Establishing and Validating an Innovative Focal Adhesion-Linked Gene Signature for Enhanced Prognostic Assessment in Endometrial Cancer

Makker V, et al. Endometrial cancer. Nat Rev Dis Primers. 2021;7(1):88.

Article  PubMed  PubMed Central  Google Scholar 

Sung H, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30.

Article  PubMed  Google Scholar 

Brooks RA, et al. Current recommendations and recent progress in endometrial cancer. CA Cancer J Clin. 2019;69(4):258–79.

Article  PubMed  Google Scholar 

Janiszewska M, Primi MC, Izard T. Cell adhesion in cancer: Beyond the migration of single cells. J Biol Chem. 2020;295(8):2495–505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z, et al. Functional and clinical characteristics of focal adhesion kinases in cancer progression. Front Cell Dev Biol. 2022;10:1040311.

Article  PubMed  PubMed Central  Google Scholar 

McLean GW, et al. The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer. 2005;5(7):505–15.

Article  CAS  PubMed  Google Scholar 

Zhang P, et al. CPNE8 Promotes Gastric Cancer Metastasis by Modulating Focal Adhesion Pathway and Tumor Microenvironment. Int J Biol Sci. 2022;18(13):4932–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsujioka M, et al. Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression. Cell Death Dis. 2023;14(4):256.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, et al. LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway. Bioengineered. 2021;12(2):10089–100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu X, et al. Collagen triple helix repeat containing 1 promotes endometrial cancer cell migration by activating the focal adhesion kinase signaling pathway. Exp Ther Med. 2020;20(2):1405–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alowayed N, et al. LEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a. Cell Physiol Biochem. 2016;39(3):815–26.

Article  CAS  PubMed  Google Scholar 

Li Z, Gou J, Xu J. Down-regulation of focal adhesion signaling in response to cyclophilin A knockdown in human endometrial cancer cells, implicated by cDNA microarray analysis. Gynecol Oncol. 2013;131(1):191–7.

Article  CAS  PubMed  Google Scholar 

Gabriel B, et al. Expression of focal adhesion kinase in patients with endometrial cancer: a clinicopathologic study. Int J Gynecol Cancer. 2009;19(7):1221–5.

Article  PubMed  Google Scholar 

Tenenbaum D, Volkening J, Bioconductor Package Maintainer. KEGGREST: Client-side REST access to the Kyoto Encyclopedia of Genes and Genomes (KEGG). 2023. https://doi.org/10.18129/B9.bioc.KEGGREST, R package version 1.42.0, https://bioconductor.org/packages/KEGGREST.

Wu T, et al. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innovation. 2021;2(3):100141.

CAS  PubMed  PubMed Central  Google Scholar 

Castanza AS, et al. Extending support for mouse data in the Molecular Signatures Database (MSigDB). Nat Methods. 2023;20:1619–1620. https://doi.org/10.1038/s41592-023-02014-7

Hanzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 2013;14:7.

Article  PubMed  PubMed Central  Google Scholar 

Szklarczyk D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–13.

Article  CAS  PubMed  Google Scholar 

Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bader GD, Hogue CW. An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 2003;4:2.

Article  PubMed  PubMed Central  Google Scholar 

Geeleher P, Cox N, Huang RS. pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One. 2014;9(9):e107468.

Article  PubMed  PubMed Central  Google Scholar 

Subramanian A, et al. A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell. 2017;171(6):1437–1452 e17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

R Foundation for Statistical Computing. R: A language and environment for statistical computing. RA Lang Environ Stat Comput. 2018.

Wei S, et al. Identification of an integrated kinase-related prognostic gene signature associated with tumor immune microenvironment in human uterine corpus endometrial carcinoma. Front Oncol. 2022;12:944000.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen S, et al. Development of Biomarker Signatures Associated with Anoikis to Predict Prognosis in Endometrial Carcinoma Patients. J Oncol. 2021;2021:3375297.

Article  PubMed  PubMed Central  Google Scholar 

Liu J, et al. Development and clinical validation of novel 8-gene prognostic signature associated with the proportion of regulatory T cells by weighted gene co-expression network analysis in uterine corpus endometrial carcinoma. Front Immunol. 2021;12:788431.

Ruan T, et al. Identification of a Novel Epithelial-Mesenchymal Transition-Related Gene Signature for Endometrial Carcinoma Prognosis. Genes. 2022;13(2):216.

Malpica A. How to approach the many faces of endometrioid carcinoma. Mod Pathol. 2016;29(Suppl 1):S29–44.

Article  CAS  PubMed  Google Scholar 

Bai JDK, et al. Keratin 17 is a negative prognostic biomarker in high-grade endometrial carcinomas. Hum Pathol. 2019;94:40–50.

Article  CAS  PubMed  Google Scholar 

Siesser PF, Maness PF. L1 cell adhesion molecules as regulators of tumor cell invasiveness. Cell Adh Migr. 2009;3(3):275–7.

Article  PubMed  PubMed Central  Google Scholar 

Chaudhary PK, Kim S. An Insight into GPCR and G-Proteins as Cancer Drivers. Cells. 2021;10(12):3288.

Filardo EJ, et al. Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression. Clin Cancer Res. 2006;12(21):6359–66.

Article  CAS  PubMed  Google Scholar 

Yun CC, et al. LPA2 receptor mediates mitogenic signals in human colon cancer cells. Am J Physiol Cell Physiol. 2005;289(1):C2–11.

Article  CAS  PubMed  Google Scholar 

Komachi M, et al. Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo. Cancer Sci. 2012;103(6):1099–104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suzuki-Karasaki M, Ochiai T, Suzuki-Karasaki Y. Crosstalk between mitochondrial ROS and depolarization in the potentiation of TRAIL-induced apoptosis in human tumor cells. Int J Oncol. 2014;44(2):616–28.

Article  CAS  PubMed  Google Scholar 

Sabharwal SS, Schumacker PT. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? Nat Rev Cancer. 2014;14(11):709–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang T, Zhou J, Wang J. Calcium and calcium-related proteins in endometrial cancer: opportunities for pharmacological intervention. Int J Biol Sci. 2022;18(3):1065–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng Y, et al. High SPRR1A expression is associated with poor survival in patients with colon cancer. Oncol Lett. 2020;19(5):3417–24.

CAS  PubMed  PubMed Central  Google Scholar 

Yamakawa K, et al. Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma. PLoS One. 2022;17(5):e0266620.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z, et al. Identification of small proline-rich protein 1B (SPRR1B) as a prognostically predictive biomarker for lung adenocarcinoma by integrative bioinformatic analysis. Thorac Cancer. 2021;12(6):796–806.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu L, et al. Identification

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