IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3β by Upregulating GRPR in Hippocampal Neurons of Autistic Mice

Abbah J, Vacher CM, Goldstein EZ et al (2022) Oxidative stress-Induced damage to the developing Hippocampus is mediated by GSK3β. J Neurosci 42(24):4812–4827

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmed S, Abir AH, Sharmin O et al (2023) Modulation of PI3K/Akt/GSK3β signaling cascade through G protein-coupled receptor 55 (GPR55) activation: prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction. Life Sci 334:122195

Article  CAS  PubMed  Google Scholar 

Bagcioglu E, Solmaz V, Erbas O et al (2023) Modafinil improves autism-like behavior in rats by reducing neuroinflammation. J Neuroimmune Pharmacol 18(1–2):9–23

Article  PubMed  Google Scholar 

Battle DE (2013) Diagnostic and statistical manual of mental disorders (DSM). Codas 25(2):191–192

PubMed  Google Scholar 

Bilanges B, Posor Y, Vanhaesebroeck B (2019) PI3K isoforms in cell signalling and vesicle trafficking. Nat Rev Mol Cell Biol 20(9):515–534

Article  CAS  PubMed  Google Scholar 

Brown JA, Sherrod SD, Goodwin CR et al (2014) Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia. J Neuroinflammation 11:183

Article  PubMed  PubMed Central  Google Scholar 

Cao Q, Meng T, Man J et al (2019) aFGF promotes neurite growth by regulating GSK3β-CRMP2 signaling pathway in cortical neurons damaged by Amyloid-β. J Alzheimers Dis 72(1):97–109

Article  CAS  PubMed  Google Scholar 

Careaga M, Murai T, Bauman MD (2017) Maternal Immune activation and autism spectrum disorder: from rodents to nonhuman and human primates. Biol Psychiatry 81(5):391–401

Article  CAS  PubMed  Google Scholar 

Chen J, Alberts I, Li X (2014) Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders. Int J Dev Neurosci 35:35–41

Article  PubMed  Google Scholar 

Chen X, Garelick MG, Wang H, Lil V, Athos J, Storm DR (2005) PI3 kinase signaling is required for retrieval and extinction of contextual memory. Nat Neurosci 8(7):925–931

Article  CAS  PubMed  Google Scholar 

Cieślik M, Zawadzka A, Czapski GA, Wilkaniec A, Adamczyk A (2023) Developmental stage-dependent changes in mitochondrial function in the brain of offspring following prenatal maternal immune activation. Int J Mol Sci 24(8):7243

Article  PubMed  PubMed Central  Google Scholar 

Fang WQ, Ip JP, Li R et al (2011) Cdk5-mediated phosphorylation of Axin directs axon formation during cerebral cortex development. J Neurosci 31(38):13613–13624

Article  CAS  PubMed  PubMed Central  Google Scholar 

García-Juárez M, Camacho-Morales A (2022) Defining the role of anti- and pro-inflammatory outcomes of interleukin-6 in mental health. Neuroscience 492:32–46

Article  PubMed  Google Scholar 

Gazestani VH, Pramparo T, Nalabolu S et al (2019) A perturbed gene network containing PI3K-AKT, RAS-ERK and WNT-β-catenin pathways in leukocytes is linked to ASD genetics and symptom severity. Nat Neurosci 22(10):1624–1634

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gilbert J, Man HY (2017) Fundamental elements in Autism: from neurogenesis and neurite growth to synaptic plasticity. Front Cell Neurosci 11:359

Article  PubMed  PubMed Central  Google Scholar 

Guma E, Bordignon P, Devenyi GA et al (2021) Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: an integrated neuroimaging, behavioral, and transcriptional study. Biol Psychiatry 90(5):328–341

Article  CAS  PubMed  Google Scholar 

Hodges SL, Womble PD, Kwok EM et al (2021) Rapamycin, but not minocycline, significantly alters ultrasonic vocalization behavior in C57BL/6J pups in a flurothyl seizure model. Behav Brain Res 410:113317

