SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer

Robert C. A decade of immune-checkpoint inhibitors in cancer therapy. Nat Commun. 2020;11:3801.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Chen EX, Jonker DJ, Loree JM, Kennecke HF, Berry SR, Couture F, et al. Effect of combined immune checkpoint inhibition vs best supportive care alone in patients with advanced colorectal cancer: the Canadian Cancer Trials Group CO.26 Study. JAMA Oncol. 2020;6:831–8.

Article  PubMed  Google Scholar 

Vilar E, Gruber SB. Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol. 2010;7:153–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2023;34:10–32.

Article  CAS  PubMed  Google Scholar 

Zhang H, Liu L, Liu J, Dang P, Hu S, Yuan W, et al. Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers. Mol Cancer. 2023;22:58.

Article  PubMed  PubMed Central  Google Scholar 

Raskov H, Orhan A, Gaggar S, Gögenur I. Cancer-associated fibroblasts and tumor-associated macrophages in cancer and cancer immunotherapy. Front Oncol. 2021;11:668731.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol. 2009;27:451–83.

Article  CAS  PubMed  Google Scholar 

Krneta T, Gillgrass A, Poznanski S, Chew M, Lee AJ, Kolb M, et al. M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner. J Leukoc Biol. 2017;101:285–95.

Article  CAS  PubMed  Google Scholar 

Molgora M, Esaulova E, Vermi W, Hou J, Chen Y, Luo J, et al. TREM2 modulation remodels the tumor myeloid landscape enhancing anti-PD-1 immunotherapy. Cell. 2020;182:886–900.e17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi L, Wang J, Ding N, Zhang Y, Zhu Y, Dong S, et al. Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy. Nat Commun. 2019;10:5421.

Article  PubMed  PubMed Central  Google Scholar 

Fang DD, Tang Q, Kong Y, Wang Q, Gu J, Fang X, et al. MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment. J Immunother Cancer. 2019;7:327.

Article  PubMed  PubMed Central  Google Scholar 

Pradhan AK, Maji S, Das SK, Emdad L, Sarkar D, Fisher PB. MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein. Cancer Metastasis Rev. 2020;39:769–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das SK, Maji S, Wechman SL, Bhoopathi P, Pradhan AK, Talukdar S, et al. MDA-9/Syntenin (SDCBP): novel gene and therapeutic target for cancer metastasis. Pharm Res. 2020;155:104695.

Article  CAS  Google Scholar 

Boukerche H, Su Z-z, Emdad L, Sarkar D, Fisher PB. mda-9/Syntenin regulates the metastatic phenotype in human melanoma cells by activating nuclear factor-kappaB. Cancer Res. 2007;67:1812–22.

Article  CAS  PubMed  Google Scholar 

Hwangbo C, Kim J, Lee JJ, Lee J-H. Activation of the integrin effector kinase focal adhesion kinase in cancer cells is regulated by crosstalk between protein kinase Calpha and the PDZ adapter protein mda-9/Syntenin. Cancer Res. 2010;70:1645–55.

Article  CAS  PubMed  Google Scholar 

Das SK, Pradhan AK, Bhoopathi P, Talukdar S, Shen X-N, Sarkar D, et al. The MDA-9/syntenin/IGF1R/STAT3 axis directs prostate cancer invasion. Cancer Res. 2018;78:2852–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iwamoto K, Takahashi H, Okuzaki D, Osawa H, Ogino T, Miyoshi N, et al. Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor. Br J Cancer. 2020;123:955–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamura K, Ikutani M, Yoshida T, Tanaka-Hayashi A, Yanagibashi T, Inoue R, et al. Increased production of intestinal immunoglobulins in Syntenin-1-deficient mice. Immunobiology. 2015;220:597–604.

Article  CAS  PubMed  Google Scholar 

Liu J, Bai W, Zhou T, Xie Y, Yang B, Sun J, et al. SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation. Gut. 2023;72:1722–37.

Article  CAS  PubMed  Google Scholar 

Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, et al. Integrin CD11b activation drives anti-tumor innate immunity. Nat Commun. 2018;9:5379.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ganesh K, Stadler ZK, Cercek A, Mendelsohn RB, Shia J, Segal NH, et al. Immunotherapy in colorectal cancer: rationale, challenges and potential. Nat Rev Gastroenterol Hepatol. 2019;16:361–75.

Article  PubMed  PubMed Central  Google Scholar 

Talukdar S, Das SK, Pradhan AK, Emdad L, Windle JJ, Sarkar D, et al. MDA-9/syntenin (SDCBP) is a critical regulator of chemoresistance, survival and stemness in prostate cancer stem cells. Cancers. 2019;12:53.

Article  PubMed  PubMed Central  Google Scholar 

Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, et al. Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker. Nat Cell Biol. 2021;23:631–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarkar D, Boukerche H, Su Z-Z, Fisher PB. mda-9/Syntenin: more than just a simple adapter protein when it comes to cancer metastasis. Cancer Res. 2008;68:3087–93.

Article  CAS  PubMed  Google Scholar 

Liu J, Yang Y, Wang H, Wang B, Zhao K, Jiang W, et al. Syntenin1/MDA-9 (SDCBP) induces immune evasion in triple-negative breast cancer by upregulating PD-L1. Breast Cancer Res Treat. 2018;171:345–57.

Article  CAS  PubMed  Google Scholar 

Li Y, Huang W, Fang S, Li Z, Li Z, Wang F, et al. Zinc pyrithione induced volatile fatty acids promotion derived from sludge anaerobic digestion: Interrelating the affected steps with microbial metabolic regulation and adaptive responses. Water Res. 2023;234:119816.

Article  CAS  PubMed  Google Scholar 

Tailler M, Senovilla L, Lainey E, Thépot S, Métivier D, Sébert M, et al. Antineoplastic activity of ouabain and pyrithione zinc in acute myeloid leukemia. Oncogene. 2012;31:3536–46.

Article  CAS  PubMed  Google Scholar 

Srivastava G, Matta A, Fu G, Somasundaram RT, Datti A, Walfish PG, et al. Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy. Mol Oncol. 2015;9:1720–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rudolf E, Cervinka M. Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes. Biometals. 2010;23:339–54.

Article  CAS  PubMed  Google Scholar 

Hashemi M, Ghavami S, Eshraghi M, Booy EP, Los M. Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells. Eur J Pharm. 2007;557:9–19.

Article  CAS  Google Scholar 

Carraway RE, Dobner PR. Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells. Biochim Biophys Acta. 2012;1823:544–57.

Article  CAS  PubMed  Google Scholar 

Gajewski TF, Schreiber H, Fu Y-X. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14:1014–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christofides A, Strauss L, Yeo A, Cao C, Charest A, Boussiotis VA. The complex role of tumor-infiltrating macrophages. Nat Immunol. 2022;23:1148–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen S, Saeed AFUH, Liu Q, Jiang Q, Xu H, Xiao GG, et al. Macrophages in immunoregulation and therapeutics. Signal Transduct Target Ther. 2023;8:207.

Article 

留言 (0)

沒有登入
gif