Immunological Indicators of Recurrent Pregnancy Loss: A Mendelian Randomization Study

Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ. Recurrent pregnancy loss. Nat Rev Dis Primers. 2020;6(1):97.

Article  Google Scholar 

Bender Atik R, Christiansen OB, Elson J, Kolte AM, Lewis S, Middeldorp S, et al. ESHRE guideline: recurrent pregnancy loss. Hum Reprod Open. 2018;2018(2):hoy004.

Article  PubMed  PubMed Central  Google Scholar 

Bender Atik R, Christiansen OB, Elson J, Kolte AM, Lewis S, Middeldorp S, et al. ESHRE guideline: recurrent pregnancy loss: an update in 2022. Hum Reprod Open. 2023;2023(1):hoad002.

PubMed  PubMed Central  Google Scholar 

Rai R, Regan L. Recurrent miscarriage. Lancet (London England). 2006;368(9535):601–11.

Article  PubMed  Google Scholar 

Voss P, Schick M, Langer L, Ainsworth A, Ditzen B, Strowitzki T, et al. Recurrent pregnancy loss: a shared stressor—couple-orientated psychological research findings. Fertil Steril. 2020;114(6):1288–96.

Article  PubMed  Google Scholar 

Ferreira LMR, Meissner TB, Tilburgs T, Strominger JL. HLA-G: at the interface of maternal-fetal tolerance. Trends Immunol. 2017;38(4):272–86.

Article  CAS  PubMed  Google Scholar 

Wang W, Sung N, Gilman-Sachs A, Kwak-Kim JT. Helper (th) cell profiles in pregnancy and recurrent pregnancy losses: Th1/Th2/Th9/Th17/Th22/Tfh cells. Front Immunol. 2020;11:2025.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Granne I, Shen M, Rodriguez-Caro H, Chadha G, O’Donnell E, Brosens JJ, et al. Characterisation of peri-implantation endometrial Treg and identification of an altered phenotype in recurrent pregnancy loss. Mucosal Immunol. 2022;15(1):120–9.

Article  CAS  PubMed  Google Scholar 

McFadden JP, Thyssen JP, Basketter DA, Puangpet P, Kimber I. T helper cell 2 immune skewing in pregnancy/early life: chemical exposure and the development of atopic disease and allergy. Br J Dermatol. 2015;172(3):584–91.

Article  CAS  PubMed  Google Scholar 

Laird SM, Tuckerman EM, Cork BA, Linjawi S, Blakemore AIF, Li TC. A review of immune cells and molecules in women with recurrent miscarriage. Hum Reprod Update. 2003;9(2):163–74.

Article  CAS  PubMed  Google Scholar 

Comba C, Bastu E, Dural O, Yasa C, Keskin G, Ozsurmeli M et al. Role of inflammatory mediators in patients with recurrent pregnancy loss. Fertil Steril. 2015;104(6).

Abu-Ghazaleh N, Brennecke S, Murthi P, Karanam V. Association of vascular endothelial growth factors (VEGFs) with recurrent miscarriage: a systematic review of the literature. Int J Mol Sci. 2023;24(11).

Shakhar K, Rosenne E, Loewenthal R, Shakhar G, Carp H, Ben-Eliyahu S. High NK cell activity in recurrent miscarriage: what are we really measuring? Hum Reprod. 2006;21(9):2421–5.

Article  PubMed  Google Scholar 

Kwak JY, Beaman KD, Gilman-Sachs A, Ruiz JE, Schewitz D, Beer AE. Up-regulated expression of CD56+, CD56+/CD16+, and CD19 + cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am J Reprod Immunol. 1995;34(2):93–9.

Article  CAS  PubMed  Google Scholar 

Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, Chung-Bang H, Ng SC, Beaman KD, et al. Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod. 2001;16(5):855–61.

Article  CAS  PubMed  Google Scholar 

Ticconi C, Pietropolli A, Di Simone N, Piccione E, Fazleabas A. Endometrial immune dysfunction in recurrent pregnancy loss. Int J Mol Sci. 2019;20(21).

Larsson SC, Butterworth AS, Burgess S. Mendelian randomization for cardiovascular diseases: principles and applications. Eur Heart J. 2023;44(47):4913–24.

Article  PubMed  PubMed Central  Google Scholar 

Zhao J, Stewart ID, Baird D, Mason D, Wright J, Zheng J, et al. Causal effects of maternal circulating amino acids on offspring birthweight: a mendelian randomisation study. EBioMedicine. 2023;88:104441.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laisk T, Soares ALG, Ferreira T, Painter JN, Censin JC, Laber S, et al. The genetic architecture of sporadic and multiple consecutive miscarriage. Nat Commun. 2020;11(1):5980.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, et al. Genome-wide Association Study identifies 27 loci influencing concentrations of circulating cytokines and growth factors. Am J Hum Genet. 2017;100(1):40–50.

Article  CAS  PubMed  Google Scholar 

Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, et al. Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. Nat Genet. 2020;52(10):1036–45.

Article  PubMed  PubMed Central  Google Scholar 

Huang Y, Wang J, Yang H, Lin Z, Xu L. Causal associations between polyunsaturated fatty acids and kidney function: a bidirectional mendelian randomization study. Am J Clin Nutr. 2023;117(1):199–206.

Article  PubMed  Google Scholar 

Chen X, Kong J, Diao X, Cai J, Zheng J, Xie W, et al. Depression and prostate cancer risk: a mendelian randomization study. Cancer Med. 2020;9(23):9160–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilson R, Jenkins C, Miller H, McInnes IB, Moore J, McLean MA, et al. Abnormal cytokine levels in non-pregnant women with a history of recurrent miscarriage. Eur J Obstet Gynecol Reprod Biol. 2004;115(1):51–4.

Article  CAS  PubMed  Google Scholar 

Szereday L, Varga P, Szekeres-Bartho J. Cytokine production by lymphocytes in pregnancy. Am J Reprod Immunol. 1997;38(6):418–22.

Article  CAS  PubMed  Google Scholar 

Adib Rad H, Basirat Z, Mostafazadeh A, Faramarzi M, Bijani A, Nouri HR, et al. Evaluation of peripheral blood NK cell subsets and cytokines in unexplained recurrent miscarriage. J Chin Med Assoc. 2018;81(12):1065–70.

Article  PubMed  Google Scholar 

Zenclussen AC, Fest S, Busse P, Joachim R, Klapp BF, Arck PC. Questioning the Th1/Th2 paradigm in reproduction: peripheral levels of IL-12 are down-regulated in miscarriage patients. Am J Reprod Immunol. 2002;48(4):245–51.

Article  PubMed  Google Scholar 

Wu Y, Li Y, Zhu J, Long J. Shared genetics and causality underlying epilepsy and attention-deficit hyperactivity disorder. Psychiatry Res. 2022;316:114794.

Article  CAS  PubMed  Google Scholar 

Yeung CHC, Au Yeung SL, Kwok MK, Zhao JV, Schooling CM. The influence of growth and sex hormones on risk of alzheimer’s disease: a mendelian randomization study. Eur J Epidemiol. 2023;38(7):745–55.

Article  PubMed  Google Scholar 

Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003;3(2):133–46.

Article  CAS  PubMed  Google Scholar 

Watford WT, Moriguchi M, Morinobu A, O’Shea JJ. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev. 2003;14(5):361–8.

Article  CAS  PubMed  Google Scholar 

Lamptey J, Li F, Adu-Gyamfi EA, Chen X-M, Czika A, Otoo A, et al. Downregulation of fascin in the first trimester placental villi is associated with early recurrent miscarriage. Exp Cell Res. 2021;403(1):112597.

Article  CAS  PubMed  Google Scholar 

Pan T, Liu Y, Zhong LM, Shi MH, Duan XB, Wu K, et al. Myeloid-derived suppressor cells are essential for maintaining feto-maternal immunotolerance via STAT3 signaling in mice. J Leukoc Biol. 2016;100(3):499–511.

Article  CAS  PubMed  Google Scholar 

Li ZY, Chao HH, Liu HY, Song ZH, Li LL, Zhang YJ, et al. IFN-γ induces aberrant CD49b+ NK cell recruitment through regulating CX3CL1: a novel mechanism by which IFN-γ provokes pregnancy failure. Cell Death Dis. 2014;5(11):e1512.

Article  PubMed  PubMed Central  Google Scholar 

Arruvito L, Sotelo AI, Billordo A, Fainboim L. A physiological role for inducible FOXP3(+) Treg cells. Lessons from women with reproductive failure. Clin Immunol. 2010;136(3):432–41.

Article  CAS  PubMed  Google Scholar 

Zhu X, Liu H, Zhang Z, Wei R, Zhou X, Wang Z, et al. MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization. Int J Biol Sci. 2020;16(12):2248–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today. 1993;14(7):353–6.

Article  CAS  PubMed  Google Scholar 

Rugeles MT, Shearer GM. Alloantigen recognition in utero: dual advantage for the fetus? Trends Immunol. 2004;25(7):348–52.

Article  CAS  PubMed  Google Scholar 

Lim KJ, Odukoya OA, Ajjan RA, Li TC, Weetman AP, Cooke ID. The role of T-helper cytokines in human reproduction. Fertil Steril. 2000;73(1):136–42.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif