Lee JH, Lee JE, Kahng JY, Kim SH, Park JS, Yoon SJ, et al. Human glioblastoma arises from subventricular zone cells with low-level driver mutations. Nature. 2018;560:243–7. https://doi.org/10.1038/s41586-018-0389-3
Article CAS PubMed Google Scholar
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro-Oncol. 2021;23:1231–51. https://doi.org/10.1093/neuonc/noab106
Article CAS PubMed PubMed Central Google Scholar
Zur Hausen H. Cancers in humans: a lifelong search for contributions of infectious agents, autobiographic Notes. Annu Rev Virol. 2019;6:1–28. https://doi.org/10.1146/annurev-virology-092818-015907
Article CAS PubMed Google Scholar
El Baba R, Herbein G. Immune landscape of CMV infection in cancer patients: from “canonical” diseases toward virus-elicited oncomodulation. Front Immunol. 2021;12:730765. https://doi.org/10.3389/fimmu.2021.730765
Article CAS PubMed PubMed Central Google Scholar
Geder L, Sanford EJ, Rohner TJ, Rapp F. Cytomegalovirus and cancer of the prostate: in vitro transformation of human cells. Cancer Treat Rep. 1977;61:139–46.
Cobbs C, Harkins L, Samanta M, Gillespie G, Bharara S, King P, et al. Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res. 2002;62:3347–50.
Kumar A, Tripathy MK, Pasquereau S, Al Moussawi F, Abbas W, Coquard L, et al. The human cytomegalovirus strain DB activates oncogenic pathways in mammary epithelial cells. EBioMedicine. 2018;30:167–83. https://doi.org/10.1016/j.ebiom.2018.03.015
Article CAS PubMed PubMed Central Google Scholar
Herbein G. The human cytomegalovirus, from oncomodulation to oncogenesis. Viruses. 2018;10:408. https://doi.org/10.3390/v10080408
Article CAS PubMed PubMed Central Google Scholar
El Baba R, Pasquereau S, Haidar Ahmad S, Monnien F, Abad M, Bibeau F, et al. EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes. Oncogene. 2023;42:2031–45. https://doi.org/10.1038/s41388-023-02709-3
Article CAS PubMed PubMed Central Google Scholar
El Baba R, Haidar Ahmad S, Monnien F, Mansar R, Bibeau F, Herbein G. Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells. Oncogene. 2023;42:3047–61. https://doi.org/10.1038/s41388-023-02813-4
Article CAS PubMed PubMed Central Google Scholar
Bouezzedine F, El Baba R, Haidar Ahmad S, Herbein G. Polyploid giant cancer cells generated from human cytomegalovirus-infected prostate epithelial cells. Cancers. 2023;15:4994. https://doi.org/10.3390/cancers15204994
Article CAS PubMed PubMed Central Google Scholar
Belzile J-P, Stark TJ, Yeo GW, Spector DH. Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA. J Virol. 2014;88:4021–39. https://doi.org/10.1128/JVI.03492-13
Article CAS PubMed PubMed Central Google Scholar
Odeberg J, Wolmer N, Falci S, Westgren M, Seiger Å, Söderberg-Nauclér C. Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cells. J Virol. 2006;80:8929–39. https://doi.org/10.1128/JVI.00676-06
Article CAS PubMed PubMed Central Google Scholar
Kossmann T, Morganti‐Kossmann MC, Orenstein JM, Britt WJ, Wahl SM, Smith PD. Cytomegalovirus production by infected astrocytes correlates with transforming growth factor‐β Release. J INFECT DIS. 2003;187:534–41. https://doi.org/10.1086/373995
Article CAS PubMed Google Scholar
Luo MH, Hannemann H, Kulkarni AS, Schwartz PH, O’Dowd JM, Fortunato EA. Human cytomegalovirus infection causes premature and abnormal differentiation of human neural progenitor cells. J Virol. 2010;84:3528–41. https://doi.org/10.1128/JVI.02161-09
Article CAS PubMed PubMed Central Google Scholar
Geder L, Lausch R, O’Neill F, Rapp F. Oncogenic transformation of human embryo lung cells by human cytomegalovirus. Science. 1976;192:1134–7. https://doi.org/10.1126/science.179143
Article CAS PubMed Google Scholar
Nehme Z, Pasquereau S, Haidar Ahmad S, Coaquette A, Molimard C, Monnien F, et al. Polyploid giant cancer cells, stemness and epithelial-mesenchymal plasticity elicited by human cytomegalovirus. Oncogene. 2021;40:3030–46. https://doi.org/10.1038/s41388-021-01715-7
