Enhanced epithelial-mesenchymal transition signatures are linked with adverse tumor microenvironment, angiogenesis and worse survival in gastric cancer

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.

Article  PubMed  Google Scholar 

Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, et al. Epithelialization in wound healing: a comprehensive review. Adv Wound Care (N. Rochelle). 2014;3:445–64.

Article  Google Scholar 

Kim DH, Xing T, Yang Z, Dudek R, Lu Q, Chen YH. Epithelial mesenchymal transition in embryonic development, tissue repair and cancer: a comprehensive overview. J Clin Med. 2017;7:1.

Article  PubMed  PubMed Central  Google Scholar 

Barriere G, Fici P, Gallerani G, Fabbri F, Rigaud M. Epithelial mesenchymal transition: a double-edged sword. Clin Transl Med. 2015;4:14.

Article  PubMed  PubMed Central  Google Scholar 

Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2020;21:341–52.

Article  PubMed  PubMed Central  Google Scholar 

Etienne-Manneville S. Polarity proteins in migration and invasion. Oncogene. 2008;27:6970–80.

Article  CAS  PubMed  Google Scholar 

Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest. 2009;119:1429–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oshi M, Newman S, Tokumaru Y, Yan L, Matsuyama R, Endo I, et al. Intra-tumoral angiogenesis is associated with inflammation, immune reaction and metastatic recurrence in breast cancer. Int J Mol Sci. 2020;21:6708.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oshi M, Tokumaru Y, Angarita FA, Yan L, Matsuyama R, Endo I, Takabe K. Degree of early estrogen response predict survival after endocrine therapy in primary and metastatic ER-positive breast cancer. Cancers (Basel). 2020;12:3557.

Article  CAS  PubMed  Google Scholar 

Oshi M, Kim TH, Tokumaru Y, Yan L, Matsuyama R, Endo I, et al. Enhanced DNA repair pathway is associated with cell proliferation and worse survival in hepatocellular carcinoma (HCC). Cancers (Basel). 2021;13:323.

Article  CAS  PubMed  Google Scholar 

Oshi M, Sarkar J, Tokumaru Y, Yan L, Kosaka T, Akiyama H, et al. Higher intra-tumoral expression of pro-coagulation genes is a predictor of angiogenesis, epithelial mesenchymal transition and worse patient survival in gastric cancer. Am J Cancer Res. 2022;12:4001–14.

CAS  PubMed  PubMed Central  Google Scholar 

Huang L, Wu RL, Xu AM. Epithelial-mesenchymal transition in gastric cancer. Am J Transl Res. 2015;7:2141–58.

CAS  PubMed  PubMed Central  Google Scholar 

Oshi M, Satyananda V, Angarita FA, Kim TH, Tokumaru Y, Yan L, et al. Angiogenesis is associated with an attenuated tumor microenvironment, aggressive biology, and worse survival in gastric cancer patients. Am J Cancer Res. 2021;11:1659–71.

CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, et al. An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics. Cell. 2018;173:400–.e11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoon SJ, Park J, Shin Y, Choi Y, Park SW, Kang SG, et al. Deconvolution of diffuse gastric cancer and the suppression of CD34 on the BALB/c nude mice model. BMC Cancer. 2020;20:314.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinforma. 2013;14:7.

Article  Google Scholar 

Liberzon A, Birger C, Thorvaldsdóttir H, Ghandi M, Mesirov JP, Tamayo P. The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1:417–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oshi M, Newman S, Tokumaru Y, Yan L, Matsuyama R, Endo I, et al. High G2M pathway score pancreatic cancer is associated with worse survival, particularly after margin-positive (R1 or R2) resection. Cancers (Basel). 2020;12:2871.

Article  CAS  PubMed  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102:15545–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34:267–73.

Article  CAS  PubMed  Google Scholar 

Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18:220.

Article  PubMed  PubMed Central  Google Scholar 

Oshi M, Asaoka M, Tokumaru Y, Yan L, Matsuyama R, Ishikawa T, et al. CD8 T cell score as a prognostic biomarker for triple negative breast cancer. Int J Mol Sci. 2020;21:6968.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oshi M, Huyser MR, Le L, Tokumaru Y, Yan L, Matsuyama R, et al. Abundance of microvascular endothelial cells Is associated with response to chemotherapy and prognosis in colorectal cancer. Cancers (Basel). 2021;13:1477.

Article  CAS  PubMed  Google Scholar 

Oshi M, Newman S, Tokumaru Y, Yan L, Matsuyama R, Kalinski P, et al. Plasmacytoid dendritic cell (pDC) infiltration correlate with tumor infiltrating lymphocytes, cancer immunity, and better survival in triple negative breast cancer (TNBC) more strongly than conventional dendritic cell (cDC). Cancers (Basel). 2020;12:3342.

Article  CAS  PubMed  Google Scholar 

Oshi M, Asaoka M, Tokumaru Y, Angarita FA, Yan L, Matsuyama R, et al. Abundance of regulatory T cell (Treg) as a predictive biomarker for neoadjuvant chemotherapy in triple-negative breast cancer. Cancers (Basel). 2020;12:3038.

Article  CAS  PubMed  Google Scholar 

Wu R, Roy AM, Tokumaru Y, Gandhi S, Asaoka M, Oshi M, et al. NR2F1, a tumor dormancy marker, is expressed predominantly in cancer-associated fibroblasts and is associated with suppressed breast cancer cell proliferation. Cancers (Basel). 2022;14:2962.

Article  CAS  PubMed  Google Scholar 

Oshi M, Roy AM, Gandhi S, Tokumaru Y, Yan L, Yamada A, et al. The clinical relevance of unfolded protein response signaling in breast cancer. Am J Cancer Res. 2022;12:2627–40.

CAS  PubMed  PubMed Central  Google Scholar 

Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, et al. The immune landscape of cancer. Immunity. 2018;48:812–.e14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatzikirou H, Basanta D, Simon M, Schaller K, Deutsch A. Go or grow’: the key to the emergence of invasion in tumour progression? Math Med Biol. 2012;29:49–65.

Article  CAS  PubMed  Google Scholar 

Giese A, Loo MA, Tran N, Haskett D, Coons SW, Berens ME. Dichotomy of astrocytoma migration and proliferation. Int J Cancer. 1996;67:275–82.

Article  CAS  PubMed  Google Scholar 

Massagué J, Obenauf AC. Metastatic colonization by circulating tumour cells. Nature. 2016;529:298–306.

Article  PubMed  PubMed Central  Google Scholar 

Oshi M, Takahashi H, Tokumaru Y, Yan L, Rashid OM, Matsuyama R, et al. G2M cell cycle pathway score as a prognostic biomarker of metastasis in estrogen receptor (ER)-positive breast cancer. Int J Mol Sci. 2020;21:2921.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oshi M, Patel A, Le L, Tokumaru Y, Yan L, Matsuyama R, et al. G2M checkpoint pathway alone is associated with drug response and survival among cell proliferation-related pathways in pancreatic cancer. Am J Cancer Res. 2021;11:3070–84.

CAS  PubMed  PubMed Central  Google Scholar 

Böttinger EP, Bitzer M. TGF-beta signaling in renal disease. J Am Soc Nephrol. 2002;13:2600–10.

Article  PubMed  Google Scholar 

Matsuyama S, Iwadate M, Kondo M, Saitoh M, Hanyu A, Shimizu K, et al. SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. Cancer Res. 2003;63:7791–8.

CAS  PubMed  Google Scholar 

Fuxe J, Karlsson MC. TGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammation. Semin Cancer Biol. 2012;22:455–61.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif