Basdeo, S. A., Cluxton, D., Sulaimani, J., Moran, B., Canavan, M., Orr, C., Veale, D. J., Fearon, U., & Fletcher, J. M. (2017). Ex-Th17 (Nonclassical Th1) cells are functionally distinct from classical Th1 and Th17 cells and are not constrained by regulatory T cells. The Journal of Immunology, 198, 2249.

Article  CAS  PubMed  Google Scholar 

Daglas, M., Draxler, D. F., Ho, H., McCutcheon, F., Galle, A., Au, A. E., Larsson, P., Gregory, J., Alderuccio, F., Sashindranath, M., & Medcalf, R. L. (2019). Activated CD8(+) T cells cause long-term neurological Impairment after traumatic brain injury in mice. Cell Reports, 29, 1178.

Article  CAS  PubMed  Google Scholar 

Diani, M., Casciano, F., Marongiu, L., Longhi, M., Altomare, A., Pigatto, P. D., Secchiero, P., Gambari, R., Banfi, G., Manfredi, A. A., Altomare, G., Granucci, F., & Reali, E. (2019). Increased frequency of activated CD8(+) T cell effectors in patients with psoriatic arthritis. Science and Reports, 9, 10870.

Article  Google Scholar 

Fergusson, J. R., Fleming, V. M., & Klenerman, P. (2011). CD161-expressing human T cells. Frontiers in Immunology, 2, 36.

Article  PubMed  PubMed Central  Google Scholar 

Huber, M., Heink, S., Pagenstecher, A., Reinhard, K., Ritter, J., Visekruna, A., Guralnik, A., Bollig, N., Jeltsch, K., Heinemann, C., Wittmann, E., Buch, T., Prazeres da Costa, O., Brustle, A., Brenner, D., Mak, T. W., Mittrucker, H. W., Tackenberg, B., Kamradt, T., & Lohoff, M. (2013). IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. The Journal of Clinical Investigation, 123, 247.

Article  CAS  PubMed  Google Scholar 

Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019). Neuroinflammation: Friend and foe for ischemic stroke. Journal of Neuroinflammation, 16, 142.

Article  PubMed  PubMed Central  Google Scholar 

Kondo, T., Takata, H., Matsuki, F., & Takiguchi, M. (2009). Cutting edge: Phenotypic characterization and differentiation of human CD8+ T cells producing IL-17. The Journal of Immunology, 182, 1794.

Article  CAS  PubMed  Google Scholar 

Liesz, A., Karcher, S., & Veltkamp, R. (2013). Spectratype analysis of clonal T cell expansion in murine experimental stroke. Journal of Neuroimmunology, 257, 46.

Article  CAS  PubMed  Google Scholar 

Livak, K. J., & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods, 25, 402.

Article  CAS  PubMed  Google Scholar 

Loyal, L., Warth, S., Jurchott, K., Molder, F., Nikolaou, C., Babel, N., Nienen, M., Durlanik, S., Stark, R., Kruse, B., Frentsch, M., Sabat, R., Wolk, K., & Thiel, A. (2020). SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8(+) T cells. Nature Communications, 11, 6357.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luckel, C., Picard, F. S. R., & Huber, M. (2020). Tc17 biology and function: Novel concepts. European Journal of Immunology, 50, 1257.

Article  PubMed  Google Scholar 

Luckel, C., Picard, F., Raifer, H., Campos Carrascosa, L., Guralnik, A., Zhang, Y., Klein, M., Bittner, S., Steffen, F., Moos, S., Marini, F., Gloury, R., Kurschus, F. C., Chao, Y. Y., Bertrams, W., Sexl, V., Schmeck, B., Bonetti, L., Grusdat, M., … Huber, M. (2019). IL-17(+) CD8(+) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nature Communications, 10, 5722.

Article  PubMed  PubMed Central  Google Scholar 

Ma, R., Xie, Q., Li, Y., Chen, Z., Ren, M., Chen, H., Li, H., Li, J., & Wang, J. (2020). Animal models of cerebral ischemia: A review. Biomedicine & Pharmacotherapy, 131, 110686.

Article  CAS  Google Scholar 

Maeda, S., Osaga, S., Maeda, T., Takeda, N., Tamechika, S. Y., Naniwa, T., & Niimi, A. (2019). Circulating Th17.1 cells as candidate for the prediction of therapeutic response to abatacept in patients with rheumatoid arthritis: An exploratory research. PLoS ONE, 14, e0215192.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miro-Mur, F., Urra, X., Ruiz-Jaen, F., Pedragosa, J., Chamorro, A., & Planas, A. M. (2020). Antigen-dependent t cell response to neural peptides after human ischemic stroke. Frontiers in Cellular Neuroscience, 14, 206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nanjappa, S. G., McDermott, A. J., Fites, J. S., Galles, K., Wuthrich, M., Deepe, G. S., Jr., & Klein, B. S. (2017). Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNgamma cells. PLoS Pathogens, 13, e1006356.

