Chen P, Liu Y, Wen Y, Zhou C. Non-small cell lung cancer in China. Cancer Commun (Lond). 2022;42(10):937–70. https://doi.org/10.1002/cac2.12359.

Article  PubMed  Google Scholar 

Yang H, Gao Y, Fan X, Liu X, Peng L, Ci X. Oridonin sensitizes Cisplatin-Induced apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 cells. Front Oncol. 2019;9:769. https://doi.org/10.3389/fonc.2019.00769.

Article  PubMed  PubMed Central  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660.

Article  PubMed  Google Scholar 

Cao W, Chen HD, Yu YW, Li N, Chen WQ. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl). 2021;134(7):783–91. https://doi.org/10.1097/cm9.0000000000001474.

Article  PubMed  Google Scholar 

Wang M, Herbst RS, Boshoff C. Toward personalized treatment approaches for non-small-cell lung cancer. Nat Med. 2021;27(8):1345–56. https://doi.org/10.1038/s41591-021-01450-2.

Article  CAS  PubMed  Google Scholar 

Osmani L, Askin F, Gabrielson E, Li QK. Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): moving from targeted therapy to immunotherapy. Semin Cancer Biol. 2018;52(Pt 1):103–9. https://doi.org/10.1016/j.semcancer.2017.11.019.

Article  CAS  PubMed  Google Scholar 

Doroshow DB, Sanmamed MF, Hastings K, Politi K, Rimm DL, Chen L, et al. Immunotherapy in Non-small Cell Lung Cancer: facts and hopes. Clin Cancer Res. 2019;25(15):4592–602. https://doi.org/10.1158/1078-0432.Ccr-18-1538.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geisler AN, Phillips GS, Barrios DM, Wu J, Leung DYM, Moy AP, et al. Immune checkpoint inhibitor-related dermatologic adverse events. J Am Acad Dermatol. 2020;83(5):1255–68. https://doi.org/10.1016/j.jaad.2020.03.132.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Q, Tang L, Zhou Y, He W, Li W. Immune Checkpoint inhibitor-Associated Pneumonitis in Non-small Cell Lung Cancer: current understanding in characteristics, diagnosis, and management. Front Immunol. 2021;12:663986. https://doi.org/10.3389/fimmu.2021.663986.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang L, Wang J, Lin N, Zhou Y, He W, Liu J, et al. Immune Checkpoint inhibitor-Associated Colitis: from mechanism to management. Front Immunol. 2021;12:800879. https://doi.org/10.3389/fimmu.2021.800879.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S, Long S, Deng Z, Wu W. Positive role of Chinese Herbal Medicine in Cancer Immune Regulation. Am J Chin Med. 2020;48(7):1577–92. https://doi.org/10.1142/s0192415x20500780.

Article  CAS  PubMed  Google Scholar 

Li Z, Feiyue Z, Gaofeng L. Traditional Chinese medicine and lung cancer–from theory to practice. Biomed Pharmacother. 2021;137:111381. https://doi.org/10.1016/j.biopha.2021.111381.

Article  PubMed  Google Scholar 

Wei C, Yao X, Jiang Z, Wang Y, Zhang D, Chen X, et al. Cordycepin inhibits drug-resistance non-small cell Lung Cancer Progression by activating AMPK Signaling Pathway. Pharmacol Res. 2019;144:79–89. https://doi.org/10.1016/j.phrs.2019.03.011.

Article  CAS  PubMed  Google Scholar 

Zhang FY, Li RZ, Xu C, Fan XX, Li JX, Meng WY, et al. Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa. Phytomedicine. 2022;95:153786. https://doi.org/10.1016/j.phymed.2021.153786.

Article  CAS  PubMed  Google Scholar 

Tian Y, Zhai X, Yan W, Zhu H, Yu J. Clinical outcomes of immune checkpoint blockades and the underlying immune escape mechanisms in squamous and adenocarcinoma NSCLC. Cancer Med. 2021;10(1):3–14. https://doi.org/10.1002/cam4.3590.

Article  CAS  PubMed  Google Scholar 

Zhang Q, Xiao X, Li M, Yu M, Ping F. Bailing capsule (Cordyceps Sinensis) ameliorates renal triglyceride accumulation through the PPARα pathway in diabetic rats. Front Pharmacol. 2022;13:915592. https://doi.org/10.3389/fphar.2022.915592.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sheng X, Dong Y, Cheng D, Wang N, Guo Y. Efficacy and safety of bailing capsules in the treatment of type 2 diabetic nephropathy: a meta-analysis. Ann Palliat Med. 2020;9(6):3885–98. https://doi.org/10.21037/apm-20-1799.

