Perioperative Levels of IL8 and IL18, but not IL6, are Associated with Nucleus Basalis Magnocellularis Atrophy Three Months after Surgery

Adage T, Del Bene F, Fiorentini F, Doornbos RP, Zankl C, Bartley MR, Kungl AJ (2015) PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation. Cytokine 76(2):433–441. https://doi.org/10.1016/j.cyto.2015.08.006

Article  CAS  PubMed  Google Scholar 

Anazodo UC, Shoemaker JK, Suskin N, St Lawrence KS (2013) An investigation of changes in regional gray matter volume in cardiovascular disease patients, pre and post cardiovascular rehabilitation. Neuroimage Clin 3:388–395. https://doi.org/10.1016/j.nicl.2013.09.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avram M, Grothe MJ, Meinhold L, Leucht C, Leucht S, Borgwardt S, Brandl F, Sorg C (2021) Lower cholinergic basal forebrain volumes link with cognitive difficulties in schizophrenia. Neuropsychopharmacology 46(13):2320–2329. https://doi.org/10.1038/s41386-021-01070-x

Article  PubMed  PubMed Central  Google Scholar 

Ballweg T, White M, Parker M, Casey C, Bo A, Farahbakhsh Z, Kayser A, Blair A, Lindroth H, Pearce RA, Blennow K, Zetterberg H, Lennertz R, Sanders RD (2021) Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study. Br J Anaesth 126(2):458–466. https://doi.org/10.1016/j.bja.2020.08.061

Article  CAS  PubMed  Google Scholar 

Banks WA, Kastin AJ, Gutierrez EG (1994) Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci Lett 179(1–2):53–56. https://doi.org/10.1016/0304-3940(94)90933-4

Article  CAS  PubMed  Google Scholar 

Baune BT, Ponath G, Golledge J, Varga G, Arolt V, Rothermundt M, Berger K (2008) Association between IL-8 cytokine and cognitive performance in an elderly general population–the MEMO-Study. Neurobiol Aging 29(6):937–944. https://doi.org/10.1016/j.neurobiolaging.2006.12.003

Article  CAS  PubMed  Google Scholar 

Berlot R, Pirtosek Z, Brezovar S, Koritnik B, Teipel SJ, Grothe MJ, Ray NJ (2022) Cholinergic basal forebrain and hippocampal structure influence visuospatial memory in Parkinson’s disease. Brain Imaging Behav 16(1):118–129. https://doi.org/10.1007/s11682-021-00481-0

Article  PubMed  Google Scholar 

Bilusic M, Heery CR, Collins JM, Donahue RN, Palena C, Madan RA, Karzai F, Marte JL, Strauss J, Gatti-Mays ME, Schlom J, Gulley JL (2019) Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors. J Immunother Cancer 7(1):240. https://doi.org/10.1186/s40425-019-0706-x

Article  PubMed  PubMed Central  Google Scholar 

Bosancic Z, Spies CD, Müller A, Winterer G, Piper SK, Heinrich M (2022) Association of cholinesterase activities and POD in older adult abdominal surgical patients. BMC Anesthesiol 22(1):293. https://doi.org/10.1186/s12871-022-01826-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Butler T, Harvey P, Deshpande A, Tanzi E, Li Y, Tsui W, Silver C, Fischer E, Wang X, Chen J, Rusinek H, Pirraglia E, Osorio RS, Glodzik L, de Leon MJ (2018) Basal forebrain septal nuclei are enlarged in healthy subjects prior to the development of Alzheimer’s disease. Neurobiol Aging 65:201–205. https://doi.org/10.1016/j.neurobiolaging.2018.01.014

Article  PubMed  PubMed Central  Google Scholar 

Casey CP, Lindroth H, Mohanty R, Farahbakhsh Z, Ballweg T, Twadell S, Miller S, Krause B, Prabhakaran V, Blennow K, Zetterberg H, Sanders RD (2020) Postoperative delirium is associated with increased plasma neurofilament light. Brain 143(1):47–54. https://doi.org/10.1093/brain/awz354

Article  PubMed  Google Scholar 

Cavallari M, Dai W, Guttmann CR, Meier DS, Ngo LH, Hshieh TT, Callahan AE, Fong TG, Schmitt E, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Inouye SK, Alsop DC, Group SS (2016) Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI. Brain 139(Pt 4):1282–1294. https://doi.org/10.1093/brain/aww010

Article  Google Scholar 

Cavedo E, Grothe MJ, Colliot O, Lista S, Chupin M, Dormont D, Houot M, Lehericy S, Teipel S, Dubois B, Hampel H, Hippocampus Study G (2017) Reduced basal forebrain atrophy progression in a randomized Donepezil trial in prodromal Alzheimer’s disease. Sci Rep 7(1):11706. https://doi.org/10.1038/s41598-017-09780-3

Article  CAS  Google Scholar 

Conti B, Park LC, Calingasan NY, Kim Y, Kim H, Bae Y, Gibson GE, Joh TH (1999) Cultures of astrocytes and microglia express interleukin 18. Brain Res Mol Brain Res 67(1):46–52. https://doi.org/10.1016/s0169-328x(99)00034-0

Article  CAS  PubMed  Google Scholar 

Feinkohl I, Borchers F, Burkhardt S, Krampe H, Kraft A, Speidel S, Kant IMJ, van Montfort SJT, Aarts E, Kruppa J, Slooter A, Winterer G, Pischon T, Spies C (2020) Stability of neuropsychological test performance in older adults serving as normative controls for a study on postoperative cognitive dysfunction. BMC Res Notes 13(1):55. https://doi.org/10.1186/s13104-020-4919-3

Article  PubMed  PubMed Central  Google Scholar 

Field RH, Gossen A, Cunningham C (2012) Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. J Neurosci 32(18):6288–6294. https://doi.org/10.1523/JNEUROSCI.4673-11.2012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gabay C, Fautrel B, Rech J, Spertini F, Feist E, Kotter I, Hachulla E, Morel J, Schaeverbeke T, Hamidou MA, Martin T, Hellmich B, Lamprecht P, Schulze-Koops H, Courvoisier DS, Sleight A, Schiffrin EJ (2018) Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still’s disease. Ann Rheum Dis 77(6):840–847. https://doi.org/10.1136/annrheumdis-2017-212608

Article  CAS  PubMed  Google Scholar 

Grothe M, Heinsen H, Teipel S (2013) Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer’s disease. Neurobiol Aging 34(4):1210–1220. https://doi.org/10.1016/j.neurobiolaging.2012.10.018

Article  CAS  PubMed  Google Scholar 

Gu Y, Vorburger R, Scarmeas N, Luchsinger JA, Manly JJ, Schupf N, Mayeux R, Brickman AM (2017) Circulating inflammatory biomarkers in relation to brain structural measurements in a non-demented elderly population. Brain Behav Immun 65:150–160. https://doi.org/10.1016/j.bbi.2017.04.022

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Khachaturian ZS (2018) The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain 141(7):1917–1933. https://doi.org/10.1093/brain/awy132

Article  PubMed  PubMed Central  Google Scholar 

Heinrich M, Müller A, Lammers-Lietz F, Borchers F, Mörgeli R, Kruppa J, Zacharias N, Winterer G, Slooter AJC, Spies CD (2020) Radiological, Chemical and Pharmacological Cholinergic System Parameters and Neurocognitive Disorders in Older Pre-Surgical Adults. J Gerontol: Series A. https://doi.org/10.1093/gerona/glaa182

Article  Google Scholar 

Heinrich M, Sieg M, Kruppa J, Nurnberg P, Schreier PH, Heilmann-Heimbach S, Hoffmann P, Nothen MM, Janke J, Pischon T, Slooter AJC, Winterer G, Spies CD (2021) Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients. BMC Med Genomics 14(1):248. https://doi.org/10.1186/s12920-021-01071-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Houdek HM, Larson J, Watt JA, Rosenberger TA (2014) Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain. Inflamm Cell Signal 1(1). https://doi.org/10.14800/ics.47

Kant IMJ, de Bresser J, van Montfort SJT, Witkamp TD, Walraad B, Spies CD, Hendrikse J, van Dellen E, Slooter AJC, BioCog C (2023) Postoperative delirium is associated with grey matter brain volume loss. Brain Commun 5(1):fcad013. https://doi.org/10.1093/braincomms/fcad013

Kilimann I, Hausner L, Fellgiebel A, Filippi M, Wurdemann TJ, Heinsen H, Teipel SJ (2017) Parallel Atrophy of Cortex and Basal Forebrain Cholinergic System in Mild Cognitive Impairment. Cereb Cortex 27(3):1841–1848. https://doi.org/10.1093/cercor/bhw019

Article  PubMed  Google Scholar 

Kline RP, Pirraglia E, Cheng H, De Santi S, Li Y, Haile M, de Leon MJ, Bekker A, Neuroimaging AD, I. (2012) Surgery and brain atrophy in cognitively normal elderly subjects and subjects diagnosed with mild cognitive impairment. Anesthesiology 116(3):603–612. https://doi.org/10.1097/ALN.0b013e318246ec0b

Article  PubMed  Google Scholar 

Kline R, Wong E, Haile M, Didehvar S, Farber S, Sacks A, Pirraglia E, de Leon MJ, Bekker A (2016) Peri-Operative Inflammatory Cytokines in Plasma of the Elderly Correlate in Prospective Study with Postoperative Changes in Cognitive Test Scores. Int J Anesthesiol Res 4(8):313–321. https://doi.org/10.19070/2332-2780-1600065

Knaak C, Vorderwulbecke G, Spies C, Piper SK, Hadzidiakos D, Borchers F, Brockhaus WR, Radtke FM, Lachmann G (2019) C-reactive protein for risk prediction of post-operative delirium and post-operative neurocognitive disorder. Acta Anaesthesiol Scand 63(10):1282–1289. https://doi.org/10.1111/aas.13441

Article  CAS  PubMed  Google Scholar 

Lammers F, Borchers F, Feinkohl I, Hendrikse J, Kant IMJ, Kozma P, Pischon T, Slooter AJC, Spies C, van Montfort SJT, Zacharias N, Zaborszky L, Winterer G, BioCog, c. (2018) Basal forebrain cholinergic system volume is associated with general cognitive ability in the elderly. Neuropsychologia 119:145–156. https://doi.org/10.1016/j.neuropsychologia.2018.08.005

Article  PubMed  PubMed Central  Google Scholar 

Lammers F, Zacharias N, Borchers F, Morgeli R, Spies CD, Winterer G (2020) Functional Connectivity of the Supplementary Motor Network Is Associated with Fried’s Modified Frailty Score in Older Adults. J Gerontol A Biol Sci Med Sci 75(12):2239–2248. https://doi.org/10.1093/gerona/glz297

Article  PubMed  Google Scholar 

Lammers F, Mobascher A, Musso F, Shah NJ, Warbrick T, Zaborszky L, Winterer G (2016) Effects of Ncl. Basalis Meynert volume on the Trail-Making-Test are restricted to the left hemisphere. Brain Behav 6(1):e00421. https://doi.org/10.1002/brb3.421

Lammers-Lietz F, Akyuz L, Feinkohl I, Lachmann C, Pischon T, Volk HD, von Hafen C, Yurek F, Winterer G, Spies CD (2022a) Interleukin 8 in postoperative delirium - Preliminary findings from two studies. Brain Behav Immun Health 20:100419. https://doi.org/10.1016/j.bbih.2022.100419

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lammers-Lietz F, Zacharias N, Morgeli R, Spies CD, Winterer G (2022b) Functional connectivity of the supplementary and presupplementary motor areas in postoperative transition between stages of frailty. J Gerontol A Biol Sci Med Sci. https://doi.org/10.1093/gerona/glac012

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif