Impact of dehydroepiandrosterone sulfate and free androgen index on pregnancy and neonatal outcomes in PCOS patients

Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E, American association of clinical endocrinologists, american college of endocrinology, and androgen excess and pcos society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome. - PART 2. Endocr Pract. 2015;21(12):1415–26.

Article  PubMed  Google Scholar 

Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, Boyle J, Teede HJ. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668–80.

Article  CAS  PubMed  Google Scholar 

Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. J Clin Endocrinol Metab. 2006;91(11):4237–45.

Article  CAS  PubMed  Google Scholar 

Revised. 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004, 19(1):41–47.

Coskun A, Ercan O, Arikan DC, Özer A, Kilinc M, Kiran G, Kostu B. Modified Ferriman-Gallwey hirsutism score and androgen levels in Turkish women. Eur J Obstet Gynecol Reprod Biol. 2011;154(2):167–71.

Article  CAS  PubMed  Google Scholar 

Teede HJ, Tay CT, Laven J, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J. Recommendations from the 2023 International evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertil Steril. 2023;120(4):767–93.

Article  PubMed  Google Scholar 

Alesi S, Forslund M, Melin J, Romualdi D, Peña A, Tay CT, Witchel SF, Teede H, Mousa A. Efficacy and safety of anti-androgens in the management of polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials. EClinicalMedicine. 2023;63:102162.

Article  PubMed  PubMed Central  Google Scholar 

Kushnir VA, Darmon SK, Barad DH, Weghofer A, Gleicher N. Effects of dehydroepiandrosterone (DHEA) supplementation on sexual function in premenopausal infertile women. Endocrine. 2019;63(3):632–8.

Article  CAS  PubMed  Google Scholar 

Luque-Ramírez M, Escobar-Morreale HF. Adrenal hyperandrogenism and polycystic ovary syndrome. Curr Pharm Des. 2016;22(36):5588–602.

Article  PubMed  Google Scholar 

Turcu AF, Rege J, Auchus RJ, Rainey WE. 11-Oxygenated androgens in health and disease. Nat Rev Endocrinol. 2020;16(5):284–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan D, Shi J, Zhou H, Li N, Qu P. Predictive value of basal androgen levels on ongoing pregnancy rates during in vitro fertilization cycles. Gynecol Endocrinol. 2018;34(10):895–9.

Article  CAS  PubMed  Google Scholar 

Jiang LL, Pan P, Jiao XD, Qiu Q, Li Y, Zhang QX. [Effect of hyperandrogenism on pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer]. Zhonghua Yi Xue Za Zhi. 2023;103(14):1042–8.

CAS  PubMed  Google Scholar 

Rosato E, Sciarra F, Anastasiadou E, Lenzi A, Venneri MA. Revisiting the physiological role of androgens in women. Expert Rev Endocrinol Metab. 2022;17(6):547–61.

Article  CAS  PubMed  Google Scholar 

Herman T, Csehely S, Orosz M, Bhattoa HP, Deli T, Torok P, Lagana AS, Chiantera V, Jakab A. Impact of Endocrine disorders on IVF outcomes: results from a large, Single-Centre, prospective study. Reprod Sci. 2023;30(6):1878–90.

Article  CAS  PubMed  Google Scholar 

Zhang D, Gao J, Liu X, Qin H, Wu X. Effect of three androgen indexes (FAI, FT, and TT) on clinical, biochemical, and fertility outcomes in women with polycystic ovary syndrome. Reprod Sci. 2021;28(3):775–84.

Article  CAS  PubMed  Google Scholar 

Doi SA, Towers PA, Scott CJ, Al-Shoumer KA. PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic-pituitary-adrenal axis? Eur J Obstet Gynecol Reprod Biol. 2005;118(1):4–16.

Article  CAS  PubMed  Google Scholar 

Goodarzi MO, Carmina E, Azziz R. DHEA, DHEAS and PCOS. J Steroid Biochem Mol Biol. 2015;145:213–25.

Article  CAS  PubMed  Google Scholar 

Ma L, Cao Y, Ma Y, Zhai J. Association between hyperandrogenism and adverse pregnancy outcomes in patients with different polycystic ovary syndrome phenotypes undergoing in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis. Gynecol Endocrinol. 2021;37(8):694–701.

Article  CAS  PubMed  Google Scholar 

Lerchbaum E, Schwetz V, Giuliani A, Pieber TR, Obermayer-Pietsch B. Opposing effects of dehydroepiandrosterone sulfate and free testosterone on metabolic phenotype in women with polycystic ovary syndrome. Fertil Steril. 2012;98(5):1318–e13251311.

Article  CAS  PubMed  Google Scholar 

Zhou Z, Ni R, Hong Y, Li Y, Wang Y, Zhao X, Yang D. Defining hyperandrogenaemia according to the free androgen index in Chinese women: a cross-sectional study. Clin Endocrinol (Oxf). 2012;77(3):446–52.

Article  CAS  PubMed  Google Scholar 

Gonda KJ, Domar AD, Gleicher N, Marrs RP. Insights from clinical experience in treating IVF poor responders. Reprod Biomed Online. 2018;36(1):12–9.

Article  PubMed  Google Scholar 

Cummins JM, Breen TM, Harrison KL, Shaw JM, Wilson LM, Hennessey JF. A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J Vitro Fert Embryo Transf. 1986;3(5):284–95.

Article  CAS  Google Scholar 

Carmina E, Nasrallah MP, Guastella E, Lobo RA. Characterization of metabolic changes in the phenotypes of women with polycystic ovary syndrome in a large Mediterranean population from Sicily. Clin Endocrinol (Oxf). 2019;91(4):553–60.

Article  CAS  PubMed  Google Scholar 

Carmina E, Longo RA. Increased prevalence of Elevated DHEAS in PCOS Women with non-classic (B or C) phenotypes: a retrospective analysis in patients aged 20 to 29 years. Cells 2022, 11(20).

Carmina E, Rosato F, Jannì A. Increased DHEAs levels in PCO syndrome: evidence for the existence of two subgroups of patients. J Endocrinol Invest. 1986;9(1):5–9.

Article  CAS  PubMed  Google Scholar 

Esquivel-Zuniga MR, Kirschner CK, McCartney CR, Burt Solorzano CM. Non-PCOS Hyperandrogenic disorders in adolescents. Semin Reprod Med. 2022;40(1–02):42–52.

CAS  PubMed  Google Scholar 

Chen J, Wang Q, Pei Y, Li N, Han J, Yu J. Effect of free androgen index on blood pressure variability and target organ damage in postmenopausal hypertensive women: findings from a cross-sectional study. Menopause. 2021;28(11):1264–70.

Article  PubMed  PubMed Central  Google Scholar 

Rausch ME, Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, McGovern PG, Cataldo NA, et al. Predictors of pregnancy in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2009;94(9):3458–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin XF, Wu RR, Du J, Liao YC, Du Y, Ye Y, Wang Y, Zhang XB, Wu C, Chen A. Exploring the significance of sex hormone-binding globulin examination in the treament of women with polycystic ovarian syndrome (PCOS). Clin Exp Obstet Gynecol. 2015;42(3):315–20.

Article  CAS  PubMed  Google Scholar 

Kuang H, Jin S, Hansen KR, Diamond MP, Coutifaris C, Casson P, Christman G, Alvero R, Huang H, Bates GW, et al. Identification and replication of prediction models for ovulation, pregnancy and live birth in infertile women with polycystic ovary syndrome. Hum Reprod. 2015;30(9):2222–33.

Article  PubMed  PubMed Central  Google Scholar 

Joham AE, Boyle JA, Ranasinha S, Zoungas S, Teede HJ. Contraception use and pregnancy outcomes in women with polycystic ovary syndrome: data from the Australian longitudinal study on women’s Health. Hum Reprod. 2014;29(4):802–8.

Article  CAS  PubMed  Google Scholar 

Kim ST, Moley KH. Regulation of facilitative glucose transporters and AKT/MAPK/PRKAA signaling via estradiol and progesterone in the mouse uterine epithelium. Biol Reprod. 2009;81(1):188–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klinge CM, Clark BJ, Prough RA. Dehydroepiandrosterone Research: past, current, and Future. Vitam Horm. 2018;108:1–28.

Article  CAS  PubMed  Google Scholar 

Neves AR, Montoya-Botero P, Polyzos NP. Androgens and diminished ovarian reserve: the long road from basic science to clinical implementation. A comprehensive and systematic review with meta-analysis. Am J Obstet Gynecol. 2022;227(3):401–e413418.

Article  PubMed  Google Scholar 

Subirá J, Algaba A, Vázquez S, Taroncher Dasí R, Mollá Robles G, Monzó Fabuel S, Baydal V, Ruiz Herreros A. García Camuñas N, Rubio Rubio JM: Testosterone does not improve ovarian response in Bologna poor responders: a randomized controlled trial (TESTOPRIM). Reprod Biomed Online. 2021;43(3):466–74.

Article  PubMed  Google Scholar 

Medeiros SF, Barbosa BB, Medeiros MAS, Yamamoto A, Yamamoto MMW. Adrenal androgen Predictive effects on Clinical and metabolic abnormalities of polycystic ovary syndrome. Rev Bras Ginecol Obstet. 2022;44(2):142–53.

Article  PubMed  PubMed Central  Google Scholar 

de Medeiros SF, Barbosa BB, de Medeiros A, de Medeiros MAS, Yamamoto MMW. Differential effects of various androgens on polycystic ovary syndrome. Horm Metab Res. 2021;53(5):341–9.

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