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horváth G, Otrokocsi L, Beko K et al (2019) P2 × 7 receptors drive poly(I:C) Induced autism-like behavior in mice. J Neurosci 39(13):2542–2561

PubMed  PubMed Central  Google Scholar 

Horwood JM, Dufour F, Laroche S, Davis S (2006) Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci 23(12):3375–3384

Article  PubMed  Google Scholar 

Hu CC, Xu X, Xiong GL et al (2018) Alterations in plasma cytokine levels in chinese children with autism spectrum disorder. Autism Res 11(7):989–999

Article  PubMed  Google Scholar 

Jaworski T, Banach-Kasper E, Gralec K (2019) GSK-3β at the intersection of neuronal plasticity and neurodegeneration. Neural Plast 2019:4209475

Article  PubMed  PubMed Central  Google Scholar 

Jones KL, Croen LA, Yoshida CK et al (2017) Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation. Mol Psychiatry 22(2):273–279

Article  CAS  PubMed  Google Scholar 

Kritman M, Maroun M (2013) Inhibition of the PI3 kinase cascade in corticolimbic circuit: temporal and differential effects on contextual fear and extinction. Int J Neuropsychopharmacol 16(4):825–833

Article  CAS  PubMed  Google Scholar 

Le Belle JE, Sperry J, Ngo A et al (2014) Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells. Stem Cell Rep 3(5):725–734

Article  Google Scholar 

Lesh TA, Iosif AM, Tanase C et al (2023) Extracellular free water elevations are associated with brain volume and maternal cytokine response in a longitudinal nonhuman primate maternal immune activation model. Mol Psychiatry 28(10):4185–4194

Article  CAS  PubMed  Google Scholar 

Li H, Wang X, Hu C et al (2022) JUN and PDGFRA as crucial candidate genes for childhood autism spectrum disorder. Front Neuroinform 16:800079

Article  PubMed  PubMed Central  Google Scholar 

Li X, Chauhan A, Sheikh AM et al (2009) Elevated immune response in the brain of autistic patients. J Neuroimmunol 207(1–2):111–116

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Wang Y, Zeng Y et al (2023) Microglia-neuron interactions promote chronic itch via the NLRP3-IL-1β-GRPR axis. Allergy 78(6):1570–1584

Article  CAS  PubMed  Google Scholar 

Lombardo MV, Moon HM, Su J, Palmer TD, Courchesne E, Pramparo T (2018) Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder. Mol Psychiatry 23(4):1001–1013

Article  CAS  PubMed  Google Scholar 

Lugo JN, Smith GD, Arbuckle EP et al (2014) Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins. Front Mol Neurosci 7:27

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maenner MJ, Warren Z, Williams AR et al (2023) Prevalence and characteristics of autism spectrum disorder among children aged 8 years - Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2020. MMWR Surveill Summ 72(2):1–14

Article  PubMed  PubMed Central  Google Scholar 

Malkova NV, Yu CZ, Hsiao EY et al (2012) Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav Immun 26(4):607–616

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merali Z, Presti-Torres J, Mackay JC et al (2014) Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: similarities to autism spectrum disorders. Behav Brain Res 263:60–69

Article  CAS  PubMed  Google Scholar 

Nakao K, Singh M, Sapkota K et al (2020) GSK3β inhibition restores cortical gamma oscillation and cognitive behavior in a mouse model of NMDA receptor hypofunction relevant to schizophrenia. Neuropsychopharmacology 45(13):2207–2218

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pereira PJ, Machado GD, Danesi GM et al (2015) GRPR/PI3Kγ: partners in central transmission of itch. J Neurosci 35(49):16272–16281

Article  CAS  PubMed  PubMed Central  Google Scholar 

Presti-Torres J, Garcia VA, Dornelles A et al (2012) Rescue of social behavior impairment by clozapine and alterations in the expression of neuronal receptors in a rat model of neurodevelopmental impairment induced by GRPR blockade. J Neural Transm (Vienna) 119(3):319–327

Article  CAS  PubMed  Google Scholar 

Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F (2013) Genome engineering using the CRISPR-Cas9 system. Nat Protoc 8(11):2281–2308

Article  CAS

留言 (0)

沒有登入
gif