Zoń A, Bednarek I. Cisplatin in ovarian cancer treatment—known limitations in therapy force new solutions. Int J Mol Sci. 2023;24(8):7585.

Article  PubMed  PubMed Central  Google Scholar 

Keshta AT, Fathallah AM, Attia YA, Salem EA, Watad SH. Ameliorative effect of selenium nanoparticles on testicular toxicity induced by cisplatin in adult male rats. Food Chem Toxicol. 2023;179:113979.

Article  CAS  PubMed  Google Scholar 

Wang TE, Lai YH, Yang KC, Lin SJ, Chen CL, Tsai PS. Counteracting cisplatin-induced testicular damages by natural polyphenol constituent honokiol. Antioxidants. 2020;9(8):723.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mesbahzadeh B, Hassanzadeh-Taheri M, Aliparast MS, Baniasadi P, Hosseini M. The protective effect of crocin on cisplatin-induced testicular impairment in rats. BMC Urol. 2021;21(1):117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jahan S, Munawar A, Razak S, Anam S, Ain QU, Ullah H, Almajwal A. Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats. BMC Urol. 2018;18(1):107.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang K, Weng H, Yang J, Wu C. Protective effect of Liuwei Dihuang Pill on cisplatin-induced reproductive toxicity and genotoxicity in male mice. J Ethnopharmacol. 2020;247:112269.

Article  CAS  PubMed  Google Scholar 

Nofal AE, Okdah YA, Rady MI, Hassaan HZ. Gum Acacia attenuates cisplatin toxic effect spermatogenesis dysfunction and infertility in rats. Int J Biol Macromol. 2023;240:124292.

Article  CAS  PubMed  Google Scholar 

Katanić Stanković JS, Selaković D, Rosić G. Oxidative damage as a fundament of systemic toxicities induced by cisplatin—the crucial limitation or potential therapeutic target? Int J Mol Sci. 2023;24(19):14574.

Article  PubMed  PubMed Central  Google Scholar 

Al Fayi M, Otifi H, Alshyarba M, Der AA, Rajagopalan P. Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling. J Drug Target. 2020;28(9):913–22.

Article  CAS  PubMed  Google Scholar 

Abd-Elkareem M, Abd El-Rahman MA, Khalil NSA, Amer AS. Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats. Sci Reports. 2021;11(1):13519.

CAS  Google Scholar 

Sadeghi E, Imenshahidi M, Hosseinzadeh H. Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review. Mol Biol Rep. 2023;50(6):5439–54.

Article  CAS  PubMed  Google Scholar 

Abdelbaky NW, Abdelazem AZ, Hashem KS. Thymoquinone attenuates 6-mercaptopurine induced testicular toxicity in albino rats: possible mechanisms are involved. Adv Anim Vet Sci. 2020;8(6):653–60.

Article  Google Scholar 

Gur FM, Timurkaan S, Taskin E, Guven C, Gur HE, Senturk M, Tatyuz I. Thymoquinone improves testicular damage and sperm quality in experimentally varicocele-induced adolescent rats. Andrologia. 2021;53(5):e14033.

Article  CAS  PubMed  Google Scholar 

Algaidi SA, Faddladdeen KA, Alrefaei GI, Qahl SH, Albadawi EA, Almohaimeed HM. Ayuob NN 2022 Thymoquinone protects the testes of hypothyroid rats by suppressing pro-inflammatory cytokines and oxidative stress and promoting SIRT1 testicular expression. Front Pharmacol. 2022;24(13):1040857.

Article  Google Scholar 

Mabrouk A. Therapeutic effect of thymoquinone against lead-induced testicular histological damage in male Wistar rats. Andrologia. 2018;50(6):e13014.

Article  CAS  PubMed  Google Scholar 

Salahshoor MR, Haghjoo M, Roshankhah S, Makalani F, Jalili C. Effect of thymoquinone on reproductive parameter in morphine-treated male mice. Adv Biomed Res. 2018;7:18.

Article  PubMed  PubMed Central  Google Scholar 

Hussein S, Kamel GAM. Pioglitazone ameliorates cisplatin-induced testicular toxicity by attenuating oxidative stress and inflammation via TLR4/MyD88/NF-κB signaling pathway. J Trace Elem Med Biol. 2023;80:127287.

Article  CAS  PubMed  Google Scholar 

Clague MJ, Urbé S, Komander D. Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function. Nat Rev Mol Cell Biol. 2019;20(5):321.

Article  CAS  PubMed  Google Scholar 

Verboom L, Hoste E, van Loo G. OTULIN in NF-κB signaling, cell death, and disease. Trends Immunol. 2021;42(7):590–603.