Article  PubMed  PubMed Central  Google Scholar 

Nanjappa, S. G., Hernandez-Santos, N., Galles, K., Wuthrich, M., Suresh, M., & Klein, B. S. (2015). Intrinsic myD88-Akt1-mTOR signaling coordinates disparate tc17 and tc1 responses during vaccine immunity against fungal pneumonia. PLoS Pathogens, 11, e1005161.

Article  PubMed  PubMed Central  Google Scholar 

Ohkuri, T., Kosaka, A., Ikeura, M., Salazar, A. M., & Okada, H. (2021). IFN-gamma- and IL-17-producing CD8(+) T (Tc17–1) cells in combination with poly-ICLC and peptide vaccine exhibit antiglioma activity. Journal for Immunotherapy of Cancer. https://doi.org/10.1136/jitc-2021-002426

Article  PubMed  PubMed Central  Google Scholar 

Paulissen, S. M., van Hamburg, J. P., Dankers, W., & Lubberts, E. (2015). The role and modulation of CCR6+ Th17 cell populations in rheumatoid arthritis. Cytokine, 74, 43.

Article  CAS  PubMed  Google Scholar 

Pick, J., Arra, A., Lingel, H., Hegel, J. K., Huber, M., Nishanth, G., Jorch, G., Fischer, K. D., Schluter, D., Tedford, K., & Brunner-Weinzierl, M. C. (2014). CTLA-4 (CD152) enhances the Tc17 differentiation program. European Journal of Immunology, 44, 2139.

Article  CAS  PubMed  Google Scholar 

Saxena, A., Desbois, S., Carrie, N., Lawand, M., Mars, L. T., & Liblau, R. S. (2012). Tc17 CD8+ T cells potentiate Th1-mediated autoimmune diabetes in a mouse model. The Journal of Immunology, 189, 3140.

Article  CAS  PubMed  Google Scholar 

Selvaraj, U. M., & Stowe, A. M. (2017). Long-term T cell responses in the brain after an ischemic stroke. Discovery Medicine, 24, 323.

PubMed  PubMed Central  Google Scholar 

Selvaraj, U. M., Ujas, T. A., Kong, X., Kumar, A., Plautz, E. J., Zhang, S., Xing, C., Sudduth, T. L., Wilcock, D. M., Turchan-Cholewo, J., Goldberg, M. P., & Stowe, A. M. (2021). Delayed diapedesis of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice. Brain, Behavior, and Immunity, 95, 502.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi, L., Sun, Z., Su, W., Xu, F., Xie, D., Zhang, Q., Dai, X., Iyer, K., Hitchens, T. K., Foley, L. M., Li, S., Stolz, D. B., Chen, K., Ding, Y., Thomson, A. W., Leak, R. K., Chen, J., & Hu, X. (2021). Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke. Immunity, 54, 1527.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tzartos, J. S., Friese, M. A., Craner, M. J., Palace, J., Newcombe, J., Esiri, M. M., & Fugger, L. (2008). Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. American Journal of Pathology, 172, 146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vindegaard, N., Munoz-Briones, C., El Ali, H. H., Kristensen, L. K., Rasmussen, R. S., Johansen, F. F., & Hasseldam, H. (2017). T-cells and macrophages peak weeks after experimental stroke: Spatial and temporal characteristics. Neuropathology, 37, 407.

Article  CAS  PubMed  Google Scholar 

Xie, L., Li, W., Hersh, J., Liu, R., & Yang, S. H. (2019). Experimental ischemic stroke induces long-term T cell activation in the brain. Journal of Cerebral Blood Flow and Metabolism, 39, 2268.

Article  CAS  PubMed  Google Scholar 

Zahran, A. M., Saad, K., Elsayh, K. I., Abdou, M. A. A., Abo-Elgheet, A. M., Eloseily, E. M., Khalaf, S. M., Sror, S., Ahmad, F. A., Elhoufey, A., Ghandour, A., & Osman, N. S. (2022). Upregulation of Cytotoxic T-cells in pediatric patients with gaucher disease. Science and Reports, 12, 4977.

Article  CAS  Google Scholar 

Zhang, D., Ren, J., Luo, Y., He, Q., Zhao, R., Chang, J., Yang, Y., & Guo, Z. N. (2021). T Cell response in ischemic stroke: From mechanisms to translational insights. Frontiers in Immunology, 12, 707972.

Article  CAS  PubMed  PubMed Central  Google Scholar