes-Otero R, Trachez MM, Sudo RT, Zapata-Sudo G. Human mesenchymal stem cell therapy reverses Su5416/hypoxia-induced pulmonary arterial hypertension in mice. Front Pharmacol. 2018;6(9):1395. https://doi.org/10.3389/fphar.2018.01395.

Article  CAS  Google Scholar 

Lominadze Z, Kallwitz ER. Misconception: you can’t have liver disease with normal liver chemistries. Clin Liver Dis (Hoboken). 2018;12(4):96–9. https://doi.org/10.1002/cld.742.

Article  PubMed  Google Scholar 

Zafar M, Naqvi SN. Effects of STZ-induced diabetes on the relative weights of kidney, liver and pancreas in albino rat