Boucret L, ChaodelaBarca JM, Morinière C, Desquiret V, Ferré-L’Hôtellier V, Descamps P, et al. Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells. Human reproduction (Oxford England). 2015;30(7):1653–64.

Article  CAS  PubMed  Google Scholar 

Ganer Herman H, Volodarsky-Perel A, Ton Nu TN, Machado-Gedeon A, Cui Y, Shaul J, et al. Diminished ovarian reserve is a risk factor for preeclampsia and placental malperfusion lesions. Fertil Steril. 2023;119(5):794–801.

Article  PubMed  Google Scholar 

Busnelli A, Somigliana E, Cirillo F, Levi-Setti PE. Is diminished ovarian reserve a risk factor for miscarriage? Results of a systematic review and meta-analysis. Hum Reprod Update. 2021;27(6):973–88.

Article  PubMed  Google Scholar 

Haas J, Casper RF. In vitro fertilization treatments with the use of clomiphene citrate or letrozole. Fertil Steril. 2017;108(4):568–71.

Article  CAS  PubMed  Google Scholar 

Lin HT, Wu MH, Tsai LC, Chen TS, Ou HT. Co-Administration of Clomiphene Citrate and Letrozole in Mild Ovarian Stimulation Versus Conventional Controlled Ovarian Stimulation Among POSEIDON Group 4 Patients. Front Endocrinol (Lausanne). 2021;12: 780392.

Article  PubMed  Google Scholar 

Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, et al. The International Glossary on Infertility and Fertility Care, 2017. Human reproduction (Oxford, England). 2017;32(9):1786–801.

Article  PubMed  Google Scholar 

Hershko Klement A, Shulman A. hCG Triggering in ART: An Evolutionary Concept. Int J Mol Sci. 2017;18(5):1075.

Humaidan P, Polyzos NP, Alsbjerg B, Erb K, Mikkelsen AL, Elbaek HO, et al. GnRHa trigger and individualized luteal phase hCG support according to ovarian response to stimulation: two prospective randomized controlled multi-centre studies in IVF patients. Human reproduction (Oxford, England). 2013;28(9):2511–21.

Article  CAS  PubMed  Google Scholar 

Hsia LH, Lee TH, Lin YH, Huang YY, Chang HJ, Liu YL. Dual trigger improves the pregnancy rate in fresh in vitro fertilization (IVF) cycles compared with the human chorionic gonadotropin (hCG) trigger: a systematic review and meta-analysis of randomized trials. J Assist Reprod Genet. 2023;40(9):2063–77.

Article  PubMed  Google Scholar 

Zhou C, Yang X, Wang Y, Xi J, Pan H, Wang M, et al. Ovulation triggering with hCG alone, GnRH agonist alone or in combination? A randomized controlled trial in advanced-age women undergoing IVF/ICSI cycles. Human reproduction (Oxford, England). 2022;37(8):1795–805.

Article  CAS  PubMed  Google Scholar 

Eftekhar M, Mojtahedi MF, Miraj S, Omid M. Final follicular maturation by administration of GnRH agonist plus HCG versus HCG in normal responders in ART cycles: An RCT. International journal of reproductive biomedicine. 2017;15(7):429–34.

CAS  PubMed  PubMed Central  Google Scholar 

Haas J, Bassil R, Samara N, Zilberberg E, Mehta C, Orvieto R, et al. GnRH agonist and hCG (dual trigger) versus hCG trigger for final follicular maturation: a double-blinded, randomized controlled study. Human reproduction (Oxford, England). 2020;35(7):1648–54.

Article  CAS  PubMed  Google Scholar 

Zhou X, Guo P, Chen X, Ye D, Liu Y, Chen S. Comparison of dual trigger with combination GnRH agonist and hCG versus hCG alone trigger of oocyte maturation for normal ovarian responders. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2018;141(3):327–31.

Article  CAS  PubMed  Google Scholar 

Lin MH, Wu FS, Hwu YM, Lee RK, Li RS, Li SH. Dual trigger with gonadotropin releasing hormone agonist and human chorionic gonadotropin significantly improves live birth rate for women with diminished ovarian reserve. Reprod Biol Endocrinol. 2019;17(1):7.