Article  PubMed  Google Scholar 

Zhang L, Zhao Y, Jia J, Huang L, Chu W, Xu Q, et al. Evaluation of the curative effects of bailing capsules for treating chronic obstructive pulmonary disease: a protocol for systematic review and meta-analysis. Med (Baltim). 2021;100(25):e25672. https://doi.org/10.1097/md.0000000000025672.

Article  CAS  Google Scholar 

Xu H, Li S. [Pharmacological effects of bailing capsule and its application in lung disease research]. Zhongguo Zhong Yao Za Zhi. 2010;35(20):2777–81.

PubMed  Google Scholar 

Leung EL, Li RZ, Fan XX, Wang LY, Wang Y, Jiang Z, et al. Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy. Nat Commun. 2023;14(1):5115. https://doi.org/10.1038/s41467-023-40631-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Li RZ, Wang WJ, Pan HD, Xie C, Yau LF, et al. CERS4 predicts positive anti-PD-1 response and promotes immunomodulation through Rhob-mediated suppression of CD8(+)Tim3(+) exhausted T cells in non-small cell lung cancer. Pharmacol Res. 2023;194:106850. https://doi.org/10.1016/j.phrs.2023.106850.

Article  CAS  PubMed  Google Scholar 

Li K, Cheng H, Shen W, Leung EL, Le S, Yu L, et al. Compound Taxus chinensis Capsule Combined with Chemotherapy for Non-small-cell Lung Cancer: a PRISMA-Compliant systematic review and Meta-analysis of Randomized controlled trials. Evid Based Complement Alternat Med. 2021;2021:9535061. https://doi.org/10.1155/2021/9535061.

Article  PubMed  PubMed Central  Google Scholar 

Yang H, Guo Q, Wu J, Zhong L, Sun L, Liu W, et al. Deciphering the effects and mechanisms of Yi-Fei-San-Jie-pill on Non-small Cell Lung Cancer with Integrating Network Target Analysis and experimental validation. Front Pharmacol. 2022;13:851554. https://doi.org/10.3389/fphar.2022.851554.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Q, Huang Y, Li Y, Zhang L, Tang H, Zhang J, et al. Glycyrrhizic acid mitigates tripterygium-glycoside-tablet-induced acute liver injury via PKM2 regulated oxidative stress. Metabolites. 2022. https://doi.org/10.3390/metabo12111128.

Article  PubMed  PubMed Central  Google Scholar 

Zhao B, Hui X, Zeng H, Yin Y, Huang J, Tang Q, et al. Sophoridine inhibits the Tumour Growth of Non-small Lung Cancer by Inducing macrophages M1 Polarisation via MAPK-Mediated inflammatory pathway. Front Oncol. 2021;11:634851. https://doi.org/10.3389/fonc.2021.634851.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Lei W, Chen X, Wang S, Qian W. Oxidative stress response induced by chemotherapy in leukemia treatment. Mol Clin Oncol. 2018;8(3):391–9. https://doi.org/10.3892/mco.2018.1549.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Xu D, Chen B, Huang D, Li Z, Sui Y, et al. Delicaflavone represses Lung Cancer Growth by activating Antitumor Immune response through N6-Methyladenosine transferases and oxidative stress. Oxid Med Cell Longev. 2022;2022:8619275. https://doi.org/10.1155/2022/8619275.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ankney JA, Muneer A, Chen X. Relative and absolute quantitation in Mass Spectrometry-based proteomics. Annu Rev Anal Chem (Palo Alto Calif). 2018;11(1):49–77. https://doi.org/10.1146/annurev-anchem-061516-045357.

Article  CAS  PubMed  Google Scholar 

Patel AJ, Richter A, Drayson MT, Middleton GW. The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer. Cancer Immunol Immunother. 2020;69(3):325–42. https://doi.org/10.1007/s00262-019-02461-2.

Article  PubMed  PubMed Central  Google Scholar 

Khiem D, Cyster JG, Schwarz JJ, Black BL. A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A. 2008;105(44):17067–72. https://doi.org/10.1073/pnas.0804868105.

Article  PubMed  PubMed Central  Google Scholar 

McLaurin JD, Weiner OD. Multiple sources of signal amplification within the B-cell Ras/MAPK pathway. Mol Biol Cell. 2019;30(13):1610–20. https://doi.org/10.1091/mbc.E18-09-0560.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pradhan R, Singhvi G, Dubey SK, Gupta G, Dua K. MAPK pathway: a potential target for the treatment of non-small-cell lung carcinoma. Future Med Chem. 2019;11(8):793–5. https://doi.org/10.4155/fmc-2018-0468.

Article  CAS  PubMed