Jann J, Gascon S, Roux S, Faucheux N. Influence of the TGF-β superfamily on Osteoclasts/Osteoblasts balance in physiological and pathological bone conditions. Int J Mol Sci. 2020;21:7597.
Article CAS PubMed PubMed Central Google Scholar
Yao D, Huang L, Ke J, Zhang M, Xiao Q, Zhu X. Bone metabolism regulation: implications for the treatment of bone diseases. Biomed Pharmacother. 2020;129:110494.
Article CAS PubMed Google Scholar
Shi H, Zhou K, Wang M, Wang N, Song Y, Xiong W, et al. Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs. Theranostics. 2023;13:3245–75.
Article CAS PubMed PubMed Central Google Scholar
Bruder SP, Fink DJ, Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem. 1994;56:283–94.
Article CAS PubMed Google Scholar
Ponzetti M, Rucci N. Osteoblast differentiation and signaling: established concepts and emerging topics. Int J Mol Sci. 2021;22:6651.
Article CAS PubMed PubMed Central Google Scholar
Zhou J-Q, Wan H-Y, Wang Z-X, Jiang N. Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. World J Stem Cells. 2023;15:369–84.
Article PubMed PubMed Central Google Scholar
Lee JH, Massagué J. TGF-β in developmental and fibrogenic EMTs. Semin Cancer Biol. 2022;86:136–45.
Article CAS PubMed PubMed Central Google Scholar
Chen W. TGF-β regulation of T cells. Annu Rev Immunol. 2023;41:483–512.
Gough NR, Xiang X, Mishra L. TGF-β signaling in liver, pancreas, and gastrointestinal diseases and Cancer. Gastroenterology. 2021;161:434–52.
Article CAS PubMed Google Scholar
Chen J, Chang R. Association of TGF-β Canonical Signaling-related core genes with aortic aneurysms and aortic dissections. Front Pharmacol. 2022;13:888563.
Article CAS PubMed PubMed Central Google Scholar
Guasto A, Cormier-Daire V. Signaling pathways in Bone Development and their related skeletal dysplasia. Int J Mol Sci 2021;22.
Song IW, Nagamani SC, Nguyen D, Grafe I, Sutton VR, Gannon FH et al. Targeting TGF-β for treatment of osteogenesis imperfecta. J Clin Invest 2022;132.
Velchev JD, Van Laer L, Luyckx I. Dietz HLoeys B. Loeys-Dietz Syndrome. Adv Exp Med Biol. 2021;1348:251–64.
Article CAS PubMed Google Scholar
Matsunobu T, Torigoe K, Ishikawa M, de Vega S, Kulkarni AB, Iwamoto Y, et al. Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol. 2009;332:325–38.
Article CAS PubMed PubMed Central Google Scholar
Seo H-S, Serra R. Tgfbr2 is required for development of the skull vault. Dev Biol. 2009;334:481–90.
Article CAS PubMed PubMed Central Google Scholar
Li J, Ayoub A, Xiu Y, Yin X, Sanders JO, Mesfin A, et al. TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. Nat Commun. 2019;10:2795.
Article PubMed PubMed Central Google Scholar
Chen Y, Wang H, Ni Q, Wang T, Bao C, Geng Y, et al. B-Cell-derived TGF-β1 inhibits Osteogenesis and contributes to bone loss in Periodontitis. J Dent Res. 2023;102:767–76.
Article CAS PubMed Google Scholar
Vander Ark A, Cao J, Li X. TGF-β receptors: in and beyond TGF-β signaling. Cell Signal. 2018;52:112–20.
Article CAS PubMed Google Scholar
López-Casillas F, Payne HM, Andres JL, Massagué J. Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. J Cell Biol. 1994;124:557–68.
Sánchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, et al. The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior. Dev Biol. 2011;358:331–43.
Article PubMed PubMed Central Google Scholar
Tazat K, Hector-Greene M, Blobe GC, Henis YI. TβRIII independently binds type I and type II TGF-β receptors to inhibit TGF-β signaling. Mol Biol Cell. 2015;26:3535–45.
Article CAS PubMed PubMed Central Google Scholar
Shi Y, Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685–700.
Article CAS PubMed Google Scholar
Tzavlaki K, Moustakas A, TGF-β Signaling. Biomolecules. 2020;10:487.
Article CAS PubMed PubMed Central Google Scholar
Schlunegger MP, Grütter MG. Refined crystal structure of human transforming growth factor beta 2 at 1.95 a resolution. J Mol Biol. 1993;231:445–58.
Article CAS PubMed Google Scholar
Ogawa Y, Schmidt DK, Dasch JR, Chang RJ, Glaser CB. Purification and characterization of transforming growth factor-beta 2.3 and -beta 1.2 heterodimers from bovine bone. J Biol Chem. 1992;267:2325–8.
Article CAS PubMed Google Scholar
Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, et al. Latent TGF-β structure and activation. Nature. 2011;474:343–9.
Article CAS PubMed PubMed Central Google Scholar
Franzén P, Heldin CH, Miyazono K. The GS domain of the transforming growth factor-beta type I receptor is important in signal transduction. Biochem Biophys Res Commun. 1995;207:682–9.
Lin HY, Wang XF, Ng-Eaton E, Weinberg R. ALodish H F. expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell. 1992;68:775–85.
Article CAS PubMed Google Scholar
Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J. Mechanism of activation of the TGF-beta receptor. Nature. 1994;370:341–7.
Article CAS PubMed Google Scholar
Radaev S, Zou Z, Huang T, Lafer EM, Hinck AP, Sun PD. Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. J Biol Chem. 2010;285:14806–14.
Article CAS PubMed PubMed Central Google Scholar
López-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massagué J. Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system. Cell. 1991;67:785–95.
Villarreal MM, Kim SK, Barron L, Kodali R, Baardsnes J, Hinck CS, et al. Binding properties of the transforming growth Factor-β Coreceptor Betaglycan: proposed mechanism for Potentiation of Receptor Complex Assembly and Signaling. Biochemistry. 2016;55:6880–96.
Article CAS PubMed Google Scholar
Kim SK, Henen MA, Hinck AP. Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family. Exp Biol Med (Maywood). 2019;244:1547–58.
Article CAS PubMed Google Scholar
López-Casillas F, Wrana JL, Massagué J. Betaglycan presents ligand to the TGF beta signaling receptor. Cell. 1993;73:1435–44.
Aashaq S, Batool A, Mir SA, Beigh MA, Andrabi KI, Shah ZA. TGF-β signaling: a recap of SMAD-independent and SMAD-dependent pathways. J Cell Physiol. 2022;237:59–85.
Article CAS PubMed Google Scholar
Derynck R, Budi EH. Specificity, versatility, and control of TGF-β family signaling. Sci Signal 2019;12.
Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell. 1998;95:779–91.
Article CAS PubMed Google Scholar
Hill CS. Nucleocytoplasmic shuttling of smad proteins. Cell Res. 2009;19:36–46.
Article CAS PubMed Google Scholar
David CJ, Massagué J. Contextual determinants of TGFβ action in development, immunity and cancer. Nat Rev Mol Cell Biol. 2018;19:419–35.
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