TGF-β signaling regulates differentiation of MSCs in bone metabolism: disputes among viewpoints

Jann J, Gascon S, Roux S, Faucheux N. Influence of the TGF-β superfamily on Osteoclasts/Osteoblasts balance in physiological and pathological bone conditions. Int J Mol Sci. 2020;21:7597.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao D, Huang L, Ke J, Zhang M, Xiao Q, Zhu X. Bone metabolism regulation: implications for the treatment of bone diseases. Biomed Pharmacother. 2020;129:110494.

Article  CAS  PubMed  Google Scholar 

Shi H, Zhou K, Wang M, Wang N, Song Y, Xiong W, et al. Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs. Theranostics. 2023;13:3245–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bruder SP, Fink DJ, Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem. 1994;56:283–94.

Article  CAS  PubMed  Google Scholar 

Ponzetti M, Rucci N. Osteoblast differentiation and signaling: established concepts and emerging topics. Int J Mol Sci. 2021;22:6651.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou J-Q, Wan H-Y, Wang Z-X, Jiang N. Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. World J Stem Cells. 2023;15:369–84.

Article  PubMed  PubMed Central  Google Scholar 

Lee JH, Massagué J. TGF-β in developmental and fibrogenic EMTs. Semin Cancer Biol. 2022;86:136–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen W. TGF-β regulation of T cells. Annu Rev Immunol. 2023;41:483–512.

Article  PubMed  Google Scholar 

Gough NR, Xiang X, Mishra L. TGF-β signaling in liver, pancreas, and gastrointestinal diseases and Cancer. Gastroenterology. 2021;161:434–52.

Article  CAS  PubMed  Google Scholar 

Chen J, Chang R. Association of TGF-β Canonical Signaling-related core genes with aortic aneurysms and aortic dissections. Front Pharmacol. 2022;13:888563.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guasto A, Cormier-Daire V. Signaling pathways in Bone Development and their related skeletal dysplasia. Int J Mol Sci 2021;22.

Song IW, Nagamani SC, Nguyen D, Grafe I, Sutton VR, Gannon FH et al. Targeting TGF-β for treatment of osteogenesis imperfecta. J Clin Invest 2022;132.

Velchev JD, Van Laer L, Luyckx I. Dietz HLoeys B. Loeys-Dietz Syndrome. Adv Exp Med Biol. 2021;1348:251–64.

Article  CAS  PubMed  Google Scholar 

Matsunobu T, Torigoe K, Ishikawa M, de Vega S, Kulkarni AB, Iwamoto Y, et al. Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol. 2009;332:325–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seo H-S, Serra R. Tgfbr2 is required for development of the skull vault. Dev Biol. 2009;334:481–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Ayoub A, Xiu Y, Yin X, Sanders JO, Mesfin A, et al. TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. Nat Commun. 2019;10:2795.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Wang H, Ni Q, Wang T, Bao C, Geng Y, et al. B-Cell-derived TGF-β1 inhibits Osteogenesis and contributes to bone loss in Periodontitis. J Dent Res. 2023;102:767–76.

Article  CAS  PubMed  Google Scholar 

Vander Ark A, Cao J, Li X. TGF-β receptors: in and beyond TGF-β signaling. Cell Signal. 2018;52:112–20.

Article  CAS  PubMed  Google Scholar 

López-Casillas F, Payne HM, Andres JL, Massagué J. Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. J Cell Biol. 1994;124:557–68.

Article  PubMed  Google Scholar 

Sánchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, et al. The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior. Dev Biol. 2011;358:331–43.

Article  PubMed  PubMed Central  Google Scholar 

Tazat K, Hector-Greene M, Blobe GC, Henis YI. TβRIII independently binds type I and type II TGF-β receptors to inhibit TGF-β signaling. Mol Biol Cell. 2015;26:3535–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi Y, Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685–700.

Article  CAS  PubMed  Google Scholar 

Tzavlaki K, Moustakas A, TGF-β Signaling. Biomolecules. 2020;10:487.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schlunegger MP, Grütter MG. Refined crystal structure of human transforming growth factor beta 2 at 1.95 a resolution. J Mol Biol. 1993;231:445–58.

Article  CAS  PubMed  Google Scholar 

Ogawa Y, Schmidt DK, Dasch JR, Chang RJ, Glaser CB. Purification and characterization of transforming growth factor-beta 2.3 and -beta 1.2 heterodimers from bovine bone. J Biol Chem. 1992;267:2325–8.

Article  CAS  PubMed  Google Scholar 

Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, et al. Latent TGF-β structure and activation. Nature. 2011;474:343–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franzén P, Heldin CH, Miyazono K. The GS domain of the transforming growth factor-beta type I receptor is important in signal transduction. Biochem Biophys Res Commun. 1995;207:682–9.

Article  PubMed  Google Scholar 

Lin HY, Wang XF, Ng-Eaton E, Weinberg R. ALodish H F. expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell. 1992;68:775–85.

Article  CAS  PubMed  Google Scholar 

Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J. Mechanism of activation of the TGF-beta receptor. Nature. 1994;370:341–7.

Article  CAS  PubMed  Google Scholar 

Radaev S, Zou Z, Huang T, Lafer EM, Hinck AP, Sun PD. Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. J Biol Chem. 2010;285:14806–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

López-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massagué J. Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system. Cell. 1991;67:785–95.

Article  PubMed  Google Scholar 

Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, et al. Binding properties of the transforming growth Factor-β Coreceptor Betaglycan: proposed mechanism for Potentiation of Receptor Complex Assembly and Signaling. Biochemistry. 2016;55:6880–96.

Article  CAS  PubMed  Google Scholar 

Kim SK, Henen MA, Hinck AP. Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family. Exp Biol Med (Maywood). 2019;244:1547–58.

Article  CAS  PubMed  Google Scholar 

López-Casillas F, Wrana JL, Massagué J. Betaglycan presents ligand to the TGF beta signaling receptor. Cell. 1993;73:1435–44.

Article  PubMed  Google Scholar 

Aashaq S, Batool A, Mir SA, Beigh MA, Andrabi KI, Shah ZA. TGF-β signaling: a recap of SMAD-independent and SMAD-dependent pathways. J Cell Physiol. 2022;237:59–85.

Article  CAS  PubMed  Google Scholar 

Derynck R, Budi EH. Specificity, versatility, and control of TGF-β family signaling. Sci Signal 2019;12.

Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell. 1998;95:779–91.

Article  CAS  PubMed  Google Scholar 

Hill CS. Nucleocytoplasmic shuttling of smad proteins. Cell Res. 2009;19:36–46.

Article  CAS  PubMed  Google Scholar 

David CJ, Massagué J. Contextual determinants of TGFβ action in development, immunity and cancer. Nat Rev Mol Cell Biol. 2018;19:419–35.

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