Bazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17/TNF inflammatory pathway associated with SASP

Pontzer H, Yamada Y, Sagayama H, Ainslie PN, Andersen LF, Anderson LJ, et al. Daily energy expenditure through the human life course. Science. 2021;373:808–12. https://doi.org/10.1126/science.abe5017.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zoico E, Rubele S, De Caro A, Nori N, Mazzali G, Fantin F, et al. Brown and beige adipose tissue and aging. Front Endocrinol. 2019;10:368. https://doi.org/10.3389/fendo.2019.00368.

Article  Google Scholar 

Mancuso P, Bouchard B. The impact of aging on adipose function and adipokine synthesis. Front Endocrinol. 2019;10:137. https://doi.org/10.3389/fendo.2019.00137.

Article  Google Scholar 

Chait A, den Hartigh LJ. Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med. 2020;7:22. https://doi.org/10.3389/fcvm.2020.00022.

Article  CAS  PubMed  PubMed Central  Google Scholar 

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186:243–78. https://doi.org/10.1016/j.cell.2022.11.001.

Article  CAS  PubMed  Google Scholar 

Manini TM. Energy expenditure and aging. Ageing Res Rev. 2010;9:1–11. https://doi.org/10.1016/j.arr.2009.08.002.

Article  CAS  PubMed  Google Scholar 

Drożdż K, Nabrdalik K, Hajzler W, Kwiendacz H, Gumprecht J, Lip GYH. Metabolic-associated fatty liver disease (mafld), diabetes, and cardiovascular disease: associations with fructose metabolism and gut microbiota. Nutrients. 2021. https://doi.org/10.3390/nu14010103.

Article  PubMed  PubMed Central  Google Scholar 

Deprince A, Haas JT, Staels B. Dysregulated lipid metabolism links nafld to cardiovascular disease. Mol Metab. 2020;42: 101092. https://doi.org/10.1016/j.molmet.2020.101092.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pirillo A, Casula M, Olmastroni E, Norata GD, Catapano AL. Global epidemiology of dyslipidaemias. Nat Rev Cardiol. 2021;18:689–700. https://doi.org/10.1038/s41569-021-00541-4.

Article  CAS  PubMed  Google Scholar 

Guo J, Huang X, Dou L, Yan M, Shen T, Tang W, et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct Target Ther. 2022;7:391. https://doi.org/10.1038/s41392-022-01251-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct Target Ther. 2023;8:239. https://doi.org/10.1038/s41392-023-01502-8.

Article  PubMed  PubMed Central  Google Scholar 

Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–7.

Article  CAS  PubMed  Google Scholar 

Zhu X, Chen Z, Shen W, Huang G, Sedivy JM, Wang H, et al. Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention. Signal Transduct Target Ther. 2021;6:245. https://doi.org/10.1038/s41392-021-00646-9.

Article  PubMed  PubMed Central  Google Scholar 

Kumari R, Jat P. Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front Cell Dev Biol. 2021;9: 645593. https://doi.org/10.3389/fcell.2021.645593.

Article  PubMed  PubMed Central  Google Scholar 

Wiley CD, Campisi J. The metabolic roots of senescence: mechanisms and opportunities for intervention. Nat Metab. 2021;3:1290–301. https://doi.org/10.1038/s42255-021-00483-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalinkovich A, Livshits G. Sarcopenic obesity or obese sarcopenia: a cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev. 2017;35:200–21. https://doi.org/10.1016/j.arr.2016.09.008.

Article  CAS  PubMed  Google Scholar 

Stahl EC, Delgado ER, Alencastro F, Lopresti ST, Wilkinson PD, Roy N, et al. Inflammation and ectopic fat deposition in the aging murine liver is influenced by ccr2. Am J Pathol. 2020;190:372–87. https://doi.org/10.1016/j.ajpath.2019.10.016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, et al. Cellular senescence drives age-dependent hepatic steatosis. Nat Commun. 2017;8:15691. https://doi.org/10.1038/ncomms15691.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chung KW. Advances in understanding of the role of lipid metabolism in aging. Cells. 2021. https://doi.org/10.3390/cells10040880.

Article  PubMed  PubMed Central  Google Scholar 

Hildebrandt X, Ibrahim M, Peltzer N. Cell death and inflammation during obesity: “know my methods, wat(son).” Cell Death Differ. 2023;30:279–92. https://doi.org/10.1038/s41418-022-01062-4.

Article  CAS  PubMed  Google Scholar 

Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese. Biomed Pharmacother. 2021;137:111315. https://doi.org/10.1016/j.biopha.2021.111315.

Article  CAS  PubMed  Google Scholar 

Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14:576–90. https://doi.org/10.1038/s41574-018-0059-4.

Article  CAS  PubMed  Google Scholar 

Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018;15:505–22. https://doi.org/10.1038/s41569-018-0064-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaib S, Tchkonia T, Kirkland JL. Cellular senescence and senolytics: the path to the clinic. Nat Med. 2022;28:1556–68. https://doi.org/10.1038/s41591-022-01923-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, et al. Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell. 2019;18: e12950. https://doi.org/10.1111/acel.12950.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, et al. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018;24:1246–56. https://doi.org/10.1038/s41591-018-0092-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mbara KC, Devnarain N, Owira PMO. Potential role of polyphenolic flavonoids as senotherapeutic agents in degenerative diseases and geroprotection. Pharmaceut Med. 2022;36:331–52. https://doi.org/10.1007/s40290-022-00444-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bjørklund G, Shanaida M, Lysiuk R, Butnariu M, Peana M, Sarac I, et al. Natural compounds and products from an anti-aging perspective. Molecules. 2022. https://doi.org/10.3390/molecules27207084.

Article  PubMed  PubMed Central  Google Scholar 

Mora I, Arola L, Caimari A, Escoté X, Puiggròs F. Structured long-chain omega-3 fatty acids for improvement of cognitive function during aging. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23073472.

Article  PubMed  PubMed Central  Google Scholar 

Lam YY, Peterson CM, Ravussin E. Resveratrol vs. Calorie restriction: data from rodents to humans. Exp Gerontol. 2013;48:1018–24. https://doi.org/10.1016/j.exger.2013.04.005.

Article  CAS  PubMed  Google Scholar 

Bereswill S, Muñoz M, Fischer A, Plickert R, Haag L, Otto B, et al. Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS ONE. 2010;5: e15099. https://doi.org/10.1371/journal.pone.0015099.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bisht K, Wagner K, Bulmer AC. Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and dna-protective dietary compounds. Toxicology. 2010;278:88–100. https://doi.org/10.1016/j.tox.2009.11.008.

Article  CAS  PubMed  Google Scholar 

Huang D, Hu H, Chang L, Liu S, Liang J, Song Y, et al. Chinese medicine bazi bushen capsule improves lipid metabolism in ovariectomized female apoe-/- mice. Ann Palliat Med. 2020;9:1073–83. https://doi.org/10.21037/apm-20-906.

Article 

留言 (0)

沒有登入
gif