Article  PubMed  PubMed Central  Google Scholar 

Chern CU, Li JY, Tsui KH, Wang PH, Wen ZH, Lin LT. Dual-trigger improves the outcomes of in vitro fertilization cycles in older patients with diminished ovarian reserve: A retrospective cohort study. PLoS ONE. 2020;15(7): e0235707.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong YH, Kim SK, Lee JR, Jee BC, Suh CS. Clinical efficacy of dual trigger with human chorionic gonadotropin and a gonadotropin-releasing hormone agonist for women undergoing fertility preservation. Reproductive medicine and biology. 2022;21(1): e12440.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ren YM, Wang YB, Fu M, Zhang QX, Shen H, Han HJ, et al. Effect of Dual Trigger In Vitro Fertilization and Intracytoplasmic Sperm Injection During the Gonadotropin-releasing Hormone-Antagonist Cycle on Final Oocyte Maturation and Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve. Current medical science. 2022;42(5):1066–70.

Article  CAS  PubMed  Google Scholar 

Jaswa EG, McCulloch CE, Simbulan R, Cedars MI, Rosen MP. Diminished ovarian reserve is associated with reduced euploid rates via preimplantation genetic testing for aneuploidy independently from age: evidence for concomitant reduction in oocyte quality with quantity. Fertil Steril. 2021;115(4):966–73.

Article  CAS  PubMed  Google Scholar 

Xu Y, Nisenblat V, Lu C, Li R, Qiao J, Zhen X, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018;16(1):29.

Article  PubMed  PubMed Central  Google Scholar 

Schachter M, Friedler S, Ron-El R, Zimmerman AL, Strassburger D, Bern O, et al. Can pregnancy rate be improved in gonadotropin-releasing hormone (GnRH) antagonist cycles by administering GnRH agonist before oocyte retrieval? A prospective, randomized study. Fertil Steril. 2008;90(4):1087–93.

Article  CAS  PubMed  Google Scholar 

Humaidan P, Papanikolaou EG, Tarlatzis BC. GnRHa to trigger final oocyte maturation: a time to reconsider. Human reproduction (Oxford, England). 2009;24(10):2389–94.

Article  CAS  PubMed  Google Scholar 

Zhu H, Zhao C, Pan Y, Zhou H, Jin X, Xu W, et al. Dual Trigger for Final Follicular Maturation Improves Cumulative Live-Birth Rate in Ovarian Stimulation for Freeze-All In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles. Front Endocrinol (Lausanne). 2021;12: 708247.

Article  PubMed  Google Scholar 

Haas J, Ophir L, Barzilay E, Machtinger R, Yung Y, Orvieto R, et al. Standard human chorionic gonadotropin versus double trigger for final oocyte maturation results in different granulosa cells gene expressions: a pilot study. Fertil Steril. 2016;106(3):653-9.e1.

Article  CAS  PubMed  Google Scholar 

Light A, Hammes SR. LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands. Biol Reprod. 2015;93(3):65.

Article  PubMed  PubMed Central  Google Scholar 

Poulsen LC, Bøtkjær JA, Østrup O, Petersen KB, Andersen CY, Grøndahl ML, et al. Two waves of transcriptomic changes in periovulatory human granulosa cells. Human reproduction (Oxford, England). 2020;35(5):1230–45.

Article  CAS  PubMed  Google Scholar 

Oliveira JB, Baruffi R, Petersen CG, Mauri AL, Cavagna M, Franco JG Jr. Administration of single-dose GnRH agonist in the luteal phase in ICSI cycles: a meta-analysis. Reprod Biol Endocrinol. 2010;8:107.

Article  PubMed  PubMed Central  Google Scholar 

Oron G, Sapir O, Shufaro Y, Wertheimer A, Ben-Haroush A. Effect of the co-administration of HCG and GnRH agonist (dual trigger) versus standard HCG trigger on morphokinetic embryo parameters. Reprod Biomed Online. 2022;45(4):696–702.

Article  CAS  PubMed  Google Scholar 

Xu DF, Liu PP, Fan L, Xie Q, Zhang ZQ, Wang LQ, et al. GnRH antagonist weakens endometrial stromal cells growth ability by decreasing c-kit receptor expression. Reprod Biol Endocrinol. 2022;20(1):29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chou CS, MacCalman CD, Leung PC. Differential effects of gonadotropin-releasing hormone I and II on the urokinase-type plasminogen activator/plasminogen activator inhibitor system in human decidual stromal cells in vitro. J Clin Endocrinol Metab. 2003;88(8):3806–15.

Article  CAS  PubMed  Google Scholar