Genistein alleviates dextran sulfate sodium-induced colitis in mice through modulation of intestinal microbiota and macrophage polarization

Wu Z, Huang S, Li T, Li N, Han D, Zhang B, Xu ZZ, Zhang S, Pang J, Wang S, Zhang G, Zhao J, Wang J (2021) Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis. Microbiome 9(1):184. https://doi.org/10.1186/s40168-021-01115-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG (2017) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 390(10114):2769–2778. https://doi.org/10.1016/S0140-6736(17)32448-0

Article  PubMed  Google Scholar 

Zhou X, Li W, Wang S, Zhang P, Wang Q, Xiao J, Zhang C, Zheng X, Xu X, Xue S, Hui L, Ji H, Wei B, Wang H (2019) YAP aggravates inflammatory Bowel Disease by regulating M1/M2 macrophage polarization and gut microbial homeostasis. Cell Rep 27(4):1176–1189e1175. https://doi.org/10.1016/j.celrep.2019.03.028

Article  CAS  PubMed  Google Scholar 

Wu MN, Li PZ, An YY, Ren J, Yan D, Cui JZ, Li D, Li M, Wang MY, Zhong GS (2019) Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota. Pharmacol Res 150. https://doi.org/10.1016/j.phrs.2019.104489

Kobayashi T, Siegmund B, Le Berre C, Wei SC, Ferrante M, Shen B, Bernstein CN, Danese S, Peyrin-Biroulet L, Hibi T (2020) Ulcerative colitis. Nat Rev Dis Primers 6(1):74. https://doi.org/10.1038/s41572-020-0205-x

Article  PubMed  Google Scholar 

Liang L, Yang C, Liu L, Mai G, Li H, Wu L, Jin M, Chen Y (2022) Commensal bacteria-derived extracellular vesicles suppress ulcerative colitis through regulating the macrophages polarization and remodeling the gut microbiota. Microb Cell Fact 21(1):88. https://doi.org/10.1186/s12934-022-01812-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D (2015) Role of the normal gut microbiota. World J Gastroenterol 21(29):8787–8803. https://doi.org/10.3748/wjg.v21.i29.8787

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stephens M, von der Weid PY (2020) Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner. Gut Microbes 11(3):421–432. https://doi.org/10.1080/19490976.2019.1629235

Article  CAS  PubMed  Google Scholar 

Moreira Lopes TC, Mosser DM, Goncalves R (2020) Macrophage polarization in intestinal inflammation and gut homeostasis. Inflamm Res 69(12):1163–1172. https://doi.org/10.1007/s00011-020-01398-y

Article  CAS  PubMed  Google Scholar 

Vannella KM, Wynn TA (2017) Mechanisms of Organ Injury and Repair by macrophages. Annu Rev Physiol 79:593–617. https://doi.org/10.1146/annurev-physiol-022516-034356

Article  CAS  PubMed  Google Scholar 

Yang Z, Lin S, Feng W, Liu Y, Song Z, Pan G, Zhang Y, Dai X, Ding X, Chen L, Wang Y (2022) A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: macrophage polarization. Front Pharmacol 13:999179. https://doi.org/10.3389/fphar.2022.999179

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang L, Liu L, Zhou W, Yang C, Mai G, Li H, Chen Y (2022) Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway. Clin Sci (Lond) 136(4):291–307. https://doi.org/10.1042/CS20210778

Article  CAS  PubMed  Google Scholar 

Li X, Cui L, Feng G, Yu S, Shao G, He N, Li S (2022) Collagen peptide promotes DSS-induced colitis by disturbing gut microbiota and regulation of macrophage polarization. Front Nutr 9:957391. https://doi.org/10.3389/fnut.2022.957391

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang R, Jia Q, Liu XF, Ma SF (2018) Effect of genistein on myocardial fibrosis in diabetic rats and its mechanism. Mol Med Rep 17(2):2929–2936. https://doi.org/10.3892/mmr.2017.8268

Article  CAS  PubMed  Google Scholar 

Mukund V, Mukund D, Sharma V, Mannarapu M, Alam A (2017) Genistein: its role in metabolic diseases and cancer. Crit Rev Oncol Hematol 119:13–22. https://doi.org/10.1016/j.critrevonc.2017.09.004

Article  PubMed  Google Scholar 

Gupta SK, Dongare S, Mathur R, Mohanty IR, Srivastava S, Mathur S, Nag TC (2015) Genistein ameliorates cardiac inflammation and oxidative stress in streptozotocin-induced diabetic cardiomyopathy in rats. Mol Cell Biochem 408(1–2):63–72. https://doi.org/10.1007/s11010-015-2483-2

Article  CAS  PubMed  Google Scholar 

Li S, Zhou L, Zhang Q, Yu M, Xiao X (2022) Genistein improves glucose metabolism and promotes adipose tissue browning through modulating gut microbiota in mice. Food Funct 13(22):11715–11732. https://doi.org/10.1039/d2fo01973f

Article  CAS  PubMed  Google Scholar 

Yang R, Jia Q, Mehmood S, Ma S, Liu X (2021) Genistein ameliorates inflammation and insulin resistance through mediation of gut microbiota composition in type 2 diabetic mice. Eur J Nutr 60(4):2155–2168. https://doi.org/10.1007/s00394-020-02403-0

Article  CAS  PubMed  Google Scholar 

Chen Y, Le TH, Du Q, Zhao Z, Liu Y, Zou J, Hua W, Liu C, Zhu Y (2019) Genistein protects against DSS-induced colitis by inhibiting NLRP3 inflammasome via TGR5-cAMP signaling. Int Immunopharmacol 71:144–154. https://doi.org/10.1016/j.intimp.2019.01.021

Article  CAS  PubMed  Google Scholar 

Lv Q, Xing Y, Liu J, Dong D, Liu Y, Qiao H, Zhang Y, Hu L (2021) Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation. Acta Pharm Sin B 11(9):2880–2899. https://doi.org/10.1016/j.apsb.2021.03.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang R, Jia Q, Ma SF, Wang Y, Mehmood S, Chen Y (2019) Exogenous H2S mitigates myocardial fibrosis in diabetic rats through suppression of the canonical wnt pathway. Int J Mol Med 44(2):549–558. https://doi.org/10.3892/ijmm.2019.4237

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang R, Li Y, Mehmood S, Yan C, Huang Y, Cai J, Ji J, Pan W, Zhang W, Chen Y (2020) Polysaccharides from Armillariella tabescens mycelia ameliorate renal damage in type 2 diabetic mice. Int J Biol Macromol 162:1682–1691. https://doi.org/10.1016/j.ijbiomac.2020.08.006

Article  CAS  PubMed  Google Scholar 

Sun J, Furio L, Mecheri R, van der Does AM, Lundeberg E, Saveanu L, Chen Y, van Endert P, Agerberth B, Diana J (2015) Pancreatic beta-cells limit Autoimmune Diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota. Immunity 43(2):304–317. https://doi.org/10.1016/j.immuni.2015.07.013

Article  CAS  PubMed  Google Scholar 

Birchenough GM, Nystrom EE, Johansson ME, Hansson GC (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352(6293):1535–1542. https://doi.org/10.1126/science.aaf7419

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang R, Wang Y, Mehmood S, Zhao M, Yang X, Li Y, Wang W, Chen J, Jia Q (2023) Polysaccharides from Armillariella tabescens mycelia mitigate DSS-induced ulcerative colitis via modulating intestinal microbiota in mice. Int J Biol Macromol 245:125538. https://doi.org/10.1016/j.ijbiomac.2023.125538

Article  CAS  PubMed  Google Scholar 

Su L, Li D, Su J, Zhang E, Chen S, Zheng C, Luo T, Li M, Chen X, Huang G, Xie Y, Li S (2021) Polysaccharides of Sporoderm-Broken Spore of Ganoderma lucidum Modulate Adaptive Immune Function via Gut Microbiota Regulation. Evid Based Complement Alternat Med 2021:8842062. https://doi.org/10.1155/2021/8842062

Wang Y, Liu J, Huang Z, Li Y, Liang Y, Luo C, Ni C, Xie J, Su Z, Chen J, Li C (2021) Coptisine ameliorates DSS-induced ulcerative colitis via improving intestinal barrier dysfunction and suppressing inflammatory response. Eur J Pharmacol 896:173912. https://doi.org/10.1016/j.ejphar.2021.173912

Article  CAS  PubMed  Google Scholar 

Li B, Du P, Du Y, Zhao D, Cai Y, Yang Q, Guo Z (2021) Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats. Life Sci 269:119008. https://doi.org/10.1016/j.lfs.2020.119008

Article  CAS  PubMed  Google Scholar 

Hine AM, Loke P (2019) Intestinal macrophages in resolving inflammation. J Immunol 203(3):593–599. https://doi.org/10.4049/jimmunol.1900345

Article  CAS  PubMed  Google Scholar 

Sica A, Erreni M, Allavena P, Porta C (2015) Macrophage polarization in pathology. Cell Mol Life Sci 72(21):4111–4126. https://doi.org/10.1007/s00018-015-1995-y

Article  CAS  PubMed  Google Scholar 

Hirschberg S, Gisevius B, Duscha A, Haghikia A (2019) Implications of Diet and the gut Microbiome in Neuroinflammatory and neurodegenerative diseases. Int J Mol Sci 20(12). https://doi.org/10.3390/ijms20123109

Wang Z, Zhang X, Zhu L, Yang X, He F, Wang T, Bao T, Lu H, Wang H, Yang S (2020) Inulin alleviates inflammation of alcoholic liver disease via SCFAs-inducing suppression of M1 and facilitation of M2 macrophages in mice. Int Immunopharmacol 78:106062. https://doi.org/10.1016/j.intimp.2019.106062

Article  CAS  PubMed  Google Scholar 

Blaak EE, Canfora EE, Theis S, Frost G, Groen AK, Mithieux G, Nauta A, Scott K, Stahl B, van Harsselaar J, van Tol R, Vaughan EE, Verbeke K (2020) Short chain fatty acids in human gut and metabolic health. Benef Microbes 11(5):411–455. https://doi.org/10.3920/BM2020.0057

Article  CAS 

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