Article CAS PubMed Google Scholar
Arrieta VA, Dmello C, McGrail DJ, Brat DJ, Lee-Chang C, Heimberger AB, et al. Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment. J Clin Investig. 2023;133:e163447. https://doi.org/10.1172/JCI163447
Article CAS PubMed PubMed Central Google Scholar
Pantalone MR, Rahbar A, Söderberg-Naucler C, Stragliotto G. Valganciclovir as add-on to second-line therapy in patients with recurrent glioblastoma. Cancers. 2022;14:1958. https://doi.org/10.3390/cancers14081958
Article CAS PubMed PubMed Central Google Scholar
Daubon T, Hemadou A, Romero Garmendia I, Saleh M. Glioblastoma immune landscape and the potential of new immunotherapies. Front Immunol. 2020;11:585616. https://doi.org/10.3389/fimmu.2020.585616
Article CAS PubMed PubMed Central Google Scholar
Schuessler A, Smith C, Beagley L, Boyle GM, Rehan S, Matthews K, et al. Autologous T-cell therapy for cytomegalovirus as a consolidative treatment for recurrent glioblastoma. Cancer Res. 2014;74:3466–76. https://doi.org/10.1158/0008-5472.CAN-14-0296
Article CAS PubMed Google Scholar
Alcaniz J, Winkler L, Dahlmann M, Becker M, Orthmann A, Haybaeck J, et al. Clinically relevant glioblastoma patient-derived xenograft models to guide drug development and identify molecular signatures. Front Oncol. 2023;13:1129627. https://doi.org/10.3389/fonc.2023.1129627
Article CAS PubMed PubMed Central Google Scholar
Rossetto CC, Tarrant-Elorza M, Pari GS. Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) Monocytes and CD34 (+) Cells. PLoS Pathog. 2013;9:e1003366. https://doi.org/10.1371/journal.ppat.1003366
Article CAS PubMed PubMed Central Google Scholar
Nehme Z, Pasquereau S, Haidar Ahmad S, El Baba R, Herbein G. Polyploid giant cancer cells, EZH2 and Myc upregulation in mammary epithelial cells infected with high-risk human cytomegalovirus. eBioMedicine. 2022;80:104056. https://doi.org/10.1016/j.ebiom.2022.104056
Article CAS PubMed PubMed Central Google Scholar
Battistelli C, Cicchini C, Santangelo L, Tramontano A, Grassi L, Gonzalez FJ, et al. The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition. Oncogene. 2017;36:942–55. https://doi.org/10.1038/onc.2016.260
Article CAS PubMed Google Scholar
Haidar Ahmad S, Pasquereau S, El Baba R, Nehme Z, Lewandowski C, Herbein G. Distinct oncogenic transcriptomes in human mammary epithelial cells infected with cytomegalovirus. Front Immunol. 2021;12:772160. https://doi.org/10.3389/fimmu.2021.772160
Article CAS PubMed PubMed Central Google Scholar
Daubon T, Guyon J, Raymond A-A, Dartigues B, Rudewicz J, Ezzoukhry Z, et al. The invasive proteome of glioblastoma revealed by laser-capture microdissection. Neuro-Oncol Adv. 2019;1:vdz029. https://doi.org/10.1093/noajnl/vdz029
Guyon J, Andrique L, Pujol N, Røsland GV, Recher G, Bikfalvi A, et al. A 3D Spheroid Model for Glioblastoma. JoVE:60998. https://doi.org/10.3791/60998 (2020).
Bougnaud S, Golebiewska A, Oudin A, Keunen O, Harter PN, Mäder L, et al. Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma. Oncotarget. 2016;7:31955–71. https://doi.org/10.18632/oncotarget.7454
Article PubMed PubMed Central Google Scholar
Daubon T, Léon C, Clarke K, Andrique L, Salabert L, Darbo E, et al. Deciphering the complex role of thrombospondin-1 in glioblastoma development. Nat Commun. 2019;10:1146. https://doi.org/10.1038/s41467-019-08480-y
Article CAS PubMed PubMed Central Google Scholar
Khan KA, Coaquette A, Davrinche C, Herbein G. Bcl-3-regulated transcription from major immediate-early promoter of human cytomegalovirus in monocyte-derived macrophages. J Immunol. 2009;182:7784–94. https://doi.org/10.4049/jimmunol.0803800
Article CAS PubMed Google Scholar
Chen X, Guo Z-Q, Cao D, Chen Y, Chen J. MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1/FAK/Akt signaling. Cell Death Dis. 2021;12:244. https://doi.org/10.1038/s41419-021-03532-y
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