McCormick F, Harris JD, Abrams GD, Frank R, Gupta A, Hussey K, et al. Trends in the surgical treatment of articular cartilage lesions in the United States: an analysis of a large private-payer database over a period of 8 years. Arthroscopy. 2014;30:222–6.

Article  PubMed  Google Scholar 

McAdams TR, Mithoefer K, Scopp JM, Mandelbaum BR. Articular cartilage Injury in athletes. Cartilage. 2010;1:165–79.

Article  PubMed  PubMed Central  Google Scholar 

Volz M, Schaumburger J, Frick H, Grifka J, Anders S. A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years. Int Orthop. 2017;41:797–804.

Article  PubMed  Google Scholar 

Karami P, Stampoultzis T, Guo Y, Pioletti DP. A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions. Acta Biomater. 2023;158:12–31.

Article  CAS  PubMed  Google Scholar 

Baroli B. Hydrogels for tissue engineering and delivery of tissue-inducing substances. J Pharm Sci. 2007;96:2197–223.

Article  CAS  PubMed  Google Scholar 

He C, Clark KL, Tan J, Zhou H, Tuan RS, Lin H, et al. Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models. Stem Cell Res Ther. 2022;13:400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balakrishnan B, Banerjee R. Biopolymer-based hydrogels for cartilage tissue engineering. Chem Rev. 2011;111:4453–74.

Article  CAS  PubMed  Google Scholar 

Elisseeff J. Injectable cartilage tissue engineering. Expert Opin Biol Ther. 2004;4:1849–59.

Article  CAS  PubMed  Google Scholar 

Orth P, Madry H. Complex and elementary histological scoring systems for articular cartilage repair. Histol Histopathol. 2015;30:911–9.

PubMed  Google Scholar 

Rothrauff BB, Coluccino L, Gottardi R, Ceseracciu L, Scaglione S, Goldoni L, et al. Efficacy of thermoresponsive, photocrosslinkable hydrogels derived from decellularized tendon and cartilage extracellular matrix for cartilage tissue engineering. J Tissue Eng Regen Med. 2018;12:e159–70.

Article  CAS  PubMed  Google Scholar 

Lin H, Cheng AW, Alexander PG, Beck AM, Tuan RS. Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution. Tissue Eng Part A. 2014;20:2402–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Slimi F, Zribi W, Trigui M, Amri R, Gouiaa N, Abid C, et al. The effectiveness of platelet-rich plasma gel on full-thickness cartilage defect repair in a rabbit model. Bone Joint Res. 2021;10:192–202.

Article  PubMed  PubMed Central  Google Scholar 

Xie X, Wang Y, Zhao C, Guo S, Liu S, Jia W, et al. Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration. Biomaterials. 2012;33:7008–18.

Article  CAS  PubMed  Google Scholar 

Xu Z, Yin W, Zhang Y, Qi X, Chen Y, Xie X, et al. Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration. Sci Rep. 2017;7:43301.

Article  PubMed  PubMed Central  Google Scholar 

Liou JJ, Rothrauff BB, Alexander PG, Tuan RS. Effect of platelet-rich plasma on chondrogenic differentiation of adipose- and bone marrow-derived mesenchymal stem cells. Tissue Eng Part A. 2018;24:1432–43.

Article  CAS  PubMed  Google Scholar 

Chapman HS, Gale AL, Dodson ME, Linardi RL, Ortved KF. Autologous platelet lysate does not enhance chondrogenic differentiation of equine bone marrow-derived mesenchymal stromal cells despite increased TGF-beta1 concentration. Stem Cells Dev. 2020;29:144–55.

Article  CAS  PubMed  Google Scholar 

Amable PR, Carias RB, Teixeira MV, da Cruz Pacheco I, Correa do Amaral RJ, Granjeiro JM, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther. 2013;4:67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan X, Yuan S, Xun X, Fan Z, Xue X, Zhang C, et al. Long-term recruitment of endogenous M2 macrophages by platelet lysate-rich plasma Macroporous Hydrogel Scaffold for articular cartilage defect repair. Adv Healthc Mater. 2022;11:e2101661.

Article  PubMed  Google Scholar 

Beigi MH, Atefi A, Ghanaei HR, Labbaf S, Ejeian F, Nasr-Esfahani MH. Activated platelet-rich plasma improves cartilage regeneration using adipose stem cells encapsulated in a 3D alginate scaffold. J Tissue Eng Regen Med. 2018;12:1327–38.

Article  CAS  PubMed  Google Scholar 

Caplan AI, Correa D. The MSC: an injury drugstore. Cell Stem Cell. 2011;9:11–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maumus M, Guerit D, Toupet K, Jorgensen C, Noel D. Mesenchymal stem cell-based therapies in regenerative medicine: applications in rheumatology. Stem Cell Res Ther. 2011;2:14.

Article  PubMed  PubMed Central  Google Scholar 

Calori GM, Colombo M, Mazza EL, Mazzola S, Malagoli E, Mineo GV. Incidence of donor site morbidity following harvesting from iliac crest or RIA graft. Injury. 2014;45(Suppl 6):S116–20.

Article  PubMed  Google Scholar 

Li M, Luo X, Lv X, Liu V, Zhao G, Zhang X, et al. In vivo human adipose-derived mesenchymal stem cell tracking after intra-articular delivery in a rat osteoarthritis model. Stem Cell Res Ther. 2016;7:160.

Article  PubMed  PubMed Central  Google Scholar 

Hsu YK, Sheu SY, Wang CY, Chuang MH, Chung PC, Luo YS, et al. The effect of adipose-derived mesenchymal stem cells and chondrocytes with platelet-rich fibrin releasates augmentation by intra-articular injection on acute osteochondral defects in a rabbit model. Knee. 2018;25:1181–91.

Article  PubMed  Google Scholar 

Spakova T, Amrichova J, Plsikova J, Harvanova D, Hornak S, Ledecky V, et al. A preliminary Study comparing microfracture and local adherent transplantation of autologous adipose-derived stem cells followed by Intraarticular Injection of Platelet-Rich Plasma for the treatment of Chondral defects in rabbits. Cartilage. 2018;9:410–6.

Article  PubMed  Google Scholar 

Van Pham P, Bui KH, Ngo DQ, Vu NB, Truong NH, Phan NL, et al. Activated platelet-rich plasma improves adipose-derived stem cell transplantation efficiency in injured articular cartilage. Stem Cell Res Ther. 2013;4:91.

Article  PubMed  PubMed Central  Google Scholar 

Fairbanks BD, Schwartz MP, Bowman CN, Anseth KS. Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility. Biomaterials. 2009;30:6702–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A. Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res. 2000:212–34.

Smith GD, Taylor J, Almqvist KF, Erggelet C, Knutsen G, Garcia Portabella M, et al. Arthroscopic assessment of cartilage repair: a validation study of 2 scoring systems. Arthroscopy. 2005;21:1462–7.

Article  PubMed  Google Scholar 

Hayes WC, Keer LM, Herrmann G, Mockros LF. A mathematical analysis for indentation tests of articular cartilage. J Biomech. 1972;5:541–51.

Article  CAS  PubMed  Google Scholar 

Hoch DH, Grodzinsky AJ, Koob TJ, Albert ML, Eyre DR. Early changes in material properties of rabbit articular cartilage after meniscectomy. J Orthop Res. 1983;1:4–12.

Article  CAS  PubMed  Google Scholar 

Delaine-Smith RM, Burney S, Balkwill FR, Knight MM. Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics. J Mech Behav Biomed Mater. 2016;60:401–15.

Article  CAS  PubMed  Google Scholar 

Schinagl RM, Gurskis D, Chen AC, Sah RL. Depth-dependent confined compression modulus of full-thickness bovine articular cartilage. J Orthop Res. 1997;15:499–506.

Article  CAS  PubMed  Google Scholar 

Lim A, Protsenko DE, Wong BJ. Changes in the tangent modulus of rabbit septal and auricular cartilage following electromechanical reshaping. J Biomech Eng. 2011;133:094502.

Article  PubMed  Google Scholar 

Freeman TA, Patel P, Parvizi J, Antoci V Jr., Shapiro IM. Micro-CT analysis with multiple thresholds allows detection of bone formation and resorption during ultrasound-treated fracture healing. J Orthop Res. 2009;27:673–9.

Article  PubMed  Google Scholar 

Voor MJ, Yang S, Burden RL, Waddell SW. In vivo micro-CT scanning of a rabbit distal femur: repeatability and reproducibility. J Biomech. 2008;41:186–93.

Article  PubMed  Google Scholar 

Maruyama M, Satake H, Suzuki T, Honma R, Naganuma Y, Takakubo Y, et al. Comparison of the effects of Osteochondral Autograft Transplantation with platelet-rich plasma or platelet-rich fibrin on Osteochondral defects in a rabbit model. Am J Sports Med. 2017;45:3280–8.

Article  PubMed