Article  CAS  PubMed  Google Scholar 

Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, Van Hove L, Voet S, Roels J, Maelfait J, Bongiovanni L, de Bruin A, Scott CL, Saeys Y, Pasparakis M, Bertrand MJM, van Loo G. OTULIN prevents liver ınflammation and hepatocellular carcinoma by ınhibiting fadd- and rıpk1 kinase-mediated hepatocyte apoptosis. Cell Rep. 2020;30(7):2237-224.e76.

Article  CAS  PubMed  Google Scholar 

Yalcın T, Kaya S, Kuloğlu T. Resveratrol may dose-dependently modulate nephrin and OTULIN levels in a doxorubicin-induced nephrotoxicity model. Toxicol Mech Methods. 2024;34(1):98–108.

Article  PubMed  Google Scholar 

Delanghe T, Dondelinger Y, Bertrand MJM. RIPK1 Kinase-Dependent Death: A symphony of phosphorylation events. Trends Cell Biol. 2020;30(3):189–200.

Article  CAS  PubMed  Google Scholar 

Kaya S, Yalcın T. In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics. Cell Stress Chaperones. 2023;28(6):811–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adana MY, Imam A, Bello AA, Sunmonu OE, Alege EP, Onigbolabi OG, Ajao MS. Oral thymoquinone modulates cyclophosphamide-induced testicular toxicity in adolescent Wistar rats. Andrologia. 2022;54(4): e14368.

Article  CAS  PubMed  Google Scholar 

Yalcın T, Kaya S. Thymoquinone may alleviate cisplatin-induced muscle atrophy in rats by regulating mitofusin 2 and meteorin-like levels. Comp Clin Pathol. 2023;32:339–45.

Article  Google Scholar 

Yalcın T, Kaya S, Kuloğlu T. N-acetylcysteine may regulate altered meteorin-like levels in testicular tissue due to aluminum exposure. Biol Trace Elem Res. 2023;201:5335–45.

Article  PubMed  Google Scholar 

Johnsen SG. Testicular biopsy score count–a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones. 1970;1(1):2–25.

CAS  PubMed  Google Scholar 

Kaya S, Yalçın T, Boydak M, Dönmez HH. Protective effect of N-acetylcysteine against aluminum-induced kidney tissue damage in rats. Biol Trace Elem Res. 2023;201(4):1806–15.

Article  CAS  PubMed  Google Scholar 

Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;7(72):248–54.

Article  Google Scholar 

Özdemir D, Saruhan S, Agca CA. KAN0438757: A novel PFKFB3 inhibitor that induces programmed cell death and suppresses cell migration in non-small cell lung carcinoma cells. Biotechnologia Acta. 2023;16(5):34–44.

Article  Google Scholar 

Cakmak R, Ay B, Çınar E, Başaran E, Akkoç S, Boğa M, Taş E. Synthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co (II), Ni (II), Cu (II), Zn (II), and Ru (III) complexes of pyrazolone-based Schiff base ligand. J Mol Struct. 2023;1292:136225.

Article  CAS  Google Scholar 

Barak S. Fertility preservation in male patients with cancer. Best Pract Res Clin Obstet Gynaecol. 2019;55:59–66.

Article  PubMed  Google Scholar 

Eren H, Mercantepe T, Tumkaya L, Mercantepe F, Dil E, Horsanali MO, Yilmaz A. Evaluation of the protective effects of amifostine and melatonin against cisplatin induced testis injury via oxidative stress and apoptosis in rats. Exp Mol Pathol. 2020;112:104324.

Article  CAS  PubMed  Google Scholar 

Zhang J, Fang Y, Tang D, Xu X, Zhu X, Wu S, Yu H, Cheng H, Luo T, Shen Q, Gao Y, Ma C, Liu Y, Wei Z, Chen X, Tao F, He X, Cao Y. Activation of MT1/MT2 to protect testes and leydig cells against cisplatin-induced oxidative stress through the SIRT1/Nrf2 signaling pathway. Cells. 2022;11(10):1690.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moradi Maryamneghari S, Shokri-Asl V, Abdolmaleki A, Jalili C. Genetic, biochemical and histopathological evaluations of thymoquinone on male reproduction system damaged by paclitaxel in Wistar rats. Andrologia. 2021;53(10):e14192.

Article  CAS  PubMed  Google Scholar 

Abdel-Daim MM, Abo El-Ela FI, Alshahrani FK, Bin-Jumah M, Al-Zharani M, Almutairi B, Alkahtani S. Protective effects of thymoquinone against acrylamide-induced liver, kidney and brain oxidative damage in rats. Environ Sci Pollut Res. 2020;27:37709–17.

Article  CAS  Google Scholar 

Ali BH, Al Za’abi M, Shalaby A, Manoj P, Waly MI, Yasin J, Fahim M, Nemmar A. The effect of thymoquinone treatment on the combined renal and pulmonary toxicity of cisplatin and diesel exhaust particles. Exp Biol Med (Maywood). 2015;240(12):1698–707.

Article  CAS  PubMed