Murnane JP. Telomere dysfunction and chromosome instability. Mutat Res. 2012;730(1–2):28–36.
Article CAS PubMed Google Scholar
Zhong FL, Batista LF, Freund A, Pech MF, Venteicher AS, Artandi SE. TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell. 2012;150(3):481–94.
Article CAS PubMed PubMed Central Google Scholar
Sakellariou D, Chiourea M, Raftopoulou C, Gagos S. Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction. Neoplasia. 2013;15(11):1301–13.
Article CAS PubMed PubMed Central Google Scholar
Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 1992;11(5):1921–9.
Article CAS PubMed PubMed Central Google Scholar
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194–217.
Article PubMed PubMed Central Google Scholar
Chakravarti D, LaBella KA, DePinho RA. Telomeres: history, health, and hallmarks of aging. Cell. 2021;184(2):306–22.
Article CAS PubMed PubMed Central Google Scholar
Gadhave K, Kumar P, Kapuganti SK, Uversky VN, Giri R. Unstructured Biology of proteins from Ubiquitin-Proteasome System: roles in Cancer and neurodegenerative diseases. Biomolecules 2020, 10(5).
Harman CA, Monteiro MJ. The specificity of ubiquitin binding to ubiquilin-1 is regulated by sequences besides its UBA domain. Biochim Biophys Acta Gen Subj. 2019;1863(10):1568–74.
Article CAS PubMed PubMed Central Google Scholar
Itakura E, Zavodszky E, Shao S, Wohlever ML, Keenan RJ, Hegde RS. Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for degradation. Mol Cell. 2016;63(1):21–33.
Article CAS PubMed PubMed Central Google Scholar
Whiteley AM, Prado MA, Peng I, Abbas AR. Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins. 2017, 6.
Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, et al. Family-based association between Alzheimer’s disease and variants in UBQLN1. N Engl J Med. 2005;352(9):884–94.
Article CAS PubMed Google Scholar
Haapasalo A, Viswanathan J, Bertram L, Soininen H, Tanzi RE, Hiltunen M. Emerging role of Alzheimer’s disease-associated ubiquilin-1 in protein aggregation. Biochem Soc Trans. 2010;38(Pt 1):150–5.
Article CAS PubMed Google Scholar
Xiao X, Yuan Z, Guo L, Liao X, Zhou Y, Zhang W, Zhou L, Wang X, Liu X, Liu H, et al. The role of frontotemporal dementia associated genes in patients with Alzheimer’s disease. Neurobiol Aging. 2021;107:153–8.
Article CAS PubMed Google Scholar
Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, Bohr VA. Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol. 2019;15(10):565–81.
Jenkins EC, Marchi EJ, Velinov MT, Ye L, Krinsky-McHale SJ, Zigman WB, Schupf N, Silverman WP. Longitudinal telomere shortening and early Alzheimer’s disease progression in adults with down syndrome. Am J Med Genet B Neuropsychiatr Genet. 2017;174(8):772–8.
Article CAS PubMed Google Scholar
Lee EH, Han MH, Ha J, Park HH, Koh SH, Choi SH, Lee JH. Relationship between telomere shortening and age in Korean individuals with mild cognitive impairment and Alzheimer’s disease compared to that in healthy controls. Aging. 2020;13(2):2089–100.
Article PubMed PubMed Central Google Scholar
Liu M, Huo YR, Wang J, Wang C, Liu S, Liu S, Wang J, Ji Y. Telomere Shortening in Alzheimer’s Disease patients. Ann Clin Lab Sci. 2016;46(3):260–5.
Panossian LA, Porter VR, Valenzuela HF, Zhu X, Reback E, Masterman D, Cummings JL, Effros RB. Telomere shortening in T cells correlates with Alzheimer’s disease status. Neurobiol Aging. 2003;24(1):77–84.
Article CAS PubMed Google Scholar
Wang H, Zhang K, Liu Y, Fu Y, Gao S, Gong P, Wang H, Zhou Z, Zeng M, Wu Z, et al. Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell. BMC Biol. 2017;15(1):114.
Article PubMed PubMed Central Google Scholar
Liu CC, Ma DL, Yan TD, Fan X, Poon Z, Poon LF, Goh SA, Rozen SG, Hwang WY, Tergaonkar V, et al. Distinct responses of stem cells to Telomere Uncapping-A potential strategy to improve the safety of cell therapy. Stem Cells. 2016;34(10):2471–84.
Article CAS PubMed Google Scholar
Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, et al. Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell. 2019;10(9):649–67.
Article CAS PubMed PubMed Central Google Scholar
Rivera T, Haggblom C, Cosconati S, Karlseder J. A balance between elongation and trimming regulates telomere stability in stem cells. Nat Struct Mol Biol. 2017;24(1):30–9.
Article CAS PubMed Google Scholar
Mathew R, Jia W, Sharma A, Zhao Y, Clarke LE, Cheng X, Wang H, Salli U, Vrana KE, Robertson GP, et al. Robust activation of the human but not mouse telomerase gene during the induction of pluripotency. FASEB J. 2010;24(8):2702–15.
Article CAS PubMed PubMed Central Google Scholar
Yang C, Przyborski S, Cooke MJ, Zhang X, Stewart R, Anyfantis G, Atkinson SP, Saretzki G, Armstrong L, Lako M. A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation. Stem Cells. 2008;26(4):850–63.
Article CAS PubMed Google Scholar
Amit M, Carpenter MK, Inokuma MS, Chiu CP, Harris CP, Waknitz MA, Itskovitz-Eldor J, Thomson JA. Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol. 2000;227(2):271–8.
Article CAS PubMed Google Scholar
Zeng S, Liu L, Sun Y, Xie P, Hu L, Yuan D, Chen D, Ouyang Q, Lin G, Lu G. Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells. J Cell Sci. 2014;127(Pt 4):752–62.
Sexton AN, Regalado SG, Lai CS, Cost GJ, O’Neil CM, Urnov FD, Gregory PD, Jaenisch R, Collins K, Hockemeyer D. Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation. Genes Dev. 2014;28(17):1885–99.
Article CAS PubMed PubMed Central Google Scholar
Hockemeyer D, Collins K. Control of telomerase action at human telomeres. Nat Struct Mol Biol. 2015;22(11):848–52.
Article CAS PubMed PubMed Central Google Scholar
Choo S, Lorbeer FK, Regalado SG, Short SB, Wu S, Rieser G, Bertuch AA, Hockemeyer D. Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita. Blood. 2022;140(6):608–18.
Article CAS PubMed PubMed Central Google Scholar
Li F, Ge Y, Liu D, Songyang Z. The role of telomere-binding modulators in pluripotent stem cells. Protein Cell. 2020;11(1):60–70.
留言 (0)